L-Hexoses are key components of many biologically relevant natural products and pharmaceuticals.As rare sugars,L-hexoses are not readily obtained from natural sources.Access to L-hexose building blocks from commercial...L-Hexoses are key components of many biologically relevant natural products and pharmaceuticals.As rare sugars,L-hexoses are not readily obtained from natural sources.Access to L-hexose building blocks from commercially available and inexpensive D-sugars is highly desirable from the viewpoints of organic synthesis and drug discovery.As demonstrated by the convenient preparation of L-glucosyl,L-galactosyl,and L-mannosyl fluorides from readily availableβ-D-C-glucosyl,β-D-C-mannosyl,andβ-D-C-galactosyl derivatives,we describe a novel and efficient approach to the demanding L-glycosyl fluorides.展开更多
基金support from the Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology(Qingdao)(No.2022QNLM030003-2)the National Natural Science Foundation of China(Nos.21977088 and 21672194)the National Natural Science Foundation of China-Shandong Joint Fund(No.U1906213)。
文摘L-Hexoses are key components of many biologically relevant natural products and pharmaceuticals.As rare sugars,L-hexoses are not readily obtained from natural sources.Access to L-hexose building blocks from commercially available and inexpensive D-sugars is highly desirable from the viewpoints of organic synthesis and drug discovery.As demonstrated by the convenient preparation of L-glucosyl,L-galactosyl,and L-mannosyl fluorides from readily availableβ-D-C-glucosyl,β-D-C-mannosyl,andβ-D-C-galactosyl derivatives,we describe a novel and efficient approach to the demanding L-glycosyl fluorides.
