Objective Evidence on potential cardiovascular benefits of personal-level intervention among the elderly exposed to high levels of particulate matter(PM)remains limited.We aimed to assess improvements in surrogate mar...Objective Evidence on potential cardiovascular benefits of personal-level intervention among the elderly exposed to high levels of particulate matter(PM)remains limited.We aimed to assess improvements in surrogate markers of cardiovascular injury in vulnerable populations at risks by using indoor air filtration units.Methods We conducted a randomized crossover trial for 2 separate 2-week air filtration interventions in 20 households of patients with stable chronic obstructive pulmonary disease and their partners in the winter of 2013,with concurrent measurements of indoor PM.The changes in biomarkers indicative of cardiac injury,atherosclerosis progression and systemic inflammation following intervention were evaluated using linear mixed-effect models.Results In the analysis,average levels of indoor PM with aerodynamic diameters<2.5µm(PM2.5)decreased significantly by 59.2%(from 59.6 to 24.3µg/m3,P<0.001)during the active air filtration.The reduction was accompanied by improvements in levels of high-sensitivity cardiac troponin I by−84.6%(95%confidence interval[CI]:−90.7 to−78.6),growth differentiation factor-15 by−48.1%(95%CI:−31.2 to−25.6),osteoprotegerin by−65.4%(95%CI:−56.5 to−18.7),interleukin-4 by−46.6%(95%CI:−62.3 to−31.0)and myeloperoxidase by−60.3%(95%CI:−83.7 to−3.0),respectively.Conclusion Indoor air filtration intervention may provide potential cardiovascular benefits in vulnerable populations at risks.展开更多
The concentration of metallic elements is closely associated with overall health.However,the discharge of untreated industrial wastewater can lead to metal-containing pollutants entering the human body through the foo...The concentration of metallic elements is closely associated with overall health.However,the discharge of untreated industrial wastewater can lead to metal-containing pollutants entering the human body through the food chain,disrupting the organism’s homeostasis and posing a risk to human health.Co-valent organic framework materials(COFs)have emerged as a novel porous material for detecting or adsorbing metal ions due to their unique pore structure,topological structure and flexible design.This paper summarizes the role,toxicity,and sources of metal ions related to human health,as well as the design,synthesis and performance of COFs fluorescent materials for detecting these elements.The inter-action mechanism of different fluorescent COFs and metal ions are discussed.Additionally,the remaining challenges and prospects of COFs fluorescence sensors are provided.We believe this review will be useful in directing the development of fluorescent COFs towards metal ions.展开更多
基金This work was supported by Beijing Natural Science Foundation(7222246)Royal Dutch Philips Electronics Ltd.(Grant NL18-2100478471).
文摘Objective Evidence on potential cardiovascular benefits of personal-level intervention among the elderly exposed to high levels of particulate matter(PM)remains limited.We aimed to assess improvements in surrogate markers of cardiovascular injury in vulnerable populations at risks by using indoor air filtration units.Methods We conducted a randomized crossover trial for 2 separate 2-week air filtration interventions in 20 households of patients with stable chronic obstructive pulmonary disease and their partners in the winter of 2013,with concurrent measurements of indoor PM.The changes in biomarkers indicative of cardiac injury,atherosclerosis progression and systemic inflammation following intervention were evaluated using linear mixed-effect models.Results In the analysis,average levels of indoor PM with aerodynamic diameters<2.5µm(PM2.5)decreased significantly by 59.2%(from 59.6 to 24.3µg/m3,P<0.001)during the active air filtration.The reduction was accompanied by improvements in levels of high-sensitivity cardiac troponin I by−84.6%(95%confidence interval[CI]:−90.7 to−78.6),growth differentiation factor-15 by−48.1%(95%CI:−31.2 to−25.6),osteoprotegerin by−65.4%(95%CI:−56.5 to−18.7),interleukin-4 by−46.6%(95%CI:−62.3 to−31.0)and myeloperoxidase by−60.3%(95%CI:−83.7 to−3.0),respectively.Conclusion Indoor air filtration intervention may provide potential cardiovascular benefits in vulnerable populations at risks.
基金supported by a grant from National Natural Science Foundation of China(Nos.82204176,12175103)the Nuclear Materials of China Atomic Energy Authority(ICNM-2023-ZH-22)+2 种基金the Natural Science Foundation of Guizhou Province(No.ZK[2022]551)the Program for Graduate Innovation Research of Hunan Province(No.CX20230993)the Innovation and Entrepreneurship Training Program for College Students of Hunan Province(No.S202210555315).
文摘The concentration of metallic elements is closely associated with overall health.However,the discharge of untreated industrial wastewater can lead to metal-containing pollutants entering the human body through the food chain,disrupting the organism’s homeostasis and posing a risk to human health.Co-valent organic framework materials(COFs)have emerged as a novel porous material for detecting or adsorbing metal ions due to their unique pore structure,topological structure and flexible design.This paper summarizes the role,toxicity,and sources of metal ions related to human health,as well as the design,synthesis and performance of COFs fluorescent materials for detecting these elements.The inter-action mechanism of different fluorescent COFs and metal ions are discussed.Additionally,the remaining challenges and prospects of COFs fluorescence sensors are provided.We believe this review will be useful in directing the development of fluorescent COFs towards metal ions.
