Cancer progression is marked by the infiltration of immunosuppressive cells,such as tumor-associated macrophages(TAMs),regulatory T lymphocytes(Tregs),and myeloid-derived suppressor cells(MDSCs).These cells play a key...Cancer progression is marked by the infiltration of immunosuppressive cells,such as tumor-associated macrophages(TAMs),regulatory T lymphocytes(Tregs),and myeloid-derived suppressor cells(MDSCs).These cells play a key role in abrogating the cytotoxic T lymphocyte-mediated(CTL)immune response,allowing tumor growth to proceed unabated.Furthermore,targeting these immunosuppressive cells through the use of peptides and peptide-based nanomedicine has shown promising results.Here we review the origins and functions of immunosuppressive cells in cancer progression,peptide-based systems used in their targeting,and explore future avenues of research regarding cancer immunotherapy.The success of these studies demonstrates the importance of the tumor immune microenvironment in the propagation of cancer and the potential of peptide-based nanomaterials as immunomodulatory agents.展开更多
基金The authors would like to acknowledge the financial support from the National Heart,Lung,and Blood Institute(NHLBI,R00HL124279)NIH New Innovator Award(DP2DK121328)L.K.Whittier Foundation,Ming Hsieh Institute for Research on Engineering-Medicine for Cancer,the Women in Science and Engineering Gabilan Assistant Professorship,and the University of Southern California startup funds awarded to EJC.
文摘Cancer progression is marked by the infiltration of immunosuppressive cells,such as tumor-associated macrophages(TAMs),regulatory T lymphocytes(Tregs),and myeloid-derived suppressor cells(MDSCs).These cells play a key role in abrogating the cytotoxic T lymphocyte-mediated(CTL)immune response,allowing tumor growth to proceed unabated.Furthermore,targeting these immunosuppressive cells through the use of peptides and peptide-based nanomedicine has shown promising results.Here we review the origins and functions of immunosuppressive cells in cancer progression,peptide-based systems used in their targeting,and explore future avenues of research regarding cancer immunotherapy.The success of these studies demonstrates the importance of the tumor immune microenvironment in the propagation of cancer and the potential of peptide-based nanomaterials as immunomodulatory agents.
