This paper focuses on the study and control of a non-linear mathematical epidemic model ( SSvihVELI ) based on a system of ordinary differential equation modeling the spread of tuberculosis infectious with HIV/AIDS co...This paper focuses on the study and control of a non-linear mathematical epidemic model ( SSvihVELI ) based on a system of ordinary differential equation modeling the spread of tuberculosis infectious with HIV/AIDS coinfection. Existence of both disease free equilibrium and endemic equilibrium is discussed. Reproduction number R0 is determined. Using Lyapunov-Lasalle methods, we analyze the stability of epidemic system around the equilibriums (disease free and endemic equilibrium). The global asymptotic stability of the disease free equilibrium whenever Rvac is proved, where R0 is the reproduction number. We prove also that when R0 is less than one, tuberculosis can be eradicated. Numerical simulations are conducted to approve analytic results. To achieve control of the disease, seeking to reduce the infectious group by the minimum vaccine coverage, a control problem is formulated. The Pontryagin’s maximum principle is used to characterize the optimal control. The optimality system is derived and solved numerically using the Runge Kutta fourth procedure.展开更多
This paper proposes a system representation for unifying control design and numerical calculation in nonlinear optimal control problems with inequality constraints in terms of the symplectic structure. The symplectic ...This paper proposes a system representation for unifying control design and numerical calculation in nonlinear optimal control problems with inequality constraints in terms of the symplectic structure. The symplectic structure is derived from Hamiltonian systems that are equivalent to Hamilton-Jacobi equations. In the representation, the constraints can be described as an input-state transformation of the system. Therefore, it can be seamlessly applied to the stable manifold method that is a precise numerical solver of the Hamilton-Jacobi equations. In conventional methods, e.g., the penalty method or the barrier method, it is difficult to systematically assign the weights of penalty functions that are used for realizing the constraints. In the proposed method, we can separate the adjustment of weights with respect to objective functions from that of penalty functions. Furthermore, the proposed method can extend the region of computable solutions in a state space. The validity of the method is shown by a numerical example of the optimal control of a vehicle model with steering limitations.展开更多
文摘This paper focuses on the study and control of a non-linear mathematical epidemic model ( SSvihVELI ) based on a system of ordinary differential equation modeling the spread of tuberculosis infectious with HIV/AIDS coinfection. Existence of both disease free equilibrium and endemic equilibrium is discussed. Reproduction number R0 is determined. Using Lyapunov-Lasalle methods, we analyze the stability of epidemic system around the equilibriums (disease free and endemic equilibrium). The global asymptotic stability of the disease free equilibrium whenever Rvac is proved, where R0 is the reproduction number. We prove also that when R0 is less than one, tuberculosis can be eradicated. Numerical simulations are conducted to approve analytic results. To achieve control of the disease, seeking to reduce the infectious group by the minimum vaccine coverage, a control problem is formulated. The Pontryagin’s maximum principle is used to characterize the optimal control. The optimality system is derived and solved numerically using the Runge Kutta fourth procedure.
文摘This paper proposes a system representation for unifying control design and numerical calculation in nonlinear optimal control problems with inequality constraints in terms of the symplectic structure. The symplectic structure is derived from Hamiltonian systems that are equivalent to Hamilton-Jacobi equations. In the representation, the constraints can be described as an input-state transformation of the system. Therefore, it can be seamlessly applied to the stable manifold method that is a precise numerical solver of the Hamilton-Jacobi equations. In conventional methods, e.g., the penalty method or the barrier method, it is difficult to systematically assign the weights of penalty functions that are used for realizing the constraints. In the proposed method, we can separate the adjustment of weights with respect to objective functions from that of penalty functions. Furthermore, the proposed method can extend the region of computable solutions in a state space. The validity of the method is shown by a numerical example of the optimal control of a vehicle model with steering limitations.
