Unlocking axon regeneration in the injured central nervous system:In adult mammals,central nervous system(CNS)neurons fail to regenerate a?ter a lesion,whether it is traumatic–after spinal cord injury for example–or...Unlocking axon regeneration in the injured central nervous system:In adult mammals,central nervous system(CNS)neurons fail to regenerate a?ter a lesion,whether it is traumatic–after spinal cord injury for example–or in the case of neurodegenerative diseases.This causes axons to degenerate and neurons to die.展开更多
One of the hallmarks of the mature neurons from the central nervous system(CNS)is their inability to grow their axons after an insult.In turn,whenever a neuronal circuit is damaged,either by a neurodegenerative diseas...One of the hallmarks of the mature neurons from the central nervous system(CNS)is their inability to grow their axons after an insult.In turn,whenever a neuronal circuit is damaged,either by a neurodegenerative disease or a traumatic injury,the motor and/or cognitive fu nctions associated with it are lost permanently.Therefore,understanding the molecular and cellular barriers to CNS repair is a major challenge not only for Neurosciences but also for public health.展开更多
基金the French National Research Agency under the"Investissements d'avenir"program(ANR-17-EURE-0003)(to SB and HN)ERC-St17-759089-DRIVE and NRJ Foundation to HN and ANR ANR-18-CE16-0007 to SB+1 种基金a postdoctoral fellowship from Fondation pour la Recherche Médicale(FRM)SPF201909009106a PhD extension fellowship from Fondation pour la recherche médicale(FRM)-Programme Fin de Thèse FDT202204014716。
文摘Unlocking axon regeneration in the injured central nervous system:In adult mammals,central nervous system(CNS)neurons fail to regenerate a?ter a lesion,whether it is traumatic–after spinal cord injury for example–or in the case of neurodegenerative diseases.This causes axons to degenerate and neurons to die.
基金supported by ERCSt17-759089-DRIVE and NRJ Foundation(to HN)。
文摘One of the hallmarks of the mature neurons from the central nervous system(CNS)is their inability to grow their axons after an insult.In turn,whenever a neuronal circuit is damaged,either by a neurodegenerative disease or a traumatic injury,the motor and/or cognitive fu nctions associated with it are lost permanently.Therefore,understanding the molecular and cellular barriers to CNS repair is a major challenge not only for Neurosciences but also for public health.
