Review of the Therapeutic Advance of Acne Treatment

Acne vulgaris is among the most frequent chronic skin disorders in adolescents, characterized by inflammation of the pilosebaceous unit. The psychological distress due to the disfiguring is the main problem that affects the quality of life for patients suffering from acne. Drugs for the treatment of acne are one of the main contents of drug research on common skin diseases. Acne treatment has remained relatively unaltered over the last years. Still, in conjunction with the increase of bacterial resistance to antibiotics throughout the world, there is a global trend away from antibiotic monotherapy treatment. This review discussed the currently used treatment options and evaluated the issues and evidence supporting their usage for patients with acne, including drug therapy with topical, oral, hormonal therapy, and so on. Drug therapy is the most common method in the clinic. Due to the multifactorial etiology of acne vulgaris, most drugs cannot meet the treatment requirements. Therefore, the screening and development of excellent drugs are one of the key targets for treating acne in the future.

阿拉伯茶对口腔和皮肤的影响

目的 探讨阿拉伯茶对口腔和皮肤的影响。方法 采用微信问卷星对高校学生进行问卷调查。选取正在吸食阿拉伯茶的当地也门高校学生(A组),停止吸食的也门籍在华留学生(B组)作为研究对象,采集其社会学特征、口腔及皮肤临床特征,其中B组调查了既往吸食阿拉伯茶(B0)及停止吸食(2~4)年后(B1)两个阶段的临床特征。结果 591名被调查者中,男性占85.45%,女性占14.55%;56.51%年龄在(25~34)岁;学士、硕士分别占48.56%、40.65%;75.63%的学生吸食时间> 3年;75.12%吸食阿拉伯茶是为了提高学习的积极性,保持充沛精力。吸食阿拉伯茶(A组)可出现舌变黄(38.44%)、口腔溃疡32.50%、口腔咀嚼疼痛28.13%、牙龈出血26.87%、口腔异味23.75%、舌裂纹21.56%、嘴角裂缝9.37%等口腔症状,停止吸食后仍有上述症状但较吸食时减轻(P <0.05):其中口腔异味占15.87%,牙龈出血占13.65%、舌变黄占11.44%、口腔溃疡占11.07%、嘴角裂缝占9.60%、咀嚼疼痛占8.49%、舌裂纹占7.38%;还可导致皮肤老化(34.06%)、多汗症(25.00%)、皮肤干燥(19.37%)、脓肿(14.37%)、皮肤瘙痒(13.44%)、身体臭味(12.81%)、口周疱疹(10.00%)、紫癜(6.56%),停止吸食后皮肤老化占(14.02%)、多汗症占(8.86%)、皮肤干燥占(8.12%)、脓肿占(5.54%)、皮肤瘙痒占(5.54%)、身体臭味占(5.17%)、口腔疱疹占(4.80%)、紫癜占(2.21%),均显著减轻(P <0.05)。结论长期吸食阿拉伯茶会对口腔和皮肤健康造成许多负面影响。