Background Cardiovascular disease(CVD)is a common cause of death in China.There have been many evidences that inflammatory factors and acute phase reactants play an important role in the pathogenesis of coronary heart...Background Cardiovascular disease(CVD)is a common cause of death in China.There have been many evidences that inflammatory factors and acute phase reactants play an important role in the pathogenesis of coronary heart disease and acute coronary syndromes,and their related factors may become indicators for predicting and diagnosing early cardiovascular disease.Recent evidence has shown that human cartilage glycoprotein 39(YKL-40)is related to metabolic disorders caused by inflammatory diseases and heart diseases.YKL-40 is a new type of inflammation marker.Studies have shown that YKL-40 can further aggravate vascular damage and can be used as a biomarker for assessing the severity of cardiovascular disease and judging the prognosis.This article reviewed the biological characteristics of YKL-40 and its relationship with cardiovascular diseases.[S Chin J Cardiol 2021;22(1):57-64]展开更多
Background Exosomes are bilayer lipid membranous vesicles with a diameter of 40-100 nm.They play an important role in signal transduction among cellular substances.Exosomes miR-206 and miR-122-5 have been found to pla...Background Exosomes are bilayer lipid membranous vesicles with a diameter of 40-100 nm.They play an important role in signal transduction among cellular substances.Exosomes miR-206 and miR-122-5 have been found to play a regulatory role in cardiovascular diseases such as chronic heart failure,and therefore have gradually become the focus of various studies.The review has introduced the biological characteristics of the exosomal microRNAs,the association between exosomes miR-122-5 p,miR-206 and chronic heart failure,and briefly described the therapeutic prospects of these two exosomal miRNAs in the treatment of chronic heart failure.It may provide some new directions for the diagnosis and treatment of heart failure.展开更多
Background Epicardial adipose tissue(EAT)is a unique visceral adipose tissue that is located between the myocardium and the visceral layer of the pericardium.Physiologically,EAT can produce heat and protect the heart....Background Epicardial adipose tissue(EAT)is a unique visceral adipose tissue that is located between the myocardium and the visceral layer of the pericardium.Physiologically,EAT can produce heat and protect the heart.Under pathological conditions,EAT is involved in the development of diastolic heart failure(DHF)by secreting a variety of pro-inflammatory cytokines.More and more studies have shown that EAT plays an important role in the inflammatory mechanism and myocardial remodeling of DHF.Exercise,weight loss and drug therapy can significantly reduce the thickness/volume of EAT and its functional disorder.In recent years,research on EAT and DHF has made new progress.This article reviewed the mechanism and treatment of EAT in the development of DHF.展开更多
Background Noncompaction of ventricular myocardium （NVM） is a rare type of primary cardiomyopathy. The disease is caused by the disorder in the densification of the myocardium in the early stage of the embryo proces...Background Noncompaction of ventricular myocardium （NVM） is a rare type of primary cardiomyopathy. The disease is caused by the disorder in the densification of the myocardium in the early stage of the embryo process. The morphological characteristics are projecting trabeculation in the ventricle and the deep trabecular space interlinked with ventricular chamber. In recent years, many studies have found that the left ventricular growth associated genetic mutation is closely related to the occurrence of NVM. The most clinical manifestations such as heart failure, thromboembolism and arrhythmia are specific. Echocardiography is the most commonly used tech- nique for the diagnosis of NVM. Cardiac computed tomography （CT） scan, cardiac magnetic resonance imaging and left ventricular angiography are other important techniques for its diagnosis. The NVM patients have a long course of disease, poor prognosis and a high rate of misdiagnosis. This article reviews the research progress in the aspects of epidemiological characteristics, genetic characteristics, clinical manifestations, pathophysiology, diagnosis, treatment and so on, in order to provide the basis for the diagnosis and treatment of NVM.展开更多
Background Myocardial fibrosis is one process of the various heart diseases, which leads to common pathological changes when it develops to a certain stage. It is the main cause of ventricular remodeling which eventua...Background Myocardial fibrosis is one process of the various heart diseases, which leads to common pathological changes when it develops to a certain stage. It is the main cause of ventricular remodeling which eventually leads to different degrees of cardiac dysfunction, malignant arrhythmias and sudden cardiac death. Many studies have shown that various cytokines play a very important role in the development of myocardial fibrosis. This paper reviews the latest researches on the role of cytokines in myocardial fibrosis.展开更多
基金supported by Science and Technology Key Research Project in Jining(No.2018SMNS006)Teaching Case Library Project of 2018 Professional Degree Graduate Student in Shandong Province(No.SDYAL18100)
文摘Background Cardiovascular disease(CVD)is a common cause of death in China.There have been many evidences that inflammatory factors and acute phase reactants play an important role in the pathogenesis of coronary heart disease and acute coronary syndromes,and their related factors may become indicators for predicting and diagnosing early cardiovascular disease.Recent evidence has shown that human cartilage glycoprotein 39(YKL-40)is related to metabolic disorders caused by inflammatory diseases and heart diseases.YKL-40 is a new type of inflammation marker.Studies have shown that YKL-40 can further aggravate vascular damage and can be used as a biomarker for assessing the severity of cardiovascular disease and judging the prognosis.This article reviewed the biological characteristics of YKL-40 and its relationship with cardiovascular diseases.[S Chin J Cardiol 2021;22(1):57-64]
基金supported by the Jining City Science and Technology Key Research and Development Program(No. 2018SMNS006)the 2018 Shandong Province professional degree graduate case teaching project(No.SDYAL18100)
文摘Background Exosomes are bilayer lipid membranous vesicles with a diameter of 40-100 nm.They play an important role in signal transduction among cellular substances.Exosomes miR-206 and miR-122-5 have been found to play a regulatory role in cardiovascular diseases such as chronic heart failure,and therefore have gradually become the focus of various studies.The review has introduced the biological characteristics of the exosomal microRNAs,the association between exosomes miR-122-5 p,miR-206 and chronic heart failure,and briefly described the therapeutic prospects of these two exosomal miRNAs in the treatment of chronic heart failure.It may provide some new directions for the diagnosis and treatment of heart failure.
基金supported by the Jining City Science and Technology Key Research and Development Program(No.2018SMNS006)the 2018 Shandong Province professional degree graduate case teaching project(No.SDYAL18100)。
文摘Background Epicardial adipose tissue(EAT)is a unique visceral adipose tissue that is located between the myocardium and the visceral layer of the pericardium.Physiologically,EAT can produce heat and protect the heart.Under pathological conditions,EAT is involved in the development of diastolic heart failure(DHF)by secreting a variety of pro-inflammatory cytokines.More and more studies have shown that EAT plays an important role in the inflammatory mechanism and myocardial remodeling of DHF.Exercise,weight loss and drug therapy can significantly reduce the thickness/volume of EAT and its functional disorder.In recent years,research on EAT and DHF has made new progress.This article reviewed the mechanism and treatment of EAT in the development of DHF.
文摘Background Noncompaction of ventricular myocardium （NVM） is a rare type of primary cardiomyopathy. The disease is caused by the disorder in the densification of the myocardium in the early stage of the embryo process. The morphological characteristics are projecting trabeculation in the ventricle and the deep trabecular space interlinked with ventricular chamber. In recent years, many studies have found that the left ventricular growth associated genetic mutation is closely related to the occurrence of NVM. The most clinical manifestations such as heart failure, thromboembolism and arrhythmia are specific. Echocardiography is the most commonly used tech- nique for the diagnosis of NVM. Cardiac computed tomography （CT） scan, cardiac magnetic resonance imaging and left ventricular angiography are other important techniques for its diagnosis. The NVM patients have a long course of disease, poor prognosis and a high rate of misdiagnosis. This article reviews the research progress in the aspects of epidemiological characteristics, genetic characteristics, clinical manifestations, pathophysiology, diagnosis, treatment and so on, in order to provide the basis for the diagnosis and treatment of NVM.
文摘Background Myocardial fibrosis is one process of the various heart diseases, which leads to common pathological changes when it develops to a certain stage. It is the main cause of ventricular remodeling which eventually leads to different degrees of cardiac dysfunction, malignant arrhythmias and sudden cardiac death. Many studies have shown that various cytokines play a very important role in the development of myocardial fibrosis. This paper reviews the latest researches on the role of cytokines in myocardial fibrosis.
