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竹燕窝提取物的抑菌活性研究
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作者 冯鹏 俞骏晨 +5 位作者 王易鑫 贾玮 苏洋 汪瀚宇 廖菲 农向 《饲料研究》 CAS 北大核心 2024年第1期80-85,共6页
试验以竹燕窝(海绵胶煤炱菌)为材料开发新型饲料添加剂。采用正交试验确定竹燕窝提取物的最佳提取工艺条件。采用牛津杯法探讨竹燕窝乙醇提取物对3种革兰氏阳性菌[粪肠球菌(Enterococcus faecalis)、金黄色葡萄球菌(Staphylococcus aure... 试验以竹燕窝(海绵胶煤炱菌)为材料开发新型饲料添加剂。采用正交试验确定竹燕窝提取物的最佳提取工艺条件。采用牛津杯法探讨竹燕窝乙醇提取物对3种革兰氏阳性菌[粪肠球菌(Enterococcus faecalis)、金黄色葡萄球菌(Staphylococcus aureus)、表皮葡萄球菌(Staphylococcus epidermidis)]和3种革兰氏阴性菌[鼠伤寒沙门氏菌(Salmonella typhimurium)、鸡沙门氏菌(Salmonella pullorum)、大肠杆菌(Escherichia coli)]的抑菌效果。结果表明,竹燕窝抑菌提取物的最优提取工艺为乙醇浓度85%、液料比5 mL/g、提取时间180 min、提取温度50℃。竹燕窝乙醇提取物对革兰氏阳性菌的抑菌效果优于革兰氏阴性菌。研究表明,试验明确了竹燕窝在抑菌方面的潜在应用价值,可为抑菌产品的开发提供参考。 展开更多
关键词 竹燕窝 革兰氏阳性菌 革兰氏阴性菌 抑菌活性
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四川丛生竹林繁育大蚯蚓的实践与产业发展对策 被引量:1
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作者 廖鸿 陈会霖 +6 位作者 赵小宝 农向 龙文聪 汪瀚宇 肖析蒙 付春 杨瑶君 《竹子学报》 2023年第3期50-54,共5页
【目的】为探索丛生竹林繁育大蚯蚓(Pheretima aspergillum)的可行性,分析林下蚯蚓产业发展对策。【方法】慈竹(Bambusa emeiensis)林投放大蚯蚓种苗和增施保水竹纤维菌剂,以本地小蚯蚓(Amynthas benignus)为对照,采用大区对比、重复试... 【目的】为探索丛生竹林繁育大蚯蚓(Pheretima aspergillum)的可行性,分析林下蚯蚓产业发展对策。【方法】慈竹(Bambusa emeiensis)林投放大蚯蚓种苗和增施保水竹纤维菌剂,以本地小蚯蚓(Amynthas benignus)为对照,采用大区对比、重复试验的方法。【结果】四川丛生竹林大蚯蚓240 d的理论产量达2686 kg·hm^(-2),产值可达53000元·hm^(-2)。竹林发展蚯蚓产业具有阴凉、少病虫、变竹枝竹叶为地龙药材、绿色生态等四大优点,需要解决水分供应和竹枝竹叶的快速降解两大难题,该研究探索了竹林林下经济发展的新途径。【结论】四川丛生竹林发展林下大蚯蚓具有产量高、经济效益好等优点,建议科学规划竹林蚯蚓产业,组织专门的人才团队开展科技攻关,深入研究林下蚯蚓生长发育规律、药用价值的变化以及对竹林土壤理化性质、土壤养分、微生物多样性、凋落物分解和林分生长的作用机理,为竹林下蚯蚓产业的健康发展和乡村振兴提供技术支撑。 展开更多
关键词 丛生竹 蚯蚓 繁育实践 产业对策
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Realization of T_(e0)>10 keV long pulse operation over 100 s on EAST 被引量:2
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作者 龚先祖 徐立清 +31 位作者 钱金平 黄娟 丁锐 A M GAROFALO Annika EKEDAHL 曾龙 李二众 张斌 林士耀 沈飙 王茂 徐旵东 张新军 李妙辉 左桂忠 臧庆 刘海庆 吕波 王亮 孙有文 徐国盛 胡建生 姚达毛 武玉 胡立群 肖炳甲 项农 陆坤 宋云涛 万宝年 李建刚 the EAST Team 《Plasma Science and Technology》 SCIE EI CAS CSCD 2023年第2期6-10,共5页
In 2021,EAST realized a steady-state long pulse with a duration over 100 s and a core electron temperature over 10 keV.This is an integrated operation that resolves several key issues,including active control of wall ... In 2021,EAST realized a steady-state long pulse with a duration over 100 s and a core electron temperature over 10 keV.This is an integrated operation that resolves several key issues,including active control of wall conditioning,long-lasting fully noninductive current and divertor heat/particle flux.The fully noninductive current is driven by pure radio frequency(RF)waves with a lower hybrid current drive power of 2.5 MW and electron cyclotron resonance heating of 1.4 MW.This is an excellent experimental platform on the timescale of hundreds of seconds for studying multiscale instabilities,electron-dominant transport and particle recycling(plasma-wall interactions)under weak collisionality. 展开更多
关键词 EAST tokamak high T_(e) integrated operation scenario
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Effect of kinetic ions on the toroidal double-tearing modes
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作者 张睿博 叶磊 +2 位作者 Yang Chen 项农 杨小庆 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第2期366-371,共6页
We investigate the effects of kinetic ions on double-tearing modes(DTMs) using the gyrokinetic particle-in-cell simulation code GEM with a gyrokinetic ion/fluid electron hybrid model. It is found that the ion kinetic ... We investigate the effects of kinetic ions on double-tearing modes(DTMs) using the gyrokinetic particle-in-cell simulation code GEM with a gyrokinetic ion/fluid electron hybrid model. It is found that the ion kinetic effects can decrease the growth rate of the DTMs. This effect is more significant for stronger coupling of DTMs with smaller distance between the rational surfaces. Kinetic ions can also enhance the coupling effect between the two rational surfaces. Energy transfer analyses between particles and wave fields show that the stabilizing effect of kinetic ions comes mainly from the perpendicular magnetic drift of ions in the coupling region and around the outer rational surface. 展开更多
关键词 double-tearing modes kinetic ions coupling effect
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对分课堂教学模式探索及在“植物生理学”教学中的应用 被引量:1
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作者 周勇 唐梅 +2 位作者 毛加宁 农向 杨雨濛 《教育教学论坛》 2020年第28期296-297,共2页
"对分课堂"(PAD课堂)是一种基于传统课堂和讨论课堂的交互式教学模式,该课题组以植物生理学课程教学为例,通过对"对分课堂"的教学操作模式、影响因素、教学效果评价和师生交互模式等方面进行探索和实践,在促进教师... "对分课堂"(PAD课堂)是一种基于传统课堂和讨论课堂的交互式教学模式,该课题组以植物生理学课程教学为例,通过对"对分课堂"的教学操作模式、影响因素、教学效果评价和师生交互模式等方面进行探索和实践,在促进教师教学效能感提升、促进学生主动参与课堂学习和研究、促进师生之间的沟通和交流等方面取得了良好的效果。 展开更多
关键词 对分课堂 教学模式 植物生理学
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敏感性皮肤与光敏性皮肤病的鉴别 被引量:3
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作者 农祥 孙思昊 何黎 《皮肤科学通报》 2020年第6期581-584,M0004,共5页
敏感性皮肤特指皮肤在生理或病理条件下发生的一种高反应状态,主要发生于面部,临床表现为受到物理、化学、精神等因素刺激时皮肤易出现灼热、刺痛、瘙痒及紧绷感等主观症状,伴或不伴红斑、鳞屑、毛细血管扩张等客观体征。光敏性皮肤病... 敏感性皮肤特指皮肤在生理或病理条件下发生的一种高反应状态,主要发生于面部,临床表现为受到物理、化学、精神等因素刺激时皮肤易出现灼热、刺痛、瘙痒及紧绷感等主观症状,伴或不伴红斑、鳞屑、毛细血管扩张等客观体征。光敏性皮肤病是以慢性光化性皮炎为主的与紫外线照射有关的病谱性疾病,两类疾病同时具有主要发生在面颈部、皮肤敏感的特点,又有不同的发病机制和临床特征。为此,本文就敏感性皮肤及光敏性皮肤病的定义、病因及发病机制、临床表现及治疗进行综述。 展开更多
关键词 敏感性皮肤 光敏性皮肤病 鉴别
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鲜红斑痣的治疗及进展 被引量:7
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作者 李丹晨 农祥 +1 位作者 方天雯 赵婷婷 《皮肤病与性病》 2020年第2期180-183,共4页
鲜红斑痣是一种先天性毛细血管畸形,在新生儿中发病率约为0.3%,一般无自行消退倾向,未经治疗或治疗不充分可随着年龄增大而进展,面积变大、颜色变深,颜色由粉红变为紫红,甚至增厚出现结节、化脓性肉芽肿,引起自发性出血或创伤后出血等... 鲜红斑痣是一种先天性毛细血管畸形,在新生儿中发病率约为0.3%,一般无自行消退倾向,未经治疗或治疗不充分可随着年龄增大而进展,面积变大、颜色变深,颜色由粉红变为紫红,甚至增厚出现结节、化脓性肉芽肿,引起自发性出血或创伤后出血等不良预后。传统方法因副作用大、疗效欠佳,大部分已淘汰,目前激光及光动力疗法发展迅速,成为鲜红斑痣的主流治疗方法,新的治疗思路也不断涌现。文章对PWS常用治疗方法及进展进行综述。 展开更多
关键词 鲜红斑痣 脉冲染料激光 光动力疗法 雷帕霉素 射频
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Realization of minute-long steady-state H-mode discharges on EAST 被引量:1
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作者 Xianzu GONG Baonian WAN +26 位作者 Jiangang LI Jinping QIAN Erzhong LI Fukun LIU Yanping ZHAO Mao WANG Handong XU A M GAROFALO Annika EKEDAH Siye. DINGJuan HUANG Ling ZHANG Qing ZANG Haiqing LIU Long ZENG Shiyao LIN Biao SHEN Bin ZHANG Linming SHAO Bingjia XIAO Jiansheng HU Chundong HU Liqun HU Liang WANG Youwen SUN GuoshengXU Yunfeng LIANG nong xiang 《Plasma Science and Technology》 SCIE EI CAS CSCD 2017年第3期1-3,共3页
In the 2016 EAST experimental campaign,a steady-state long-pulse H-mode discharge with an ITER-like tungsten divertor lasting longer than one minute has been obtained using only RF heating and current drive,through an... In the 2016 EAST experimental campaign,a steady-state long-pulse H-mode discharge with an ITER-like tungsten divertor lasting longer than one minute has been obtained using only RF heating and current drive,through an integrated control of the wall conditioning,plasma configuration,divertor heat flux,particle exhaust,impurity management,and effective coupling of multiple RF heating and current drive sources at high injected power.The plasma current(Ip - 0.45 MA) was fully-noninductively driven(Vloop 〈 0.0 V) by a combination of-2.5 MW LHW,-0.4 MW ECH and -0.8 MW ICRF.This result demonstrates the progress of physics and technology studies on EAST,and will benefit the physics basis for steady state operation of ITER and CFETR. 展开更多
关键词 long pulse steady state RF heating H-MODE
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Numerical and Experimental Evaluation of Shine-Through Loss and Beam Heating Due to Neutral Beam Injection on EAST 被引量:1
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作者 Jin-Fang Wang Ying-Ying Li +13 位作者 Bin Wu Yu-Qing Chen Jun Li Yong-Jian Xu Long-Xi Chen Bao-Long Hao Deng Zhou Juan Huang Si-Ye Ding Zhen Yang Ya-Wei Hou Xiao-Juan Liu nong xiang Institute of Plasma Physi 《Chinese Physics Letters》 SCIE CAS CSCD 2021年第5期46-50,共5页
This research applies experimental measurements and NUBEAM,ONETWO and TRANSP modules to investigate the shine-through(ST)loss ratio and beam heating percentage of neutral beam injection on EAST.Measurements and simula... This research applies experimental measurements and NUBEAM,ONETWO and TRANSP modules to investigate the shine-through(ST)loss ratio and beam heating percentage of neutral beam injection on EAST.Measurements and simulations confirm that the ST loss ratio increases linearly with beam energy,and decreases exponentially with plasma density.Moreover,using the multi-step fitting method,we present analytical quantitative expressions of ST loss ratio and beam heating percentage,which are valuable for the high parameter long-pulse experiments of EAST. 展开更多
关键词 Numerical and Experimental Evaluation of Shine-Through Loss and Beam Heating Due to Neutral Beam Injection on EAST
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乐山嘉州绿心公园巨桉感染焦枯病的调查
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作者 刘欣兰 农向 +2 位作者 黄兰英 闫玉婷 李惠敏 《乐山师范学院学报》 2018年第8期23-28,共6页
桉树焦枯病(Eucalyptus dieback)是一种由真菌引起的威胁桉树健康的重要病害,影响植株生长,可带来严重的经济损失。文章针对乐山市绿心公园巨桉焦枯病感染情况进行普查,走访巨桉林35处,叶部病害危害程度为轻度的有17处,占48.57%;中度17... 桉树焦枯病(Eucalyptus dieback)是一种由真菌引起的威胁桉树健康的重要病害,影响植株生长,可带来严重的经济损失。文章针对乐山市绿心公园巨桉焦枯病感染情况进行普查,走访巨桉林35处,叶部病害危害程度为轻度的有17处,占48.57%;中度17处,占48.57%;重度1处,占2.86%。枝梢病害危害程度为轻度的有30处,占85.71%;中度5处,占14.29%。树干为轻度危害的有34处,占97.14%;中度1处,占2.86%。调查表明乐山市绿心公园巨桉焦枯病感染较为严重的是绿心路小环线。 展开更多
关键词 绿心公园 焦枯病 巨桉
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Landau damping of electrons with bouncing motion in a radio-frequency plasma
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作者 Jun Tao nong xiang +1 位作者 Yemin Hu Yueheng Huang 《Chinese Physics B》 SCIE EI CAS CSCD 2021年第12期484-494,共11页
One-dimensional particle simulations have been conducted to study the interaction between a radio-frequency electrostatic wave and electrons with bouncing motion.It is shown that bounce resonance heating can occur at ... One-dimensional particle simulations have been conducted to study the interaction between a radio-frequency electrostatic wave and electrons with bouncing motion.It is shown that bounce resonance heating can occur at the first few harmonics of the bounce frequency(nω_(b),n=1,2,3,...).In the parameter regimes in which bounce resonance overlaps with Landau resonance,the higher harmonic bounce resonance may accelerate electrons at the velocity much lower than the wave phase velocity to Landau resonance region,enhancing Landau damping of the wave.Meanwhile,Landau resonance can increase the number of electrons in the lower harmonic bounce resonance region.Thus electrons can be efficiently heated.The result might be applicable for collisionless electron heating in low-temperature plasma discharges. 展开更多
关键词 first few harmonics bounce resonance Landau resonance resonance overlaps
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Effects of fast ions produced by ICRF heating on the pressure at EAST
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作者 Zhen ZHENG nong xiang +1 位作者 Cheng YANG Yingfeng XU 《Plasma Science and Technology》 SCIE EI CAS CSCD 2020年第2期38-46,共9页
Ion cyclotron resonance heating(ICRH),which can produce fast ions,is an important auxiliary heating method at EAST.To analyze the effect of ICRH-induced fast ions on the plasma pressure at EAST,simulations are perform... Ion cyclotron resonance heating(ICRH),which can produce fast ions,is an important auxiliary heating method at EAST.To analyze the effect of ICRH-induced fast ions on the plasma pressure at EAST,simulations are performed using TRANSP and TORIC codes.It is found that the ICRF-induced fast ion pressure cannot be negligible when the ICRF power is sufficiently high.The magnitude of the total ion pressure can be raised up to 60%of the total pressure as the input power rises above 3 MW.The pressure profile is also significantly modified when the resonant layer is changed.It is shown that by changing the wave frequency and antenna position,the total ion pressure profile can be broadened,which might provide an option for profile control at EAST. 展开更多
关键词 ICRH EQUILIBRIUM fast ion pressure minority heating
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Relativistic effect on synergy of electron cyclotron and lower hybrid waves on EAST
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作者 Longhao MA nong xiang +2 位作者 Yueheng HUANG Yemin HU Xuemei ZHAI 《Plasma Science and Technology》 SCIE EI CAS CSCD 2021年第12期32-41,共10页
In recent experiments on EAST,the electron temperature at the center can be raised to 9.7 ke V by injecting electron cyclotron(EC)and lower hybrid(LH)waves simultaneously.With such strong core electron heating,the rel... In recent experiments on EAST,the electron temperature at the center can be raised to 9.7 ke V by injecting electron cyclotron(EC)and lower hybrid(LH)waves simultaneously.With such strong core electron heating,the relativistic effect could play an important role in the interactions between the plasma and waves.In order to explore the relativistic effect on synergy between the EC and LH waves on EAST,ray-tracing/Fokker-Planck simulations are conducted to investigate electron heating for a typical discharge with a center electron temperature of 9.7 ke V.It is found that the relativistic effect can cause the EC wave to deposit its power deeper in the plasma core,where the synergy between the EC and LH waves occurs and enhances the absorption of the LH waves.As a result,a high center electron temperature can be achieved. 展开更多
关键词 electron cyclotron waves lower hybrid waves synergy effect relativistic effect
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Kinetic equilibrium reconstruction for the NBI-and ICRH-heated H-mode plasma on EAST tokamak
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作者 Zhen ZHENG nong xiang +8 位作者 Jiale CHEN Siye DING Hongfei DU Guoqiang LI Yifeng WANG Haiqing LIU Yingying LI Bo LYU Qing ZANG 《Plasma Science and Technology》 SCIE EI CAS CSCD 2018年第6期30-38,共9页
The equilibrium reconstruction is important to study the tokamak plasma physical processes.To analyze the contribution of fast ions to the equilibrium,the kinetic equilibria at two time-slices in a typical H-mode disc... The equilibrium reconstruction is important to study the tokamak plasma physical processes.To analyze the contribution of fast ions to the equilibrium,the kinetic equilibria at two time-slices in a typical H-mode discharge with different auxiliary heatings are reconstructed by using magnetic diagnostics,kinetic diagnostics and TRANSP code.It is found that the fast-ion pressure might be up to one-third of the plasma pressure and the contribution is mainly in the core plasma due to the neutral beam injection power is primarily deposited in the core region.The fast-ion current contributes mainly in the core region while contributes little to the pedestal current.A steep pressure gradient in the pedestal is observed which gives rise to a strong edge current.It is proved that the fast ion effects cannot be ignored and should be considered in the future study of EAST. 展开更多
关键词 kinetic equilibrium reconstruction NBI ICRH pressure gradient edge current fast ions
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Estimation of tungsten production from the upper divertor in EAST during edge localized modes
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作者 Jing Ou nong xiang +3 位作者 Zong-Zheng Men Ling Zhang Ji-Chan Xu Wei Gao 《Chinese Physics B》 SCIE EI CAS CSCD 2019年第12期223-230,共8页
During edge localized modes(ELMs), the sheath evolution in front of the Experimental Advanced Superconducting Tokamak(EAST) upper divertor is studied to estimate the sputtered tungsten(W) atoms from the divertor targe... During edge localized modes(ELMs), the sheath evolution in front of the Experimental Advanced Superconducting Tokamak(EAST) upper divertor is studied to estimate the sputtered tungsten(W) atoms from the divertor target. A large potential drop across the sheath is formed during ELMs by compared with inter-ELMs, and the maximum of sheath potential drop can exceed one thousand of e V in current EAST operation. Due to the enhancement of the sheath potential drop during ELMs, the W physical sputtering yield from the deuterium(D) ions and the impurity ions on the upper divertor target is found to be significant. It is established that the sputtered W yield during ELMs is at least higher by an order of magnitude than inter-ELMs, and D ions and carbon(C) ions are the main ions governing the W production for the current H-mode with ELMs discharges. With increase in the pedestal electron temperature, the maximum of the D and C ion impact energy during ELMs shows a nearly linear increase, and the D ions have sufficient impact energy to cause the strong W physical sputtering. As a consequence, the D ions may dominate the sputtered W flux from the divertor target when the C concentration is controlled less than one percent for the higher heating power H-mode with ELM discharges in near future. 展开更多
关键词 SHEATH edge localized modes impact energy
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Parametric decay instabilities of lower hybrid waves on CFETR
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作者 Taotao Zhou nong xiang +2 位作者 Chunyun Gan Guozhang Jia Jiale Chen 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第9期386-396,共11页
The lower hybrid current drive is a potential candidate for sustaining plasma current in tokamak steady-state oper-ations,which could be used in China Fusion Engineering Test Reactor(CFETR)with input power up to a few... The lower hybrid current drive is a potential candidate for sustaining plasma current in tokamak steady-state oper-ations,which could be used in China Fusion Engineering Test Reactor(CFETR)with input power up to a few tens of megawatts.Such high input power could trigger the well-known parametric instabilities(PIs)at the plasma edge affect-ing the propagation and absorption of the lower hybrid pump waves.By analytically solving the nonlinear dispersion relation describing PIs,an explicit expression of the PI growth rate is obtained and analyzed in detail.It is found that pressure is the key parameter determining the PI characteristics.Ion sound quasi-mode is the dominant decay channel in the low-pressure regime,while the ion cyclotron quasi-mode(ICQM),as well as its harmonics,becomes dominant in the intermediate regime.In the high-pressure regime,only one mixed channel is found,which is related to Landau damping by free-streaming ions.Analytical expressions of growth rates of these decay channels are also obtained to show the parameter dependence at different pressure limits.The above analytical results are used to estimate the PIs on a typical profile of CFETR,and verified by corresponding numerical calculations.ICQM is found to be the strongest decay channel with a considerable growth rate for CFETR. 展开更多
关键词 lower hybrid parametric instability CFETR
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Numerical study on the loss of fast ions produced by minority ion cyclotron resonance heating in EAST
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作者 Dingzong ZHANG Youjun HU +4 位作者 nong xiang Cheng YANG Wei SHEN Yanqing HUANG Hongbo LIU 《Plasma Science and Technology》 SCIE EI CAS CSCD 2021年第11期1-8,共8页
The classical prompt loss of fast ions produced by minority ion cyclotron resonance heating(ICRH)is studied by a guiding center orbit following code in the Experimental Advanced Superconducting Tokamak(EAST).It is fou... The classical prompt loss of fast ions produced by minority ion cyclotron resonance heating(ICRH)is studied by a guiding center orbit following code in the Experimental Advanced Superconducting Tokamak(EAST).It is found that the loss of fast ions produced by ICRH mainly appears in both ends of the resonance layer,while the loss of fast ions in the middle resonance layer is very small.The dominant fast loss comes from trapped ions,rather than from passing ions.Controlling the location of resonance layer at the plasma core may be more beneficial to the EAST tokamak ICRH.In addition,the loss distribution of fast ions is studied.The results show that the fast ions are mainly lost near the midplane in the poloidal direction,but almost uniformly in the toroidal direction.Moreover,we investigate the dependence of fast ion loss on the ICRH power.The simulation results show that the loss fraction of fast ions in both ends of the resonance region increases with the ion cyclotron range of frequencies(ICRF)power,but barely affects the loss of fast ions in the middle region. 展开更多
关键词 ion cyclotron resonance heating the loss of fast ions EAST
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利妥昔单抗联合糖皮质激素治疗天疱疮临床疗效和安全性评价 被引量:3
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作者 李晔 农祥 +3 位作者 黄玲 王敏 俞奕彤 何黎 《中国皮肤性病学杂志》 CAS CSCD 北大核心 2023年第1期52-57,共6页
目的评价利妥昔单抗(RTX)联合糖皮质激素(CS)治疗天疱疮的近期疗效和安全性。方法开展前瞻性研究,纳入2020年10月-2021年11月在昆明医科大学第一附属医院及大理大学附属医院就诊的37例天疱疮患者,试验组(n=18)采用利妥昔单抗联合糖皮质... 目的评价利妥昔单抗(RTX)联合糖皮质激素(CS)治疗天疱疮的近期疗效和安全性。方法开展前瞻性研究,纳入2020年10月-2021年11月在昆明医科大学第一附属医院及大理大学附属医院就诊的37例天疱疮患者,试验组(n=18)采用利妥昔单抗联合糖皮质激素治疗,对照组(n=19)予以单独糖皮质激素或糖皮质激素联合环孢素(CsA)治疗。观察和比较治疗24周后的完全缓解率、人均累积糖皮质激素剂量、不良反应、抗体值变化等。结果24周后试验组完全缓解率(50.00%)高于对照组(10.53%)(P<0.05),人均累积糖皮质激素剂量低(P<0.05),糖皮质激素相关不良反应少。感染为本次研究中最常见不良反应,利妥昔单抗联合糖皮质激素组共发生5例次(27.78%),对照组发生9例次(47.37%);试验组2例利妥昔单抗治疗后皮损加重,合并多形红斑、松弛性大疱、表皮松解坏死,考虑并发药疹。基线时两组抗Dsg1、Dsg3抗体值差异无统计学意义(P>0.05),24周后试验组的抗Dsg1、Dsg3抗体值较对照组低(P<0.05)。结论利妥昔单抗联合糖皮质激素治疗天疱疮能够提高治疗24周后的完全缓解率,减少患者糖皮质激素用药量,同时减少大剂量糖皮质激素和免疫抑制剂相关不良反应,但应谨防感染和相关药疹的发生。 展开更多
关键词 天疱疮 利妥昔单抗 糖皮质激素 疗效 安全性
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食物特异性IgG抗体与慢性自发性荨麻疹表型的相关性研究 被引量:1
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作者 佟馨 吴剑 +13 位作者 张立明 高兴华 连石 张海萍 朱威 郭在培 黎静宜 李萌萌 何黎 农祥 普雄明 于世荣 陈洪铎 肖汀 《中华皮肤科杂志》 CAS CSCD 北大核心 2023年第2期130-135,共6页
目的探讨食物特异性IgG(sIgG)与慢性自发性荨麻疹(CSU)表型的相关性。方法连续收集2014年4月至2015年3月于中国医科大学附属第一医院等5家三级甲等医院皮肤科门诊就诊的活动期CSU、皮肤划痕症(SD)、急性荨麻疹(AU)患者和健康对照血清,... 目的探讨食物特异性IgG(sIgG)与慢性自发性荨麻疹(CSU)表型的相关性。方法连续收集2014年4月至2015年3月于中国医科大学附属第一医院等5家三级甲等医院皮肤科门诊就诊的活动期CSU、皮肤划痕症(SD)、急性荨麻疹(AU)患者和健康对照血清,酶联免疫吸附法检测90种食物抗原sIgG抗体和总IgE抗体,免疫印迹法检测20种变应原sIgE抗体,化学微粒子发光法检测甲状腺过氧化物酶IgG抗体和甲状腺球蛋白IgG抗体。两组间和多组间正态分布计量数据的比较分别采用t检验和单因素方差分析,两组间非正态分布计量数据的比较采用Mann-Whitney U检验,率的比较采用χ2检验和Fisher精确检验。结果纳入CSU患者248例,SD患者22例,AU患者15例,健康对照13例。以sIgG≥100 IU/ml(2+及以上)为阳性标准,CSU组、SD组和AU组的食物sIgG阳性率(176/248,70.97%;15/22,68.18%;11/15)略高于健康对照组(7/13),但4组差异无统计学意义(χ2=1.80,P=0.615)。248例CSU患者中,sIgG阳性组有过敏性疾病家族史的比例(71/176,40.34%)显著高于sIgG阴性组(19/72,26.39%;χ2=4.30,P=0.042),但两组1 d荨麻疹活动度评分(UASday)差异无统计学意义(Z=0.18,P=0.859)。177例CSU患者完成12~40周的治疗及随访且使用二代抗组胺药物可完全控制病情,sIgG阳性组(128例)与sIgG阴性组(49例)所需剂量差异无统计学意义(Z=-1.06,P=0.298)。结论食物sIgG阳性的CSU患者有过敏性疾病家族史的比例升高,但食物sIgG不能作为反映CSU疾病活动度和治疗反应的指标。 展开更多
关键词 荨麻疹 慢性自发性荨麻疹 皮肤划痕症 急性荨麻疹 食物特异性IGG 甲状腺过氧化物酶 甲状腺球蛋白 总IGE 变应原特异性IgE
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云南地区化妆品不良反应96例临床特征分析 被引量:6
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作者 杨雅琪 涂颖 +4 位作者 王红云 农祥 陈绍华 何黎 顾华 《中国皮肤性病学杂志》 CAS CSCD 北大核心 2022年第6期660-663,共4页
目的探讨2020年本院96例化妆品皮肤不良反应的临床特点,为科学防治化妆品不良反应及化妆品安全风险监管提供依据和建议。方法分析2020年本院收集及上报的96例化妆品皮肤不良反应患者的临床资料和斑贴试验等结果。结果化妆品皮肤不良反... 目的探讨2020年本院96例化妆品皮肤不良反应的临床特点,为科学防治化妆品不良反应及化妆品安全风险监管提供依据和建议。方法分析2020年本院收集及上报的96例化妆品皮肤不良反应患者的临床资料和斑贴试验等结果。结果化妆品皮肤不良反应患者共96例,其中女性(97.92%)明显高于男性(2.08%),年龄主要集中于21~49岁(94.79%);不良反应临床诊断为化妆品接触性皮炎占79.17%,其余依次为皮肤色素异常(12.50%)、痤疮(5.21%)及毛发损害(3.13%);仅7例完成化妆品斑贴试验,阳性率71.43%;在110种可疑致病化妆品中,非特殊用途占68.18%,特殊用途占31.82%,无批准文号占41.82%;可疑致病化妆品来源,网购占70.91%,美容美发机构占16.36%,商场占12.73%。结论化妆品不良反应常发生于中青年女性;接触性皮炎是最常见的化妆品皮肤不良反应;可疑致病特殊用途化妆品中,以祛斑类居多;斑贴试验仅可作为诊断化妆品接触性皮炎的检验方法,诊断化妆品致其他皮肤病的检验方法仍有待完善;应加强科学护肤和安全使用化妆品的宣教;应规范化妆品销售渠道。 展开更多
关键词 化妆品 斑贴试验 化妆品不良反应 临床特征 化妆品特征
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