In this study, exogenous pre-harvest treatment of tomato plants with MeJA （Methyl Jasmonate） and chitosan was used to elicit lycopene biosynthesis and stimulate plant growth. Lycopene is a bright red carotene and ca...In this study, exogenous pre-harvest treatment of tomato plants with MeJA （Methyl Jasmonate） and chitosan was used to elicit lycopene biosynthesis and stimulate plant growth. Lycopene is a bright red carotene and carotenoid pigment found in tomatoes, carrots and other red fruits and vegetables. It is a powerful antioxidant that protects cells from damage and blocks cancerous cell growth. Many studies suggest eating lycopene-rich foods may be directly linked to reducing risk of several cancers, heart disease and stroke, hence there is a need to enhance its levels in tomatoes. Tomato seeds were soaked in MeJA and chitosan solutions of varying concentrations and then planted. The resulting plants were irrigated with the solutions used to soak the seeds, accordingly. The heights of the plants were recorded on a tri-weekly basis and HPLC （High Performance Liquid Chromatography） was used to analyze the effects of the MeJA and chitosan solutions on lycopene yields in the tomato fruits. Analysis of chromatograms obtained from tomato samples in the MeJA and chitosan-treated groups showed enhanced levels of lycopene. Plant growth was not significantly affected by treatment ofMeJA. Chitosan, however, noticeably increased plant growth over 7 weeks.展开更多
Triple Negative Breast Cancer(TNBC)is the most lethal subtype of breast cancer.Despite the successes of emerging targeted therapies,relapse,recurrence,and therapy failure rates in TNBC significantly outpace other subt...Triple Negative Breast Cancer(TNBC)is the most lethal subtype of breast cancer.Despite the successes of emerging targeted therapies,relapse,recurrence,and therapy failure rates in TNBC significantly outpace other subtypes of breast cancer.Mounting evidence suggests accumulation of therapy resistant Cancer Stem Cell(CSC)populations within TNBCs contributes to poor clinical outcomes.These CSCs are enriched in TNBC compared to non-TNBC breast cancers.The mechanisms underlying CSC accumulation have been well-characterized and discussed in other reviews.In this review,we focus on TNBC-specific mechanisms that allow the expansion and activity of self-renewing CSCs.We highlight cellular signaling pathways and transcription factors,specifically enriched in TNBC over non-TNBC breast cancer,contributing to stemness.We also analyze publicly available single-cell RNA-seq data from basal breast cancer tumors to highlight the potential of emerging bioinformatic approaches in identifying novel drivers of stemness in TNBC and other cancers.展开更多
文摘In this study, exogenous pre-harvest treatment of tomato plants with MeJA （Methyl Jasmonate） and chitosan was used to elicit lycopene biosynthesis and stimulate plant growth. Lycopene is a bright red carotene and carotenoid pigment found in tomatoes, carrots and other red fruits and vegetables. It is a powerful antioxidant that protects cells from damage and blocks cancerous cell growth. Many studies suggest eating lycopene-rich foods may be directly linked to reducing risk of several cancers, heart disease and stroke, hence there is a need to enhance its levels in tomatoes. Tomato seeds were soaked in MeJA and chitosan solutions of varying concentrations and then planted. The resulting plants were irrigated with the solutions used to soak the seeds, accordingly. The heights of the plants were recorded on a tri-weekly basis and HPLC （High Performance Liquid Chromatography） was used to analyze the effects of the MeJA and chitosan solutions on lycopene yields in the tomato fruits. Analysis of chromatograms obtained from tomato samples in the MeJA and chitosan-treated groups showed enhanced levels of lycopene. Plant growth was not significantly affected by treatment ofMeJA. Chitosan, however, noticeably increased plant growth over 7 weeks.
文摘Triple Negative Breast Cancer(TNBC)is the most lethal subtype of breast cancer.Despite the successes of emerging targeted therapies,relapse,recurrence,and therapy failure rates in TNBC significantly outpace other subtypes of breast cancer.Mounting evidence suggests accumulation of therapy resistant Cancer Stem Cell(CSC)populations within TNBCs contributes to poor clinical outcomes.These CSCs are enriched in TNBC compared to non-TNBC breast cancers.The mechanisms underlying CSC accumulation have been well-characterized and discussed in other reviews.In this review,we focus on TNBC-specific mechanisms that allow the expansion and activity of self-renewing CSCs.We highlight cellular signaling pathways and transcription factors,specifically enriched in TNBC over non-TNBC breast cancer,contributing to stemness.We also analyze publicly available single-cell RNA-seq data from basal breast cancer tumors to highlight the potential of emerging bioinformatic approaches in identifying novel drivers of stemness in TNBC and other cancers.
