Objective C/eome rutidosperma （Capparidaceae）, commonly known as ＂Fringed Spider Flower＂, is a medicinal plant found in Southeast Asia. C. rutidosperma is used in folk medicine for diuretic, laxative, analgesic, a...Objective C/eome rutidosperma （Capparidaceae）, commonly known as ＂Fringed Spider Flower＂, is a medicinal plant found in Southeast Asia. C. rutidosperma is used in folk medicine for diuretic, laxative, analgesic, anti-inflammatory, antipyretic, antimicrobial, anti-oxidant, hypoglycemic, and anthelmintic activities. We have evaluated the anti-nociceptive properties of methanol extract from C. rutidosperma （MECR） in vivo. Methods Thermal method （hot plate test and tail flick test） was induced to judge the anti-inflammatory effect and couple of chemical method also used （formalin induced licking test; writhing test carried by acetic acid） to evaluate analgesic effect. Both of these tests were made over animal models, like mice and rats. Two different doses （1 O0 and 200 mg/kg） were used for each case of test, while morphine sulphate （5mg/kg, ip） was used as reference drug. Results MECR demonstrated the significantly anti-nociceptive activity in the analgesic and anti-inflammatory tests by reducing nociception in mice models （P 〈 0.001）. in the hot-plate and tail-flick tests, MECR significantly elongated the time to response to the thermal stimuli （100 and 200 mg/kg with P 〈 0.05, 0.001）. The remarkable increase in the latency was observed at 90 and 120 min. In acetic acid-induced writhing test and formalin induced licking test for anti-inflammatory activity, MECR at 100 and 200 mg/kg doses exhibited significant （P〈 0.001） reduction of writhing and licking response. Conclusion The anti-inflammatory and analgesic effects of C. rutidosperma propose that this effect may be a result of both peripheral and central mechanisms. Further study is required to ensure the proper mechanism of action as well as the active ingredient.展开更多
文摘Objective C/eome rutidosperma （Capparidaceae）, commonly known as ＂Fringed Spider Flower＂, is a medicinal plant found in Southeast Asia. C. rutidosperma is used in folk medicine for diuretic, laxative, analgesic, anti-inflammatory, antipyretic, antimicrobial, anti-oxidant, hypoglycemic, and anthelmintic activities. We have evaluated the anti-nociceptive properties of methanol extract from C. rutidosperma （MECR） in vivo. Methods Thermal method （hot plate test and tail flick test） was induced to judge the anti-inflammatory effect and couple of chemical method also used （formalin induced licking test; writhing test carried by acetic acid） to evaluate analgesic effect. Both of these tests were made over animal models, like mice and rats. Two different doses （1 O0 and 200 mg/kg） were used for each case of test, while morphine sulphate （5mg/kg, ip） was used as reference drug. Results MECR demonstrated the significantly anti-nociceptive activity in the analgesic and anti-inflammatory tests by reducing nociception in mice models （P 〈 0.001）. in the hot-plate and tail-flick tests, MECR significantly elongated the time to response to the thermal stimuli （100 and 200 mg/kg with P 〈 0.05, 0.001）. The remarkable increase in the latency was observed at 90 and 120 min. In acetic acid-induced writhing test and formalin induced licking test for anti-inflammatory activity, MECR at 100 and 200 mg/kg doses exhibited significant （P〈 0.001） reduction of writhing and licking response. Conclusion The anti-inflammatory and analgesic effects of C. rutidosperma propose that this effect may be a result of both peripheral and central mechanisms. Further study is required to ensure the proper mechanism of action as well as the active ingredient.
