Wound management is a crucial measure for skin wound healing and is significantly important to maintaining the integrity of skins and their functions.Electrical stimulation at the wound site is a compelling strategy f...Wound management is a crucial measure for skin wound healing and is significantly important to maintaining the integrity of skins and their functions.Electrical stimulation at the wound site is a compelling strategy for skin wound repair.However,there has been an urgent need for wearable and point-of-care electrical stimulation devices that have self-adhesive and mechanical properties comparable to wound tissue.Herein,we develop a bioinspired hybrid patch with self-adhesive and piezoelectric nanogenerator(HPSP)for promoting skin wound healing,which is composed of a mussel-inspired hydrogel matrix and a piezoelectric nanogenerator based on aligned electrospun poly(vinylidene fluoride)nanofibers.The device with optimized modulus and permeability for skin wear can self-adhere to the wound site and locally produce a dynamic voltage caused by motion.We show that the HPSP not only promotes fibroblast proliferation and migration in vitro,but also effectively facilitates the collagen deposition,angiogenesis,and re-epithelialization in vivo with the increased expressions of crucial growth factors.The HPSP reduces the wound closure time of full-thickness skin defects by about 1/3,greatly accelerating the healing process.This patch can serve as wearable and real-time electrical stimulation devices,potentially useful in clinical applications of skin wound healing.展开更多
Utilizing photothermal hydrogels as a wound dressing is a promising strategy to accelerate wound healing.Usually,a photothermal hydrogel has a strong light-absorbing capability,and hence its transparency can be largel...Utilizing photothermal hydrogels as a wound dressing is a promising strategy to accelerate wound healing.Usually,a photothermal hydrogel has a strong light-absorbing capability,and hence its transparency can be largely sacrificed,which is unbeneficial for the visual monitoring of wound states.It remains challenging to balance the trade-off between the photothermal conversion and wound visualization for the photothermal hydrogel dressing.Herein,a composite photothermal hydrogel film with high transparency is presented for the visual monitor of the wound,which is constructed by incorporating CsxW03 nanorods into the networks of polyacrylamide hydrogels.The composite photothermal hydrogel film exhibits high light absorption in the near-infrared region and high transmittance in the visible light region.Under 980 nm laser irradiation,the composite hydrogel can be heated up to 45°C.In vivo animal experiment on mouse skin wound model shows that the composite hydrogel film can locally heat the skin wound to accelerate healing while maintaining more than 70%transparency to realize real-time observation of the wound.This study provides the first attempt to solve the problem of opacity in photothermal hydrogel dressings,promoting the possibility of its clinical applications.展开更多
基金We thank the funding support from the National Natural Science Foundation of China(Nos.51973075 and 51525302)Program for HUST Academic Frontier Youth Team(2015-01)The authors thank HUST Analytical and Testing Center for their supports on the facilities.
文摘Wound management is a crucial measure for skin wound healing and is significantly important to maintaining the integrity of skins and their functions.Electrical stimulation at the wound site is a compelling strategy for skin wound repair.However,there has been an urgent need for wearable and point-of-care electrical stimulation devices that have self-adhesive and mechanical properties comparable to wound tissue.Herein,we develop a bioinspired hybrid patch with self-adhesive and piezoelectric nanogenerator(HPSP)for promoting skin wound healing,which is composed of a mussel-inspired hydrogel matrix and a piezoelectric nanogenerator based on aligned electrospun poly(vinylidene fluoride)nanofibers.The device with optimized modulus and permeability for skin wear can self-adhere to the wound site and locally produce a dynamic voltage caused by motion.We show that the HPSP not only promotes fibroblast proliferation and migration in vitro,but also effectively facilitates the collagen deposition,angiogenesis,and re-epithelialization in vivo with the increased expressions of crucial growth factors.The HPSP reduces the wound closure time of full-thickness skin defects by about 1/3,greatly accelerating the healing process.This patch can serve as wearable and real-time electrical stimulation devices,potentially useful in clinical applications of skin wound healing.
基金The authors are thankful to the HUST Analytical and Testing Center for their help with the facilities.We thank the funding support from the National Natural Science Foundation of China(Grant No.52022032).
文摘Utilizing photothermal hydrogels as a wound dressing is a promising strategy to accelerate wound healing.Usually,a photothermal hydrogel has a strong light-absorbing capability,and hence its transparency can be largely sacrificed,which is unbeneficial for the visual monitoring of wound states.It remains challenging to balance the trade-off between the photothermal conversion and wound visualization for the photothermal hydrogel dressing.Herein,a composite photothermal hydrogel film with high transparency is presented for the visual monitor of the wound,which is constructed by incorporating CsxW03 nanorods into the networks of polyacrylamide hydrogels.The composite photothermal hydrogel film exhibits high light absorption in the near-infrared region and high transmittance in the visible light region.Under 980 nm laser irradiation,the composite hydrogel can be heated up to 45°C.In vivo animal experiment on mouse skin wound model shows that the composite hydrogel film can locally heat the skin wound to accelerate healing while maintaining more than 70%transparency to realize real-time observation of the wound.This study provides the first attempt to solve the problem of opacity in photothermal hydrogel dressings,promoting the possibility of its clinical applications.
