Objective:This study was undertaken to assess if levels of interleukin-1β(IL-1β),IL-8,sialidase,prolidase and immunoglobulin A against Gardenerella vaginalis hemolysin (anti-Gvh IgA) in vaginal secretions differ bet...Objective:This study was undertaken to assess if levels of interleukin-1β(IL-1β),IL-8,sialidase,prolidase and immunoglobulin A against Gardenerella vaginalis hemolysin (anti-Gvh IgA) in vaginal secretions differ between BV+women with (M+) and without (M-) Mobiluncus spp. Study design:Vaginal secretions were obtained from 265 women at their first prenatal care visit and assessed for all study parameters. Gram stain evaluation using Nugent criteria was performed and coinfection with sexually transmitted infections determined. Differences between BV+/M+and BV+/M-women were evaluated using the χ2 statistic or Mann-Whitney test. Results:Of the 265 BV+women,43%(n = 113) were M+of which 97%(n = 110) had Nugent scores of 9 or 10 . BV+/M+women had elevated levels of sialidase (median value:4.11 nmol vs 1.91 nmol of converted substrate; P = .003) but no difference in prolidase,anti-Gvh IgA,IL-1β,IL-8,levels were found between the two groups. BV+/M-women had significantly higher rates of coinfection with Trichomonas vaginalis. Conclusion:BV+/M+women have higher vaginal concentrations of sialidase and lower rates of T vaginalis compared with BV+/M-women. Further research is needed to assess the association of this,and other,microbiologic profiles to risk of adverse pregnancy outcome.展开更多
Objective: The purpose of this study was to determine the effects of 3 intravaginal antibacterial treatments on vaginal lactobacilli in patients with bacterial vaginosis (BV). Study design:Retrospective analyses were ...Objective: The purpose of this study was to determine the effects of 3 intravaginal antibacterial treatments on vaginal lactobacilli in patients with bacterial vaginosis (BV). Study design:Retrospective analyses were performed on Lactobacillus scores from 3 similar studies evaluating 22% clindamycin vaginal creams and 0.75% metronidazole gel at baseline and at 21 to 30 days in 408 patients with BV. Scores were compared using a 1- way global F test and Mc-Nemar s test. Results: All groups had similar mean Lactobacillus scores at baseline (P = 0.37) and at 21 to 30 days (P = .71). The 3 groups were also comparable at both visits with respect to the distributions of scores within each group. In all groups, there was significant improvement in the percentages of patients with no lactobacilli present at 21 to 30 days compared with baseline (P < .0001 for all comparisons).Conclusion: Clindamycin and metronidazole promoted similar levels of restoration of vaginal lactobacilli at 21 to 30 days.展开更多
文摘Objective:This study was undertaken to assess if levels of interleukin-1β(IL-1β),IL-8,sialidase,prolidase and immunoglobulin A against Gardenerella vaginalis hemolysin (anti-Gvh IgA) in vaginal secretions differ between BV+women with (M+) and without (M-) Mobiluncus spp. Study design:Vaginal secretions were obtained from 265 women at their first prenatal care visit and assessed for all study parameters. Gram stain evaluation using Nugent criteria was performed and coinfection with sexually transmitted infections determined. Differences between BV+/M+and BV+/M-women were evaluated using the χ2 statistic or Mann-Whitney test. Results:Of the 265 BV+women,43%(n = 113) were M+of which 97%(n = 110) had Nugent scores of 9 or 10 . BV+/M+women had elevated levels of sialidase (median value:4.11 nmol vs 1.91 nmol of converted substrate; P = .003) but no difference in prolidase,anti-Gvh IgA,IL-1β,IL-8,levels were found between the two groups. BV+/M-women had significantly higher rates of coinfection with Trichomonas vaginalis. Conclusion:BV+/M+women have higher vaginal concentrations of sialidase and lower rates of T vaginalis compared with BV+/M-women. Further research is needed to assess the association of this,and other,microbiologic profiles to risk of adverse pregnancy outcome.
文摘Objective: The purpose of this study was to determine the effects of 3 intravaginal antibacterial treatments on vaginal lactobacilli in patients with bacterial vaginosis (BV). Study design:Retrospective analyses were performed on Lactobacillus scores from 3 similar studies evaluating 22% clindamycin vaginal creams and 0.75% metronidazole gel at baseline and at 21 to 30 days in 408 patients with BV. Scores were compared using a 1- way global F test and Mc-Nemar s test. Results: All groups had similar mean Lactobacillus scores at baseline (P = 0.37) and at 21 to 30 days (P = .71). The 3 groups were also comparable at both visits with respect to the distributions of scores within each group. In all groups, there was significant improvement in the percentages of patients with no lactobacilli present at 21 to 30 days compared with baseline (P < .0001 for all comparisons).Conclusion: Clindamycin and metronidazole promoted similar levels of restoration of vaginal lactobacilli at 21 to 30 days.
