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右美托咪定和地塞米松作为臂丛神经阻滞添加剂的临床疗效 被引量:7
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作者 冯兆森 方育 +3 位作者 欧顶琴 杨轶涵 王志瑶 黄洁 《昆明医科大学学报》 CAS 2021年第10期68-75,共8页
目的探讨添加右美托咪定(dexmedetomidine,DEX)或地塞米松(dexamethasone,DXM)对肌间沟臂丛神经阻滞临床效果的影响。方法随机将拟行超声引导下肌间沟臂丛阻滞的患者50例,按局麻药配方不同分为5组:R组(对照组,0.5%罗哌卡因20 mL,n=10);R... 目的探讨添加右美托咪定(dexmedetomidine,DEX)或地塞米松(dexamethasone,DXM)对肌间沟臂丛神经阻滞临床效果的影响。方法随机将拟行超声引导下肌间沟臂丛阻滞的患者50例,按局麻药配方不同分为5组:R组(对照组,0.5%罗哌卡因20 mL,n=10);R+LDEX组(0.5%罗哌卡因+1μg/kg DEX共20 mL,n=10);R+HDEX组(0.5%罗哌卡因+2μg/kg DEX共20 mL,n=10);R+LDXM组(0.5%罗哌卡因+4 mg DXM共20 mL,n=10);R+HDXM组(0.5%罗哌卡因+8 mg DXM共20 mL,n=10)。结果与其他组比较,R+LDEX组和R+HDEX组阻滞起效时间显著缩短(P<0.05);与R组比较,4个实验组均显著延长阻滞作用时间(P<0.01);术后12、24 h VAS评分和自控镇痛使用次数4个实验组明显低于R组,(P<0.001);阻滞后5 min R+HDEX组患者HR降低,并持续至30 min(P<0.05);R+LDEX和R+HDEX组在阻滞后5、10、15 min SBP、DBP和MAP升高(P<0.05);注射局麻药后5 min,R+LDEX和R+HDEX组患者出现BIS降低并持续至30 min(P<0.001),R+HDEX组BIS降低较R+LDEX组更为明显。结论局麻药添加DEX和DXM均能显著延长臂丛神经阻滞作用时间;DEX可以缩短肌间沟臂丛阻滞起效时间并引起血压一过性升高;DEX呈剂量依赖性的产生中枢镇静作用。 展开更多
关键词 右美托咪定 地塞米松 臂丛神经阻滞
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The protective effect of ginsenoside Rb1 pre-treatment on myocardial ischemia/reperfusion injury in Sprague-Dawley rats
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作者 FANG Pin-hao LI Chang-yan +2 位作者 YANG Jia-ni MENG Wen-ting ou ding-qin 《South China Journal of Cardiology》 CAS 2020年第1期53-59,66,共8页
Background Myocardial ischemia/reperfusion injury(MI/RI)during myocardial infarction worsens outcomes. It has been proved that ginsenoside Rb1 has a great impact on ischemia/reperfusion(I/R)injury. The aim of this stu... Background Myocardial ischemia/reperfusion injury(MI/RI)during myocardial infarction worsens outcomes. It has been proved that ginsenoside Rb1 has a great impact on ischemia/reperfusion(I/R)injury. The aim of this study is to explore the protective effect of the pretreatment with ginsenoside Rb1 on MI/RI and investigate the underlying mechanisms about the preventive action. Methods A total of 27 healthy adult Sprague-Dawley(SD)rats were randomly divided into 3 groups(n=9 per group):A sham-operated group(Sham n=9);an ischemia 40 min/reperfusion 2 h(I/R n=9)of the cardiac muscle group;Rb1-treated group was divided into 3 subgroups(Rb1 10 mg/kg,20 mg/kg,40 mg/kg,n=3). Ginsenosides Rb1 at different concentrations were injected intraperitoneally for 3 days continuously before ligation. A model of MI/RI was constructed by ligation of the left coronary artery anterior descending branch in rats. Myocardial infarction area after I/R was measured bytriphenyltetrazolium chloride(TTC)staining of myocardial tissue. Hematoxylin and eosin(HE)staining and electrocardiogram indication were used to observe myocardial cell injury and ischemia,respectively. The expression of caspase-8 protein was observed by immunohistochemistry staining. Results The pretreatment of 40 mg/kg dose of ginsenoside Rb1 could decrease the expression of caspase-8 protein caused by I/R and the apoptosis of myocardial cells,improve myocardial ischemia,reduce the area of myocardial infarction and ameliorate MI/RI.Conclusions These results demonstrate that ginsenoside Rb1 has a significant protective effect on MI/RI through attenuating the apoptosis of myocardial cells and improving myocardial ischemia at appropriate dose,which provides new insights into the potential therapy of MI/RI. 展开更多
关键词 myocardial ischemia/reperfusion injury ginsenoside Rb1 caspase-8 protein TTC staining HE staining
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