Biliary atresia(BA)is one of the most common and enigmatic forms of neonatal cholestasis and is characterized by inflammation and obstruction of extrahepatic bile ducts resulting in biliary cirrhosis,which occurs in 1...Biliary atresia(BA)is one of the most common and enigmatic forms of neonatal cholestasis and is characterized by inflammation and obstruction of extrahepatic bile ducts resulting in biliary cirrhosis,which occurs in 1 in 8,000 to 1 in 18,000 live births.Revealing of the mechanisms underlying BA is crucial for early diagnosis,intervention,and better prognosis.The etiology of BA remains unclear,and currently,noncoding and epigenetic factors,rather than classic genetic alterations,are assumed to be responsible for genetic predisposition to BA.展开更多
基金supported by the Medical Science and Technology Research Foundation of Guangdong Province[No.2017A020214017]。
文摘Biliary atresia(BA)is one of the most common and enigmatic forms of neonatal cholestasis and is characterized by inflammation and obstruction of extrahepatic bile ducts resulting in biliary cirrhosis,which occurs in 1 in 8,000 to 1 in 18,000 live births.Revealing of the mechanisms underlying BA is crucial for early diagnosis,intervention,and better prognosis.The etiology of BA remains unclear,and currently,noncoding and epigenetic factors,rather than classic genetic alterations,are assumed to be responsible for genetic predisposition to BA.
