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Drugging in the absence of p53 被引量:6
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作者 obed akwasi aning Chit Fang Cheok 《Journal of Molecular Cell Biology》 SCIE CAS CSCD 2019年第3期255-264,共10页
Inactivation of the p53 gene is a key driver of tumorigenesis in various cancer cohorts and types.The quest for a successful p53-based therapy that holds the promise of treating more than half of the cancer population... Inactivation of the p53 gene is a key driver of tumorigenesis in various cancer cohorts and types.The quest for a successful p53-based therapy that holds the promise of treating more than half of the cancer population has culminated in extensive knowledge about the role and function of p53 and led to new proposed innovative strategies against p53-defective cancers.We will discuss some of these latest studies with a focus on metabolic regulation and DNA damage response and also highlight novel functions of p53 in these pathways that may provide a contemporary rationale for targeting p53 loss in tumors. 展开更多
关键词 THERAPEUTICS METABOLISM DNA damage REPLICATION stress P53 synthetic LETHALITY
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