Background/Aims: To evaluate the therapeutic efficacy of percutaneous ethanol injection (PEI) for patients with ≤ 3 lesions of small (≤ 3 cm diameter) hepatocellular carcinoma (HCC). Methods: PEI was applied to 270 ...Background/Aims: To evaluate the therapeutic efficacy of percutaneous ethanol injection (PEI) for patients with ≤ 3 lesions of small (≤ 3 cm diameter) hepatocellular carcinoma (HCC). Methods: PEI was applied to 270 patients with small HCC as the first-line treatment option during a 20-year period. Results: (1) There was no treatment-related deaths, and only 2.2% of severe complications; (2) PEI induced a complete response of all HCCs according to CT evaluation performed within one month after the procedure, and the local recurrence rate at 3 years was 10% ; (3) the overall 3-and 5-year survival rates after treatment were 81.6 and 60.3% , respectively, but the rates were higher, 87.3 and 78.3% , in Child A patients with a solitary tumor ≤ 2 cm in diameter; (4) factors significantly influencing survival were liver function (P=0.0033) and serum alpha-fetoprotein level (P=0.0014), and (5) the recurrence rate at remote sites in the liver was lower in patients with HCC ≤ 2 cm(P=0.0395) and in those with a solitary HCC (P< 0.0001) according to Cox’ s proportional hazard model. (6) Radiofrequency ablation would not have been performed in approximately 25% of these patients. Conclusions: PEI is considered a reliable treatment for small HCC in terms of safety and efficacy.展开更多
文摘Background/Aims: To evaluate the therapeutic efficacy of percutaneous ethanol injection (PEI) for patients with ≤ 3 lesions of small (≤ 3 cm diameter) hepatocellular carcinoma (HCC). Methods: PEI was applied to 270 patients with small HCC as the first-line treatment option during a 20-year period. Results: (1) There was no treatment-related deaths, and only 2.2% of severe complications; (2) PEI induced a complete response of all HCCs according to CT evaluation performed within one month after the procedure, and the local recurrence rate at 3 years was 10% ; (3) the overall 3-and 5-year survival rates after treatment were 81.6 and 60.3% , respectively, but the rates were higher, 87.3 and 78.3% , in Child A patients with a solitary tumor ≤ 2 cm in diameter; (4) factors significantly influencing survival were liver function (P=0.0033) and serum alpha-fetoprotein level (P=0.0014), and (5) the recurrence rate at remote sites in the liver was lower in patients with HCC ≤ 2 cm(P=0.0395) and in those with a solitary HCC (P< 0.0001) according to Cox’ s proportional hazard model. (6) Radiofrequency ablation would not have been performed in approximately 25% of these patients. Conclusions: PEI is considered a reliable treatment for small HCC in terms of safety and efficacy.
