Objective: To evaluate the efficacy of a cognitive-motor program in patients with early Alzheimer disease (AD) who are treated with a cholinesterase inhibito r (ChEI). Methods: Patients with mild cognitive impairment ...Objective: To evaluate the efficacy of a cognitive-motor program in patients with early Alzheimer disease (AD) who are treated with a cholinesterase inhibito r (ChEI). Methods: Patients with mild cognitive impairment (MCI) (12), mild AD(4 8), and moderate AD (24) (Global Deterioration Scale stages 3, 4, and 5) were ra ndomized to receive psychosocial support plus cognitive-motor intervention (exp erimental group) or psychosocial support alone (control group). Cognitive-motor intervention (CMI) consisted of a 1-year structured program of 103 sessions of cognitive exercises, plus social and psychomotor activities. The primary effica cy measure was the cognitive subscale of the AD Assessment Scale (ADAS-cog). Se condary efficacy measures were the Mini-Mental State Examination,the Functional Activities Questionnaire, and the Geriatric Depression Scale. Evaluations were conducted at 1, 3, 6, and 12 months by blinded evaluators. Results: Patients in the CMI group maintained cognitive status at month 6, whereas patients in the co ntrol group had significantly declined at that time.Cognitive response was highe r in the patients with fewer years of formal education. In addition, more patien ts in the experimental group maintained or improved their affective status at mo nth 12 (experimental group, 75%; control group, 47%; p =0.017). Conclusions: A long-term CMI in ChEI-treated early Alzheimer disease patients produced addit ional mood and cognitive benefits.展开更多
文摘Objective: To evaluate the efficacy of a cognitive-motor program in patients with early Alzheimer disease (AD) who are treated with a cholinesterase inhibito r (ChEI). Methods: Patients with mild cognitive impairment (MCI) (12), mild AD(4 8), and moderate AD (24) (Global Deterioration Scale stages 3, 4, and 5) were ra ndomized to receive psychosocial support plus cognitive-motor intervention (exp erimental group) or psychosocial support alone (control group). Cognitive-motor intervention (CMI) consisted of a 1-year structured program of 103 sessions of cognitive exercises, plus social and psychomotor activities. The primary effica cy measure was the cognitive subscale of the AD Assessment Scale (ADAS-cog). Se condary efficacy measures were the Mini-Mental State Examination,the Functional Activities Questionnaire, and the Geriatric Depression Scale. Evaluations were conducted at 1, 3, 6, and 12 months by blinded evaluators. Results: Patients in the CMI group maintained cognitive status at month 6, whereas patients in the co ntrol group had significantly declined at that time.Cognitive response was highe r in the patients with fewer years of formal education. In addition, more patien ts in the experimental group maintained or improved their affective status at mo nth 12 (experimental group, 75%; control group, 47%; p =0.017). Conclusions: A long-term CMI in ChEI-treated early Alzheimer disease patients produced addit ional mood and cognitive benefits.
