We investigated the predicted function of proteins eluded from human MHC class Ⅱ molecules.Peptides that are presented by MHC class Ⅱ were obtained from the SYFPEITHI database and the corresponding proteins were fou...We investigated the predicted function of proteins eluded from human MHC class Ⅱ molecules.Peptides that are presented by MHC class Ⅱ were obtained from the SYFPEITHI database and the corresponding proteins were found in the SWISSPROT database.The functions of these proteins were predicted using the protfun server.Our analysis showed that human proteins presented by MHC class Ⅱ molecules are likely to be in the cell envelope,be a receptor or involved in immune responses.Presented proteins from bacteria and virus,on the other hand,are more likely to be involved in regulatory functions,translation,transcription as well as replication.These results can lead to better understanding the autoimmunity and the response to infections.Cellular & Molecular Immunology.2005; 2(1):49-56.展开更多
文摘We investigated the predicted function of proteins eluded from human MHC class Ⅱ molecules.Peptides that are presented by MHC class Ⅱ were obtained from the SYFPEITHI database and the corresponding proteins were found in the SWISSPROT database.The functions of these proteins were predicted using the protfun server.Our analysis showed that human proteins presented by MHC class Ⅱ molecules are likely to be in the cell envelope,be a receptor or involved in immune responses.Presented proteins from bacteria and virus,on the other hand,are more likely to be involved in regulatory functions,translation,transcription as well as replication.These results can lead to better understanding the autoimmunity and the response to infections.Cellular & Molecular Immunology.2005; 2(1):49-56.
