In the course of the study there were examined cytokine levels of pro-inflammatory and anti-inflammatory activity (IL-1b, IL-4, IL-6, IL-8, IL-10, IFN-g, G-GSF), and also the levels of progesterone and estradiol in th...In the course of the study there were examined cytokine levels of pro-inflammatory and anti-inflammatory activity (IL-1b, IL-4, IL-6, IL-8, IL-10, IFN-g, G-GSF), and also the levels of progesterone and estradiol in the blood serum with a view to study the pathogenic characteristics of a chronic inflammatory process of the pelvic organs in remission. It was shown that the remission of the disease is characterized by the significant increase in the concentrations of pro-inflammatory cytokines IL-6, IL-8, and also increase of inducers activation of the immune response of the immune response (IL-4 and IFN-g), accompanied by a decrease in the concentration of sex hormones. In women with chronic inflammatory diseases of urogenital sphere in remission tested active immunological process and violation of the synthesis of sex hormones. Revealed changes predispose to the emergence disorders of reproductive health.展开更多
There were investigated levels of pro-inflammatory and regulatory cytokines (IL-1b, IL-6 and IFN-g) in women of reproductive age in periods of exacerbation and remission of chronic infection caused by the herpes simpl...There were investigated levels of pro-inflammatory and regulatory cytokines (IL-1b, IL-6 and IFN-g) in women of reproductive age in periods of exacerbation and remission of chronic infection caused by the herpes simplex virus in purpose to study the pathogenetic features of the course of HSV infection. It is shown that both the period of exacerbation, and the period of clinical remission of chronic herpes infection are characterized by increased production of IFN-g, IL-1b and IL-6. However, only the mean values of IL-1b were significantly different in periods of exacerbation and remission. Moreover, patients with chronic herpes infection revealed significant heterogeneity of individual values of measured cytokines (IL-1b, IL-6 and IFN-g), which does not depend on the period of clinical disease.展开更多
In the purpose of studing the pathogenetic features of the pathological process there were investigated cytokine levels with proinflammatory and anti-inflammatory activity, and also the indicators of endothelial dysfu...In the purpose of studing the pathogenetic features of the pathological process there were investigated cytokine levels with proinflammatory and anti-inflammatory activity, and also the indicators of endothelial dysfunction in blood serum women with moderate and severe preeclampsia. There were found high concentrations of pro-inflammatory cytokines IL-1β, IL-6 and IL-8, and vascular endothelial adhesion molecule-1 (sVCAM-1), which correlated with the severity of the process. Also a significant decrease in concentrations TGF-β2 and IL-10 insevere preeclampsia was indicated, which may testify the exhaustion of adaptive mechanisms and, apparently, can be an additional diagnostic criterion for the prediction and assessment of the severity of the pathological process.展开更多
文摘In the course of the study there were examined cytokine levels of pro-inflammatory and anti-inflammatory activity (IL-1b, IL-4, IL-6, IL-8, IL-10, IFN-g, G-GSF), and also the levels of progesterone and estradiol in the blood serum with a view to study the pathogenic characteristics of a chronic inflammatory process of the pelvic organs in remission. It was shown that the remission of the disease is characterized by the significant increase in the concentrations of pro-inflammatory cytokines IL-6, IL-8, and also increase of inducers activation of the immune response of the immune response (IL-4 and IFN-g), accompanied by a decrease in the concentration of sex hormones. In women with chronic inflammatory diseases of urogenital sphere in remission tested active immunological process and violation of the synthesis of sex hormones. Revealed changes predispose to the emergence disorders of reproductive health.
文摘There were investigated levels of pro-inflammatory and regulatory cytokines (IL-1b, IL-6 and IFN-g) in women of reproductive age in periods of exacerbation and remission of chronic infection caused by the herpes simplex virus in purpose to study the pathogenetic features of the course of HSV infection. It is shown that both the period of exacerbation, and the period of clinical remission of chronic herpes infection are characterized by increased production of IFN-g, IL-1b and IL-6. However, only the mean values of IL-1b were significantly different in periods of exacerbation and remission. Moreover, patients with chronic herpes infection revealed significant heterogeneity of individual values of measured cytokines (IL-1b, IL-6 and IFN-g), which does not depend on the period of clinical disease.
文摘In the purpose of studing the pathogenetic features of the pathological process there were investigated cytokine levels with proinflammatory and anti-inflammatory activity, and also the indicators of endothelial dysfunction in blood serum women with moderate and severe preeclampsia. There were found high concentrations of pro-inflammatory cytokines IL-1β, IL-6 and IL-8, and vascular endothelial adhesion molecule-1 (sVCAM-1), which correlated with the severity of the process. Also a significant decrease in concentrations TGF-β2 and IL-10 insevere preeclampsia was indicated, which may testify the exhaustion of adaptive mechanisms and, apparently, can be an additional diagnostic criterion for the prediction and assessment of the severity of the pathological process.
