The population genetic structure of the blacklegged tick Ixodes scapularis was analyzed using 853 individual ticks collected from 12 sites along the eastern seaboard of the United States. PCR-based DNA single strand ...The population genetic structure of the blacklegged tick Ixodes scapularis was analyzed using 853 individual ticks collected from 12 sites along the eastern seaboard of the United States. PCR-based DNA single strand conformation polymorphism(SSCP) was used for analysis of one haploid locus, the mitochondrial cytochrome b(Cyt b), and one diploid locus, the internal transcribed spacer 1(ITS1) of nuclear ribosomal RNA. Seven haplotypes in the Cyt b locus and 13 genotypes in the ITS1 locus were identified. Population differentiation and isolation by distance were found. Distribution of haplotype and genotype frequencies across geographic regions suggests that two distinct populations exist along the Eastern Coast of the US. However, genetic variation among individuals within regions was large. This degree of variation suggests frequent gene flow between regions. Moreover, overall genetic diversity among individuals was much higher in ticks from the southern population.展开更多
A Drinking Song Wine comes in at the mouth, And love comes in at the eue; That’s all we shall know for truth, Before we gorw old and die. I lift the glass to my mouth, I look at you,and I sigh.——W.B.Yeats(叶芝) Eve...A Drinking Song Wine comes in at the mouth, And love comes in at the eue; That’s all we shall know for truth, Before we gorw old and die. I lift the glass to my mouth, I look at you,and I sigh.——W.B.Yeats(叶芝) Everyone loves wine for different reasons,and everyone has a unique relationship to it.每个人喜爱葡萄酒的理由各不相同,而每个人与葡萄酒都有着别样的缘分。Show me a culture that doesn’t celebrate the good things in this short life by gathering together to eat and drink,and I’ll show you the on-off switches hidden behind their ears.展开更多
你猜FORD在研发第一代MUSTANG的同时,GM的Defense Research Labs(国防研究实验室)在干吗?那时,人类即将登月,确切说,是美国人即将登月。当他们踏上月球表面,他们需要运输工具,那里既没有地铁,也无法指望MUSTANG或是LAND ROVER,GM负责的...你猜FORD在研发第一代MUSTANG的同时,GM的Defense Research Labs(国防研究实验室)在干吗?那时,人类即将登月,确切说,是美国人即将登月。当他们踏上月球表面,他们需要运输工具,那里既没有地铁,也无法指望MUSTANG或是LAND ROVER,GM负责的正是月球车及其车轮的研发工作。展开更多
The macrophage migration inhibitory factor has been implicated in a number ofimmune and inflammatory processes. MIF presents particular opportunities for drug design anddevelopment with potential therapeutic applicati...The macrophage migration inhibitory factor has been implicated in a number ofimmune and inflammatory processes. MIF presents particular opportunities for drug design anddevelopment with potential therapeutic applications. Drug design strategies taking intoconsideration of specific stereochemical and tautomeric requirements in the interaction of MIF withsubstrates and inhibitors allow several novel structures to be designed. Our investigationssuccessfully explored the tautomeric and stereochemical aspects of new compounds of the2-phenylpyruvic acid type, both experimentally, through synthesis and structural investigations andcomputationally, through molecular mechanics and quantum mechanics calculations.展开更多
基金This research was supported by the Division of Ornithology and Panorama Society of The University of Kansas Natural History Museum and Biodiversity Research Center
文摘The population genetic structure of the blacklegged tick Ixodes scapularis was analyzed using 853 individual ticks collected from 12 sites along the eastern seaboard of the United States. PCR-based DNA single strand conformation polymorphism(SSCP) was used for analysis of one haploid locus, the mitochondrial cytochrome b(Cyt b), and one diploid locus, the internal transcribed spacer 1(ITS1) of nuclear ribosomal RNA. Seven haplotypes in the Cyt b locus and 13 genotypes in the ITS1 locus were identified. Population differentiation and isolation by distance were found. Distribution of haplotype and genotype frequencies across geographic regions suggests that two distinct populations exist along the Eastern Coast of the US. However, genetic variation among individuals within regions was large. This degree of variation suggests frequent gene flow between regions. Moreover, overall genetic diversity among individuals was much higher in ticks from the southern population.
文摘A Drinking Song Wine comes in at the mouth, And love comes in at the eue; That’s all we shall know for truth, Before we gorw old and die. I lift the glass to my mouth, I look at you,and I sigh.——W.B.Yeats(叶芝) Everyone loves wine for different reasons,and everyone has a unique relationship to it.每个人喜爱葡萄酒的理由各不相同,而每个人与葡萄酒都有着别样的缘分。Show me a culture that doesn’t celebrate the good things in this short life by gathering together to eat and drink,and I’ll show you the on-off switches hidden behind their ears.
文摘你猜FORD在研发第一代MUSTANG的同时,GM的Defense Research Labs(国防研究实验室)在干吗?那时,人类即将登月,确切说,是美国人即将登月。当他们踏上月球表面,他们需要运输工具,那里既没有地铁,也无法指望MUSTANG或是LAND ROVER,GM负责的正是月球车及其车轮的研发工作。
文摘The macrophage migration inhibitory factor has been implicated in a number ofimmune and inflammatory processes. MIF presents particular opportunities for drug design anddevelopment with potential therapeutic applications. Drug design strategies taking intoconsideration of specific stereochemical and tautomeric requirements in the interaction of MIF withsubstrates and inhibitors allow several novel structures to be designed. Our investigationssuccessfully explored the tautomeric and stereochemical aspects of new compounds of the2-phenylpyruvic acid type, both experimentally, through synthesis and structural investigations andcomputationally, through molecular mechanics and quantum mechanics calculations.
