Fatty acid composition of Sesamum indicum oil was determined by gas chromatography and the response of hypercholesterolemic rats to diet supplemented with Sesamum indicum seed oil was investigated. Twenty four rats we...Fatty acid composition of Sesamum indicum oil was determined by gas chromatography and the response of hypercholesterolemic rats to diet supplemented with Sesamum indicum seed oil was investigated. Twenty four rats weighing between 120-130 g were randomly assigned into four groups. Group A was fed normal diet, Group B, C and D were fed hypercholesterolemic diet （i.e. 20% fat ＋ 1% cholesterol） for two weeks to establish hypercholesterolemia. Group B were maintained on hyper diet while C and D were fed 5% and 10% benniseed oil supplemented diet for four weeks. Plasma was collected and analyzed for TC （total cholesterol）, HDL-C （high density lipoprotein）, LDL-C （low density lipoprotein） and TG （triglycerides） levels. Linoleic acid （42.44%） and oleic acid （40.60%） were the major unsaturated fatty acid in the oil. Significant increase （P 〈 0.05） was observed in the TC, TG, LDL and LDL/HDL ratio of the hypercholesterolemic rats compared to the normal control. Supplementation with Sesamum indicum seed oil at 5% and 10% levels resulted in significant decrease （P 〈 0.05） in TC, TG, LDL and LDL/HDL ratio, and significant increase in the HDL-C. The high level of unsaturated fatty acid in the oil may in part be responsible for the hypocholesterolemic effect of the oil.展开更多
文摘Fatty acid composition of Sesamum indicum oil was determined by gas chromatography and the response of hypercholesterolemic rats to diet supplemented with Sesamum indicum seed oil was investigated. Twenty four rats weighing between 120-130 g were randomly assigned into four groups. Group A was fed normal diet, Group B, C and D were fed hypercholesterolemic diet （i.e. 20% fat ＋ 1% cholesterol） for two weeks to establish hypercholesterolemia. Group B were maintained on hyper diet while C and D were fed 5% and 10% benniseed oil supplemented diet for four weeks. Plasma was collected and analyzed for TC （total cholesterol）, HDL-C （high density lipoprotein）, LDL-C （low density lipoprotein） and TG （triglycerides） levels. Linoleic acid （42.44%） and oleic acid （40.60%） were the major unsaturated fatty acid in the oil. Significant increase （P 〈 0.05） was observed in the TC, TG, LDL and LDL/HDL ratio of the hypercholesterolemic rats compared to the normal control. Supplementation with Sesamum indicum seed oil at 5% and 10% levels resulted in significant decrease （P 〈 0.05） in TC, TG, LDL and LDL/HDL ratio, and significant increase in the HDL-C. The high level of unsaturated fatty acid in the oil may in part be responsible for the hypocholesterolemic effect of the oil.
