Objective:To evaluate the effect of short term artemether administration on some blood parameters in adult male Wistar rats.Methods:Sixty five albino rats with body weight of 190-220 g were used for the four-phased st...Objective:To evaluate the effect of short term artemether administration on some blood parameters in adult male Wistar rats.Methods:Sixty five albino rats with body weight of 190-220 g were used for the four-phased study. The animals were randomly divided into five groups. The first-four groups of 15 rats were further divided into 3 subgroups of 5 rats. The drug was administered orally at sub-optimal, therapeutic, and high doses of 25, 50 and 75 mg/kg bw,respectively to the rats for 1 day, 2 days and 3 days. Blood samples were collected by cardio-puncture from the rats for hematology at the end of each phase. The last group served as control,and they were given waterad libitum.Results:Artemether caused significant reduction(P<0.05)of the hematological profile of the animals in a dose dependent manner. Discontinuation of the drug use however showed gradual recovery of the depressed indices of the blood parameters.Conclusions:The results suggest that artemether can induce reversible changes in hematological profiles of rats by extension man. This can probably aggravate anemia when artemether is administered to malaria patients. Hence, the study supports the use of the drug with cautione specially in patients prone to anemic tendencies.展开更多
Objective:To compare the pattern of jaundice resolution among children with severe malaria treated with quinine and artemether.Methods:Thirty two children who fulfilled the inclusion criteria were recruited for the st...Objective:To compare the pattern of jaundice resolution among children with severe malaria treated with quinine and artemether.Methods:Thirty two children who fulfilled the inclusion criteria were recruited for the study from two hospitals with intensive care facilities.They were divided into two groups:'Q' and 'A',receiving quinine and artemether.respectively.Jaundice was assessed by clinical examination.Results:Sixteen out of 32 children recruited(representing50%) presented with jaundice on the dav of recruitment.The mean age was(7.00±2.56) years.On day 3,tour patients in 'A' and six patients in 'O' had jaundice.By day 7.no child had jaundice.Conclusion:The study has shown that hoth drugs resolve jaundice although artemether relatively resolves it faster by the third day.展开更多
文摘Objective:To evaluate the effect of short term artemether administration on some blood parameters in adult male Wistar rats.Methods:Sixty five albino rats with body weight of 190-220 g were used for the four-phased study. The animals were randomly divided into five groups. The first-four groups of 15 rats were further divided into 3 subgroups of 5 rats. The drug was administered orally at sub-optimal, therapeutic, and high doses of 25, 50 and 75 mg/kg bw,respectively to the rats for 1 day, 2 days and 3 days. Blood samples were collected by cardio-puncture from the rats for hematology at the end of each phase. The last group served as control,and they were given waterad libitum.Results:Artemether caused significant reduction(P<0.05)of the hematological profile of the animals in a dose dependent manner. Discontinuation of the drug use however showed gradual recovery of the depressed indices of the blood parameters.Conclusions:The results suggest that artemether can induce reversible changes in hematological profiles of rats by extension man. This can probably aggravate anemia when artemether is administered to malaria patients. Hence, the study supports the use of the drug with cautione specially in patients prone to anemic tendencies.
基金sponsored by Overcomers Specialist Hospital,Ilisan Remo,Ogun State,Nigeria.Grant number:OML/RG/10/2
文摘Objective:To compare the pattern of jaundice resolution among children with severe malaria treated with quinine and artemether.Methods:Thirty two children who fulfilled the inclusion criteria were recruited for the study from two hospitals with intensive care facilities.They were divided into two groups:'Q' and 'A',receiving quinine and artemether.respectively.Jaundice was assessed by clinical examination.Results:Sixteen out of 32 children recruited(representing50%) presented with jaundice on the dav of recruitment.The mean age was(7.00±2.56) years.On day 3,tour patients in 'A' and six patients in 'O' had jaundice.By day 7.no child had jaundice.Conclusion:The study has shown that hoth drugs resolve jaundice although artemether relatively resolves it faster by the third day.
