The purpose of this study was to investigate age- specific spontaneous fetal loss rates of pregnancies without known chromosomal or structural abnormalities from mid- second trimester onward. The study consisted of 26...The purpose of this study was to investigate age- specific spontaneous fetal loss rates of pregnancies without known chromosomal or structural abnormalities from mid- second trimester onward. The study consisted of 264,653 women screened between October 1995 and September 2000 with available pregnancy outcomes. Pregnancies associated with fetal chromosomal or structural abnormalities, insulin dependent diabetes mellitus, and multiple pregnancies were excluded. Spontaneous fetal losses at or after 15 weeks of gestation were identified. Women were grouped according to maternal age at expected date of delivery. Spontaneous fetal loss rates in each group were evaluated after adjusting fetal losses associated with amniocentesis and identifiable ethnic groups. Fetal loss rates increased in both younger and older women. The lowest rate was seen in women at mid- 20s. Compared with Caucasian and Asian women, black women had higher fetal loss rate at nearly every age group. The results of the study provided a baseline agespecific spontaneous fetal loss rate of pregnancies at a specified gestational window.展开更多
Objective: The purpose of this study was to investigate associations between risk of spontaneous fetal loss and risk estimates for Down syndrome, trisomy 18, and neural tube defects assigned by second-trimester matern...Objective: The purpose of this study was to investigate associations between risk of spontaneous fetal loss and risk estimates for Down syndrome, trisomy 18, and neural tube defects assigned by second-trimester maternal serum screening. Study design: The study involved 264,653 women with available pregnancy outcomes who were screened between 15 and 20 weeks of gestation in the Ontario Maternal Serum Screening Program between October 1995 and September 2000. Pregnancies complicated by fetal chromosomal or structural abnormalities, insulin-dependent diabetes mellitus, and multiple pregnancies were excluded. Spontaneous fetal loss was defined as spontaneous miscarriage and intrauterine fetal demise as classified by the ICD- 9 system, but including only those ≥ 15 weeks of gestation. Women were grouped according to risk estimates for Down syndrome, trisomy 18, and neural tube defects, respectively. Spontaneous fetal loss rates by each risk group were evaluated after adjusting for losses associated with maternal age and amniocentesis. Results: Fetal loss rates increased in women with risk estimates of ≥ 1 in 1110 for trisomy 18 or neural tube defects, and ≥ 1 in 130 for Down syndrome. The excessive fetal loss rates for these 3 groups of women were 14.4% , 3.2% , and 1.5% respectively. Conclusion: Fetal loss rate markedly increased in women with high-risk estimates for trisomy 18, neural tube defects, and Down syndrome. Risk estimates assigned by triple marker screening may provide an early means of stratifying pregnancies into risk for fetal loss.展开更多
文摘The purpose of this study was to investigate age- specific spontaneous fetal loss rates of pregnancies without known chromosomal or structural abnormalities from mid- second trimester onward. The study consisted of 264,653 women screened between October 1995 and September 2000 with available pregnancy outcomes. Pregnancies associated with fetal chromosomal or structural abnormalities, insulin dependent diabetes mellitus, and multiple pregnancies were excluded. Spontaneous fetal losses at or after 15 weeks of gestation were identified. Women were grouped according to maternal age at expected date of delivery. Spontaneous fetal loss rates in each group were evaluated after adjusting fetal losses associated with amniocentesis and identifiable ethnic groups. Fetal loss rates increased in both younger and older women. The lowest rate was seen in women at mid- 20s. Compared with Caucasian and Asian women, black women had higher fetal loss rate at nearly every age group. The results of the study provided a baseline agespecific spontaneous fetal loss rate of pregnancies at a specified gestational window.
文摘Objective: The purpose of this study was to investigate associations between risk of spontaneous fetal loss and risk estimates for Down syndrome, trisomy 18, and neural tube defects assigned by second-trimester maternal serum screening. Study design: The study involved 264,653 women with available pregnancy outcomes who were screened between 15 and 20 weeks of gestation in the Ontario Maternal Serum Screening Program between October 1995 and September 2000. Pregnancies complicated by fetal chromosomal or structural abnormalities, insulin-dependent diabetes mellitus, and multiple pregnancies were excluded. Spontaneous fetal loss was defined as spontaneous miscarriage and intrauterine fetal demise as classified by the ICD- 9 system, but including only those ≥ 15 weeks of gestation. Women were grouped according to risk estimates for Down syndrome, trisomy 18, and neural tube defects, respectively. Spontaneous fetal loss rates by each risk group were evaluated after adjusting for losses associated with maternal age and amniocentesis. Results: Fetal loss rates increased in women with risk estimates of ≥ 1 in 1110 for trisomy 18 or neural tube defects, and ≥ 1 in 130 for Down syndrome. The excessive fetal loss rates for these 3 groups of women were 14.4% , 3.2% , and 1.5% respectively. Conclusion: Fetal loss rate markedly increased in women with high-risk estimates for trisomy 18, neural tube defects, and Down syndrome. Risk estimates assigned by triple marker screening may provide an early means of stratifying pregnancies into risk for fetal loss.
