The title compound, C9H9N5OS, was synthesized by the reaction of 3-(1H)-1,2,4 -triazole hydrazine with 3-methyl-2-thiophenecarboxaldehyde in ethanol. The single crystal structure has been determined by X-ray diffrac...The title compound, C9H9N5OS, was synthesized by the reaction of 3-(1H)-1,2,4 -triazole hydrazine with 3-methyl-2-thiophenecarboxaldehyde in ethanol. The single crystal structure has been determined by X-ray diffraction analysis. The crystal belongs to monoclinic system, space group P2 1/n with a = 9.5550(10), b = 11.9847(12), c = 10.1074(11) A,β= 112.995(2)° V= 1065.47(19) A^3, Z = 4,μ = 0.290 mm^-1, Mr= 235.27, Dc = 1.467 g/cm^3 and F(000) = 488. The structure was solved by direct methods and refined to R = 0.0449. The crystal structure involves intermolecular hydrogen bonds of N-H…O and N-H…N as well as intramolecular hydrogen bond of N-H…N. Its biological activity has also been determined showing this type of compounds has certain antibacterial activity.展开更多
The title compound C15H12N4O2S was synthesized by the reaction of 3-(2-hydroxybenzyl)-4-amino-(1H)-1,2,4-triazole-5-thione with 4-hydroxybenzaldehyde in ethanol and characterized by IR, ^1H NMR spectra and element...The title compound C15H12N4O2S was synthesized by the reaction of 3-(2-hydroxybenzyl)-4-amino-(1H)-1,2,4-triazole-5-thione with 4-hydroxybenzaldehyde in ethanol and characterized by IR, ^1H NMR spectra and elemental analysis. Its structure has been determined by X-ray diffraction analysis. The crystal belongs to monoclinic, space group C2/c with a = 27.990(3), b = 13.1326(14), c = 7.9770(8) A, β= 105.787(2)°, V = 2821.6(5)A^3, Z = 8, Mr= 312.35,μ= 0.243 mm^-1, Dc = 1.471 g/cm^3 and F(000) = 1296. The structure was solved by direct methods.and refined to a Rint value of 0.0388. The crystal structure involving in intermolecular N-H…S and O-H…S hydrogen bonds is observed, meanwhile intramolecular O-H…N hydrogen bond is also found. Their biological activities have been measured. The results show that this type of compound has certain antibacterial activity for Staphylococous aureus and Bacillus subtilis.展开更多
The title compound C18H22N4O4 was synthesized by the reaction of 3-hydrazine-4-hydroxy-6-methyl-2(1H)-pyridinones with 2-hydroxy-4-diethylaminobenzaldehyde in ethanol and characteri- zed by IR, tH NMR and elemental ...The title compound C18H22N4O4 was synthesized by the reaction of 3-hydrazine-4-hydroxy-6-methyl-2(1H)-pyridinones with 2-hydroxy-4-diethylaminobenzaldehyde in ethanol and characteri- zed by IR, tH NMR and elemental analysis. The single-crystal structure has been determined by X-ray diffraction analysis. The crystal belongs to the triclinic system, space group P1^- with a = 10.1930(14), b = 12.5200(17), c = 15.1863(19) A, α= 96.292(3), β= 96.450(3), γ= 102.443(3)°, V= 1862.6(4) A^3, Z= 4, Mr = 358.40, μ = 0.092 mm^-1, D c= 1.278 g/cm^3, F(000) = 760 and R = 0.0803. The crystal structure involves intermolcular N-H…O as well as intramolcular O-H…N, O-H…O and N-H…O hydrogen bonds. The title compound shows no antibacterial activity.展开更多
In the ethanol solvent, a nickel(Ⅱ) complex Ni(C12H10N2O2S)2 upon reaction of 2'-(2-thienylidene)-hydroxybenzoylhydrazide with nickel acetate was synthesized, and its structure was characterized by IR, UV, ele...In the ethanol solvent, a nickel(Ⅱ) complex Ni(C12H10N2O2S)2 upon reaction of 2'-(2-thienylidene)-hydroxybenzoylhydrazide with nickel acetate was synthesized, and its structure was characterized by IR, UV, elemental analysis and X-ray diffraction analysis. The crystal belongs to monoclinic system, space group C2/c with a = 22.052(3), b = 5.9681(6), c = 18.522(2)A , β = 110.679(4)°, V = 2280.6(4)A^3, Z = 4, Mr = 551.27, μ = 1.606 mm^-1, Dc = 1.075 g/cm^3, F(000) = 1136 and Rint = 0.0556. The nickel(Ⅱ ) atom in the compound is four-coordinated with two nitrogen atoms from amide and two oxygen atoms from keto group. The biological activities have been measured, show- ing the compound exhibits better anti-bacterial activity than the ligand.展开更多
基金This work was supported by the Natural Science Foundation of Zhejiang Province (No. M203115) and Scientific Research Fund of Zhejiang Provincial Education Department(NO.20050057)
文摘The title compound, C9H9N5OS, was synthesized by the reaction of 3-(1H)-1,2,4 -triazole hydrazine with 3-methyl-2-thiophenecarboxaldehyde in ethanol. The single crystal structure has been determined by X-ray diffraction analysis. The crystal belongs to monoclinic system, space group P2 1/n with a = 9.5550(10), b = 11.9847(12), c = 10.1074(11) A,β= 112.995(2)° V= 1065.47(19) A^3, Z = 4,μ = 0.290 mm^-1, Mr= 235.27, Dc = 1.467 g/cm^3 and F(000) = 488. The structure was solved by direct methods and refined to R = 0.0449. The crystal structure involves intermolecular hydrogen bonds of N-H…O and N-H…N as well as intramolecular hydrogen bond of N-H…N. Its biological activity has also been determined showing this type of compounds has certain antibacterial activity.
基金This work was supported by the Natural Science Foundation of Zhejiang Province (No. M203115) and Scientific Research Fund of Zhejiang Provincial Education Department (NO. 20050057)
文摘The title compound C15H12N4O2S was synthesized by the reaction of 3-(2-hydroxybenzyl)-4-amino-(1H)-1,2,4-triazole-5-thione with 4-hydroxybenzaldehyde in ethanol and characterized by IR, ^1H NMR spectra and elemental analysis. Its structure has been determined by X-ray diffraction analysis. The crystal belongs to monoclinic, space group C2/c with a = 27.990(3), b = 13.1326(14), c = 7.9770(8) A, β= 105.787(2)°, V = 2821.6(5)A^3, Z = 8, Mr= 312.35,μ= 0.243 mm^-1, Dc = 1.471 g/cm^3 and F(000) = 1296. The structure was solved by direct methods.and refined to a Rint value of 0.0388. The crystal structure involving in intermolecular N-H…S and O-H…S hydrogen bonds is observed, meanwhile intramolecular O-H…N hydrogen bond is also found. Their biological activities have been measured. The results show that this type of compound has certain antibacterial activity for Staphylococous aureus and Bacillus subtilis.
基金This work was supported by the Natural Science Foundation of Zhejiang Province (No. M203115) and Scientific Research Fund of Zhejiang Provincial Education Department (No. 20050057, 20050051)
文摘The title compound C18H22N4O4 was synthesized by the reaction of 3-hydrazine-4-hydroxy-6-methyl-2(1H)-pyridinones with 2-hydroxy-4-diethylaminobenzaldehyde in ethanol and characteri- zed by IR, tH NMR and elemental analysis. The single-crystal structure has been determined by X-ray diffraction analysis. The crystal belongs to the triclinic system, space group P1^- with a = 10.1930(14), b = 12.5200(17), c = 15.1863(19) A, α= 96.292(3), β= 96.450(3), γ= 102.443(3)°, V= 1862.6(4) A^3, Z= 4, Mr = 358.40, μ = 0.092 mm^-1, D c= 1.278 g/cm^3, F(000) = 760 and R = 0.0803. The crystal structure involves intermolcular N-H…O as well as intramolcular O-H…N, O-H…O and N-H…O hydrogen bonds. The title compound shows no antibacterial activity.
基金Supported by the Natural Science Foundation of Zhejiang Province (No. Y406049)Scientific Research Fund of Zhejiang Provincial Education Department (No. 20060079)
文摘In the ethanol solvent, a nickel(Ⅱ) complex Ni(C12H10N2O2S)2 upon reaction of 2'-(2-thienylidene)-hydroxybenzoylhydrazide with nickel acetate was synthesized, and its structure was characterized by IR, UV, elemental analysis and X-ray diffraction analysis. The crystal belongs to monoclinic system, space group C2/c with a = 22.052(3), b = 5.9681(6), c = 18.522(2)A , β = 110.679(4)°, V = 2280.6(4)A^3, Z = 4, Mr = 551.27, μ = 1.606 mm^-1, Dc = 1.075 g/cm^3, F(000) = 1136 and Rint = 0.0556. The nickel(Ⅱ ) atom in the compound is four-coordinated with two nitrogen atoms from amide and two oxygen atoms from keto group. The biological activities have been measured, show- ing the compound exhibits better anti-bacterial activity than the ligand.