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α7烟碱型乙酰胆碱受体在肺癌中作用的研究进展
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作者 潘汉博 罗清泉 《中国胸心血管外科临床杂志》 CSCD 北大核心 2023年第6期917-923,共7页
肺癌是全球发病率和死亡率最高的恶性肿瘤之一。吸烟是肺癌最主要的危险因素,尼古丁是烟草烟雾中危害最大的成分之一。烟碱型乙酰胆碱受体(nicotinic acetylcholine receptors,nAChRs)在哺乳动物体细胞和癌细胞中均广泛存在,并执行多种... 肺癌是全球发病率和死亡率最高的恶性肿瘤之一。吸烟是肺癌最主要的危险因素,尼古丁是烟草烟雾中危害最大的成分之一。烟碱型乙酰胆碱受体(nicotinic acetylcholine receptors,nAChRs)在哺乳动物体细胞和癌细胞中均广泛存在,并执行多种重要功能。α7nAChR是nAChRs家族重要成员,与尼古丁具有高亲和力,在尼古丁诱导的肺癌细胞增殖、血管生成、侵袭和远处转移过程中起关键作用。目前,许多α7nAChR抑制剂已在体外和体内研究中显示出抑制肺癌细胞增殖、侵袭和血管生成从而对抗疾病进展的良好效果,提示α7nAChR可能成为肺癌潜在治疗靶点。本文对α7nAChR在肺癌进展中作用的研究进展进行综述。 展开更多
关键词 肺癌 Α7烟碱型乙酰胆碱受体 尼古丁 综述
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A Review of Advances in Lightning Observations during the Past Decade in Guangdong, China 被引量:8
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作者 ZHANG Yijun LU Weitao +7 位作者 CHEN Shaodong ZHENG Dong ZHANG Yang YAN Xu CHEN Liiwen DONG Wansheng DAN Jianru pan hanbo 《Journal of Meteorological Research》 SCIE CSCD 2016年第5期800-819,共20页
This paper reviews recent advances in understanding the physical processes of artificially triggered light- ning and natural lightning as well as the progress in testing lightning protection technologies, based on a s... This paper reviews recent advances in understanding the physical processes of artificially triggered light- ning and natural lightning as well as the progress in testing lightning protection technologies, based on a series of lightning field campaigns jointly conducted by the Chinese Academy of Meteorological Sciences and Guangdong Meteorological Bureau since 2006. During the decade-long series of lightning field experi- ments, the technology of rocket-wire artificially triggered lightning has been improved, and has successfully triggered 94 lightning flashes. Through direct lightning current waveform measurements, an average return stroke peak current of 16 kA was obtained. The phenomenon that the downward leader connects to the lateral surface of the upward leader in the attachment process was discovered, and the speed of the upward leader during the connection process being significantly greater than that of the downward leader was re- vealed. The characteristics of several return strokes in cloud-to-ground lighting have also been unveiled, and the mechanism causing damage to lightning protection devices (i.e., ground potential rise within the rated current) was established. The performance of three lightning monitoring systems in Guangdong Province has also been quantitatively assessed. 展开更多
关键词 LIGHTNING field observation experiment artificially triggered lightning lightning physical pro- cesses lightning protection
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