What prompted you to go to Lesotho？ In July 2011, I got a call from the cultural authority of Foshan City in south China＇s Guangdong Province. They invited me and another artist, along with an interpreter, to go to ...What prompted you to go to Lesotho？ In July 2011, I got a call from the cultural authority of Foshan City in south China＇s Guangdong Province. They invited me and another artist, along with an interpreter, to go to Maseru, the capital of Lesotho, for two months to teach local people how to make展开更多
Mucopolysaccharidosis type II is of high ge-netic heterogeneity. PCR-DNA sequencing was used to study the mutation hot spots in the IDS gene of a Chinese MPS II pedigree. A new mutation (1467-A) not yet reported world...Mucopolysaccharidosis type II is of high ge-netic heterogeneity. PCR-DNA sequencing was used to study the mutation hot spots in the IDS gene of a Chinese MPS II pedigree. A new mutation (1467-A) not yet reported world-wide was detected. This mutation located at 448th codon in the coding region of exon 9 deletes one “A” at the end of 1467 bp (cDNA). The frame-shift mutation makes the peptide chain shorten from amino acids 550 to 459, probably altering the configuration of IDS enzyme protein remarkably and lowering the activation of IDS greatly. Therefore it is sup-posed to be the direct cause of the patient with MPS II and to be a necessary premise for prenatal gene diagnosis.展开更多
文摘What prompted you to go to Lesotho？ In July 2011, I got a call from the cultural authority of Foshan City in south China＇s Guangdong Province. They invited me and another artist, along with an interpreter, to go to Maseru, the capital of Lesotho, for two months to teach local people how to make
文摘Mucopolysaccharidosis type II is of high ge-netic heterogeneity. PCR-DNA sequencing was used to study the mutation hot spots in the IDS gene of a Chinese MPS II pedigree. A new mutation (1467-A) not yet reported world-wide was detected. This mutation located at 448th codon in the coding region of exon 9 deletes one “A” at the end of 1467 bp (cDNA). The frame-shift mutation makes the peptide chain shorten from amino acids 550 to 459, probably altering the configuration of IDS enzyme protein remarkably and lowering the activation of IDS greatly. Therefore it is sup-posed to be the direct cause of the patient with MPS II and to be a necessary premise for prenatal gene diagnosis.
