目的探讨白细胞介素21(Interleukin-21,IL-21)参与e抗原(hepatitis B e antigen,HBeAg)阳性慢性乙型肝炎(chronic hepatistis B,CHB)免疫病程的进展。方法入组2022年1月—2023年1月间由常州市金坛第一人民医院、镇江市第三人民医院诊治...目的探讨白细胞介素21(Interleukin-21,IL-21)参与e抗原(hepatitis B e antigen,HBeAg)阳性慢性乙型肝炎(chronic hepatistis B,CHB)免疫病程的进展。方法入组2022年1月—2023年1月间由常州市金坛第一人民医院、镇江市第三人民医院诊治的HBeAg阳性CHB患者45例、CHB患者免疫耐受状态(immune tolerant,IT)20例、非活动表面抗原(hepatitis B s antigen,HBsAg)携带者(inactive carrier,IC)45例,在抗病毒治疗前及治疗48周后分别检测HBV血清标志物(HBeAg、HBsAg、Anti-HBs、Anti-HBe、Anti-HBc)、ALT、HBV DNA载量、IL-21浓度、IL-21^(+)CD4^(+)T细胞、IL-21R^(+)CD4^(+)T细胞频数。同时选取15例健康体检者检测相同指标作为对照。结果CHB和IC组患者的血清IL-21浓度[分别为(82.21±22.32)、(72.32±25.26)pg/mL]均显著高于HBeAg阳性免疫耐受患者[(20.24±15.56)pg/mL,P值均<0.001],IC组患者的IL-21^(+)CD4^(+)T细胞频数为(7.42±2.34)%、IL-21R^(+)CD4^(+)T细胞频数为(6.46±1.55)%,均显著高于CHB组(P值均<0.001)。血清ALT与IL-21浓度无相关性(r=0.136,P=0.20)。HBeAg阳性CHB患者抗病毒治疗后达到HBeAg血清学转换组治疗前外周血IL-21浓度为(92.58±25.76)pg/mL、IL-21^(+)CD4^(+)T细胞频数为(7.89±2.05)%、IL-21R^(+)CD4^(+)T细胞频数(7.01±1.51)%,均显著高于未达到HBeAg血清学转换组(P值均<0.01)。结论IL-21参与了HBeAg阳性CHB免疫病程的进展。展开更多
Digital technology has driven the innovation of architectural design methods and tools,applying digital techniques to allow greater possibilities for more innovative and scientific design of public building spaces.Thi...Digital technology has driven the innovation of architectural design methods and tools,applying digital techniques to allow greater possibilities for more innovative and scientific design of public building spaces.This article first analyzes the characteristics of digital visualization and its advantages in the design of urban public building spaces,including aspects such as visualizing three-dimensional expression,rational analysis of building space,Virtual Reality Experience,and integration of design and construction processes.Subsequently,by introducing digital design methods such as parametric design,algorithmic generation,nonlinear design,and artificial intelligence-assisted design,it explores the methods and implementation approaches of digital visualization in the design of public building spaces.The aim is to offer insights and references for the deeper integration of digital technology into architectural design practices.展开更多
Urban public building spaces involve various aspects of people’s daily activities and interactions,making the rationality and scientific nature of the design of these spaces crucial.This article first discusses the r...Urban public building spaces involve various aspects of people’s daily activities and interactions,making the rationality and scientific nature of the design of these spaces crucial.This article first discusses the role and impact of digitization in the design of public building spaces,covering aspects such as digital design methods,visual expression and presentation,augmented reality’s spatial interaction experience,and integrated design and construction.Following that,it analyzes the process of digitized urban public building space design by exploring topics like digital space design and modeling,visual representation of digital spaces,digital performance analysis of spaces,and the integration of digital projects.This article aims to provide insights and references for urban public building space design in the digital era.展开更多
With the development and innovation of digital information technology, digital visualization plays an increasingly important role in the design of urban public building spaces. This paper explores the application of d...With the development and innovation of digital information technology, digital visualization plays an increasingly important role in the design of urban public building spaces. This paper explores the application of digital visualization technology in the design of urban public building spaces and looks ahead to future trends. Firstly, it analyzes the challenges in the design of urban public building spaces, including extensive professional involvement, complex functional layout requirements, rational emergency evacuation routes, multidimensional analysis of architectural spatial environments, and appropriate selection of decorative materials. Next, it introduces the applications of digital visualization technology in showcasing visual design and expression, optimizing spatial functional layouts, enhancing the rationality of evacuation routes, analyzing dynamic environmental impacts and energy consumption, and improving the effectiveness of material selection in the design of urban public building spaces. Lastly, it discusses the prospects of extended reality (XR) technology, interactive design using data platforms, and AI technology in the design of public building spaces. It is hoped that this paper provides inspiration and reference for the deeper application of digital information technology in the field of architecture. .展开更多
在工厂化循环水养殖中,准确识别鱼类摄食强度是实现精准投喂的前提和关键。水质、视觉、声音等单模态数据均可用于评估摄食强度,但单一模态往往具有片面性,难以完全反映全局特征,存在识别精度低、可移植性差等问题。多模态方法通过融合...在工厂化循环水养殖中,准确识别鱼类摄食强度是实现精准投喂的前提和关键。水质、视觉、声音等单模态数据均可用于评估摄食强度,但单一模态往往具有片面性,难以完全反映全局特征,存在识别精度低、可移植性差等问题。多模态方法通过融合不同模态的特征,可为摄食强度量化提供新的手段。基于此,为融合鱼类摄食中的“水质-声音-视觉”信息,实现高精度的鱼类摄食强度量化,该研究在多模态Transformer(multimodal transformer,MulT)的基础上,提出一种多模态融合的鱼类摄食强度识别算法Fish-MulT。首先,从输入的水质、声音和视觉数据中提取特征向量;其次,利用多模态转移模块(multimodal transfer module,MMTM)对输入的特征向量进行融合,得到3种融合向量;然后对融合向量添加自适应权重并相加,得到融合模态;最后,利用融合模态将MulT算法中各模态分支的跨模态Transformer(cross-modal transformer)从2个优化为1个。试验结果表明,与MulT算法相比,该研究算法的鱼类摄食强度识别准确率由93.30%提高到95.36%,参数量减少38%。与水质、声音和视觉单模态相比,准确率分别提高68.56、21.65和3.61个百分点。可用于制定精准投喂策略,并为开发智能投喂系统提供技术支持。展开更多
文摘目的探讨白细胞介素21(Interleukin-21,IL-21)参与e抗原(hepatitis B e antigen,HBeAg)阳性慢性乙型肝炎(chronic hepatistis B,CHB)免疫病程的进展。方法入组2022年1月—2023年1月间由常州市金坛第一人民医院、镇江市第三人民医院诊治的HBeAg阳性CHB患者45例、CHB患者免疫耐受状态(immune tolerant,IT)20例、非活动表面抗原(hepatitis B s antigen,HBsAg)携带者(inactive carrier,IC)45例,在抗病毒治疗前及治疗48周后分别检测HBV血清标志物(HBeAg、HBsAg、Anti-HBs、Anti-HBe、Anti-HBc)、ALT、HBV DNA载量、IL-21浓度、IL-21^(+)CD4^(+)T细胞、IL-21R^(+)CD4^(+)T细胞频数。同时选取15例健康体检者检测相同指标作为对照。结果CHB和IC组患者的血清IL-21浓度[分别为(82.21±22.32)、(72.32±25.26)pg/mL]均显著高于HBeAg阳性免疫耐受患者[(20.24±15.56)pg/mL,P值均<0.001],IC组患者的IL-21^(+)CD4^(+)T细胞频数为(7.42±2.34)%、IL-21R^(+)CD4^(+)T细胞频数为(6.46±1.55)%,均显著高于CHB组(P值均<0.001)。血清ALT与IL-21浓度无相关性(r=0.136,P=0.20)。HBeAg阳性CHB患者抗病毒治疗后达到HBeAg血清学转换组治疗前外周血IL-21浓度为(92.58±25.76)pg/mL、IL-21^(+)CD4^(+)T细胞频数为(7.89±2.05)%、IL-21R^(+)CD4^(+)T细胞频数(7.01±1.51)%,均显著高于未达到HBeAg血清学转换组(P值均<0.01)。结论IL-21参与了HBeAg阳性CHB免疫病程的进展。
文摘Digital technology has driven the innovation of architectural design methods and tools,applying digital techniques to allow greater possibilities for more innovative and scientific design of public building spaces.This article first analyzes the characteristics of digital visualization and its advantages in the design of urban public building spaces,including aspects such as visualizing three-dimensional expression,rational analysis of building space,Virtual Reality Experience,and integration of design and construction processes.Subsequently,by introducing digital design methods such as parametric design,algorithmic generation,nonlinear design,and artificial intelligence-assisted design,it explores the methods and implementation approaches of digital visualization in the design of public building spaces.The aim is to offer insights and references for the deeper integration of digital technology into architectural design practices.
文摘Urban public building spaces involve various aspects of people’s daily activities and interactions,making the rationality and scientific nature of the design of these spaces crucial.This article first discusses the role and impact of digitization in the design of public building spaces,covering aspects such as digital design methods,visual expression and presentation,augmented reality’s spatial interaction experience,and integrated design and construction.Following that,it analyzes the process of digitized urban public building space design by exploring topics like digital space design and modeling,visual representation of digital spaces,digital performance analysis of spaces,and the integration of digital projects.This article aims to provide insights and references for urban public building space design in the digital era.
文摘With the development and innovation of digital information technology, digital visualization plays an increasingly important role in the design of urban public building spaces. This paper explores the application of digital visualization technology in the design of urban public building spaces and looks ahead to future trends. Firstly, it analyzes the challenges in the design of urban public building spaces, including extensive professional involvement, complex functional layout requirements, rational emergency evacuation routes, multidimensional analysis of architectural spatial environments, and appropriate selection of decorative materials. Next, it introduces the applications of digital visualization technology in showcasing visual design and expression, optimizing spatial functional layouts, enhancing the rationality of evacuation routes, analyzing dynamic environmental impacts and energy consumption, and improving the effectiveness of material selection in the design of urban public building spaces. Lastly, it discusses the prospects of extended reality (XR) technology, interactive design using data platforms, and AI technology in the design of public building spaces. It is hoped that this paper provides inspiration and reference for the deeper application of digital information technology in the field of architecture. .
文摘在工厂化循环水养殖中,准确识别鱼类摄食强度是实现精准投喂的前提和关键。水质、视觉、声音等单模态数据均可用于评估摄食强度,但单一模态往往具有片面性,难以完全反映全局特征,存在识别精度低、可移植性差等问题。多模态方法通过融合不同模态的特征,可为摄食强度量化提供新的手段。基于此,为融合鱼类摄食中的“水质-声音-视觉”信息,实现高精度的鱼类摄食强度量化,该研究在多模态Transformer(multimodal transformer,MulT)的基础上,提出一种多模态融合的鱼类摄食强度识别算法Fish-MulT。首先,从输入的水质、声音和视觉数据中提取特征向量;其次,利用多模态转移模块(multimodal transfer module,MMTM)对输入的特征向量进行融合,得到3种融合向量;然后对融合向量添加自适应权重并相加,得到融合模态;最后,利用融合模态将MulT算法中各模态分支的跨模态Transformer(cross-modal transformer)从2个优化为1个。试验结果表明,与MulT算法相比,该研究算法的鱼类摄食强度识别准确率由93.30%提高到95.36%,参数量减少38%。与水质、声音和视觉单模态相比,准确率分别提高68.56、21.65和3.61个百分点。可用于制定精准投喂策略,并为开发智能投喂系统提供技术支持。
