Hydrogel stands out as one of the most attractive wound dressings due to its excellent moisturizing properties and capacity to absorb wound exudates.However,conventional hydrogel dressings often lack responsiveness to...Hydrogel stands out as one of the most attractive wound dressings due to its excellent moisturizing properties and capacity to absorb wound exudates.However,conventional hydrogel dressings often lack responsiveness to the microenvironment,merely acting as protective barriers for the wound.Consequently,they exhibit limited effectiveness in preventing infection and facilitating wound repair.To address these problems,we have developed a multifunctional injectable hydrogel,CF/MS@HG,based on peroxidase-like nanozymes,aiming at rapidly healing bacterial-infected wounds.The hydrogel is mainly composed of oxidized sodium alginate,aminated gelatin,and polylysine,encapsulating MIL-101(CuFe)NPs(CF)and manganese selenide nanoparticles(MnSe_(2) NPs,or MS NPs).After injection,the complex rapidly gelatinizes at the infected wound site through a Schiff base reaction.In vitro experiments have demonstrated the hydrogel’s strong adhesion and self-healing capabilities.Moreover,CF exhibiting peroxidase(POD)-like activity,catalyzes in situ hydrogen peroxide(H_(2)O_(2))to generate highly toxic hydroxyl radicals(·OH)within the wound microenvironment,inducing oxidative damage to bacteria.Meanwhile,MS decomposes into H2Se in the slightly acidic wound microenvironment,disrupting bacterial metabolism and inhibiting proliferation.The addition of polylysine further enhances the hydrogel’s antibacterial properties.In vivo experiments have shown that the hydrogel exhibits excellent biological safety and significantly promotes wound healing.This multifunctional smart hydrogel holds great promise for the treatment of bacterial-infected wounds.展开更多
目的系统评价透明质酸钠联合A型肉毒毒素治疗面部皱纹的有效性和安全性。方法检索Embase、PubMed、Web of Science、中国知网和万方等数据库,检索时间为建库至2022年4月8日。根据纳入标准及排除标准筛选文献,参考Cochrane手册和NOS量表...目的系统评价透明质酸钠联合A型肉毒毒素治疗面部皱纹的有效性和安全性。方法检索Embase、PubMed、Web of Science、中国知网和万方等数据库,检索时间为建库至2022年4月8日。根据纳入标准及排除标准筛选文献,参考Cochrane手册和NOS量表进行文献质量评价,采用Revman 5.4软件对纳入的文献进行Meta分析。结果本研究共纳入17篇文献,包含随机临床对照试验篇和回顾性研究,共计2284例患者,治疗组(A型肉毒素注射联合透明质酸钠)1142例,对照组(单独注射A型肉毒毒素)1142例。Meta分析结果:治疗组的有效率、维持时间、患者满意度均优于对照组,差异有统计学意义(P<0.05)。治疗组患者的不良反应、复发情况均少于对照组,差异有统计学意义(P<0.05)。结论透明质酸钠联合A型肉毒毒素在治疗面部皱纹方面具有一定的优势,但由于受纳入研究的数量和质量限制,针对面部不同皱纹,二者联合使用时,如何配比能够获得更好的疗效值得继续被探索。展开更多
目的对封闭式负压引流技术联合高压氧治疗慢性难愈性创面的临床疗效和安全性进行系统评价。方法检索Embase、Pub Med、Cochrane Library、Web of Science、中国知网(CNKI)和万方数据库等数据库,检索时间为建库至2020年12月28日。根据纳...目的对封闭式负压引流技术联合高压氧治疗慢性难愈性创面的临床疗效和安全性进行系统评价。方法检索Embase、Pub Med、Cochrane Library、Web of Science、中国知网(CNKI)和万方数据库等数据库,检索时间为建库至2020年12月28日。根据纳入标准及排除标准筛选文献,参考Cochrane手册和NOS量表进行文献质量评价,使用R语言Meta数据包对纳入的文献进行Meta分析。结果共纳入10篇文献,其中包含随机临床对照试验5篇和回顾性研究5篇,共计591例患者,其中治疗组294例,对照组297例。Meta分析结果:治疗组(封闭式负压引流联合高压氧)在创面愈合率、创面愈合时间、创面面积等方面均优于对照组(封闭式负压引流),差异有统计学意义(P<0.05)。结论封闭式负压引流联合高压氧较单纯负压引流治疗,在难愈性创面治疗方面具有较高的优势,但该结论还需要较大样本和更高质量的随机临床对照试验进一步验证。展开更多
基金supported by the National Natural Science Foundation of China(Grant No.52102353)the Natural Science Foundation of Zhejiang Province(Grant No.LQ22E030018)+1 种基金the Fundamental Research Funds of Tongxiang Research Institute of Zhejiang Sci-Tech University(Grant No.TYY202212)the Key Research&Development Program of Zhejiang Province(Grant Nos.2021C01180 and 2019C04020).
文摘Hydrogel stands out as one of the most attractive wound dressings due to its excellent moisturizing properties and capacity to absorb wound exudates.However,conventional hydrogel dressings often lack responsiveness to the microenvironment,merely acting as protective barriers for the wound.Consequently,they exhibit limited effectiveness in preventing infection and facilitating wound repair.To address these problems,we have developed a multifunctional injectable hydrogel,CF/MS@HG,based on peroxidase-like nanozymes,aiming at rapidly healing bacterial-infected wounds.The hydrogel is mainly composed of oxidized sodium alginate,aminated gelatin,and polylysine,encapsulating MIL-101(CuFe)NPs(CF)and manganese selenide nanoparticles(MnSe_(2) NPs,or MS NPs).After injection,the complex rapidly gelatinizes at the infected wound site through a Schiff base reaction.In vitro experiments have demonstrated the hydrogel’s strong adhesion and self-healing capabilities.Moreover,CF exhibiting peroxidase(POD)-like activity,catalyzes in situ hydrogen peroxide(H_(2)O_(2))to generate highly toxic hydroxyl radicals(·OH)within the wound microenvironment,inducing oxidative damage to bacteria.Meanwhile,MS decomposes into H2Se in the slightly acidic wound microenvironment,disrupting bacterial metabolism and inhibiting proliferation.The addition of polylysine further enhances the hydrogel’s antibacterial properties.In vivo experiments have shown that the hydrogel exhibits excellent biological safety and significantly promotes wound healing.This multifunctional smart hydrogel holds great promise for the treatment of bacterial-infected wounds.
文摘目的系统评价透明质酸钠联合A型肉毒毒素治疗面部皱纹的有效性和安全性。方法检索Embase、PubMed、Web of Science、中国知网和万方等数据库,检索时间为建库至2022年4月8日。根据纳入标准及排除标准筛选文献,参考Cochrane手册和NOS量表进行文献质量评价,采用Revman 5.4软件对纳入的文献进行Meta分析。结果本研究共纳入17篇文献,包含随机临床对照试验篇和回顾性研究,共计2284例患者,治疗组(A型肉毒素注射联合透明质酸钠)1142例,对照组(单独注射A型肉毒毒素)1142例。Meta分析结果:治疗组的有效率、维持时间、患者满意度均优于对照组,差异有统计学意义(P<0.05)。治疗组患者的不良反应、复发情况均少于对照组,差异有统计学意义(P<0.05)。结论透明质酸钠联合A型肉毒毒素在治疗面部皱纹方面具有一定的优势,但由于受纳入研究的数量和质量限制,针对面部不同皱纹,二者联合使用时,如何配比能够获得更好的疗效值得继续被探索。
文摘目的对封闭式负压引流技术联合高压氧治疗慢性难愈性创面的临床疗效和安全性进行系统评价。方法检索Embase、Pub Med、Cochrane Library、Web of Science、中国知网(CNKI)和万方数据库等数据库,检索时间为建库至2020年12月28日。根据纳入标准及排除标准筛选文献,参考Cochrane手册和NOS量表进行文献质量评价,使用R语言Meta数据包对纳入的文献进行Meta分析。结果共纳入10篇文献,其中包含随机临床对照试验5篇和回顾性研究5篇,共计591例患者,其中治疗组294例,对照组297例。Meta分析结果:治疗组(封闭式负压引流联合高压氧)在创面愈合率、创面愈合时间、创面面积等方面均优于对照组(封闭式负压引流),差异有统计学意义(P<0.05)。结论封闭式负压引流联合高压氧较单纯负压引流治疗,在难愈性创面治疗方面具有较高的优势,但该结论还需要较大样本和更高质量的随机临床对照试验进一步验证。
