穴位敷贴结合托烷司琼治疗化疗所致恶心呕吐的临床疗效

目的:探讨穴位敷贴结合托烷司琼治疗化疗所致恶心呕吐的临床疗效。方法:选取2019年01月01日至2020年12月31日我科肿瘤铂类化疗病人共60例,随机数字法分为两组,对照组应用常规托烷司琼治疗,治疗组应用穴位敷贴结合托烷司琼治疗,比较两组患者恶心呕吐和生活质量情况。结果:对比两组患者呕吐、恶心程度发现,治疗组患者临床疗效明显优于对照组(P<0.05);对比两组患者中医证候疗效发现,治疗组中医证候疗效明显优于对照组(P<0.05);对比两组患者五羟色胺含量表达发现,治疗组患者五羟色胺含量明显低于对照组(P<0.05);对比两组患者生活质量发现,治疗组患者生活质量明显优于对照组(P<0.05)。结论:化疗导致的恶心呕吐治疗研究中,应用穴位敷贴结合托烷司琼的治疗方法效果理想,提高患者生活质量,临床上可进一步应用推广。

温阳扶正方联合肝动脉化疗栓塞术治疗脾肾阳虚型肝癌患者的临床研究

目的:探究温阳扶正方联合肝动脉化疗栓塞术治疗脾肾阳虚型肝癌患者的临床效果。方法:从我院2017年12月到2019年12月选取60例脾肾阳虚肝癌患者,将患者随机分成两组,每组30例,一组为对照组,采用肝动脉化疗栓塞术治疗;另一组为观察组,采用温阳扶正方联合肝动脉化疗栓塞术治疗。观察比较两组患者的血管内皮生长因子(vascular endothelial growth factor,VEGF)、碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)、肝功能指标水平以及生存质量情况。结果:两组患者治疗后,观察组患者的VEGF、bFGF明显低于对照组(P<0.05),数据差异相比有统计学意义。观察组患者的谷草氨基转移酶(aspartate aminotransfer,AST)、谷丙氨基转移酶(alanine aminotransferase,ALT)、总胆红素(total bilirubin,TBil)、γ-谷氨酰转肽酶(γ-gulutamyl transpeptidase,γ-GT)明显低于对照组,两组数据存在明显差异(P<0.05),差异具有统计学意义。观察组患者的生存质量(KPS)评分明显高于对照组,两组数据存在明显差异(P<0.05),具有统计学意义。结论:温阳扶正方联合肝动脉化疗栓塞术治疗脾肾阳虚肝癌患者,能够有效改善患者的肝功能水平,降低VEGF、bFGF水平,提升患者的生存质量,促进患者的治疗。

大黄甘草汤结合穴位敷贴对非小细胞肺癌化疗致胃肠道反应的效果观察

目的探究大黄甘草汤结合穴位敷贴对非小细胞肺癌(NSCLC)化疗致胃肠道反应的效果。方法选取2018年4月至2020年4月我院收治的NSCLC患者116例。根据治疗方法不同分为观察组(60例)和对照组(56例),2组均进行肿瘤化疗治疗,对照组采用甲磺酸多拉司琼和地塞米松止吐治疗,观察组在对照组基础上采用大黄甘草汤结合穴位敷贴治疗。治疗3个月,观察2组免疫功能、胃肠道反应发生率、生活质量及不良反应。结果与对照组比较,观察组CD4^(+)、CD4^(+)/CD8^(+)、自然杀伤细胞(NK)水平较高(P<0.05)。观察组恶心、呕吐、食欲减退和腹泻总发生率低于对照组(43%与84%)(P<0.05)。与对照组比较,观察组躯体功能、情绪功能、社会功能、角色功能和认知功能得分较高(P<0.05)。与对照组比较,观察组白细胞减少、中性粒细胞减少比例较小(P<0.05);但2组血小板减少、血红蛋白减少比例比较差异无统计学意义(P>0.05)。结论大黄甘草汤结合穴位敷贴可减少NSCLC化疗引起的胃肠道反应和不良反应,有效提高免疫功能,改善生活质量,具有较好的应用前景。

小细胞肺癌合并低钠血症1例病例汇报及相关文献复习

目的:探讨小细胞肺癌发生低钠血症的特点、发生机制和治疗措施。方法:回顾分析1例低钠血症合并小细胞肺癌患者的临床资料。结果:本例患者因肺癌1年余伴咳嗽咯痰、乏力3 d入院,予对症治疗后好转。结论:掌握低钠血症合并小细胞肺癌的临床特点,针对病因纠正低钠血症,从而改善肺癌患者的预后。

Traditional Chinese Medicine syndrome analysis on oxaliplatin-induced peripheral neuropathy and clinical efficacy of Bushen Yiqi formula(补肾益气方):a prospective randomized controlled study

OBJECTIVES:To analyze the distribution characteristics of Traditional Chinese Medicine(TCM)syndromes in patients with oxaliplatin-induced peripheral neuropathy(OIPN)and observe the clinical efficacy of Bushen Yiqi formula(补肾益气方,BSYQF)in treating patients with OIPN.METHODS:A total of 89 patients with OIPN were enrolled in this study.The TCM syndrome characteristics were investigated by frequency analysis methodology after collecting and analyzing the TCM syndrome elements of the patients with the OIPN TCM syndrome element scale.Further,62 cases of cold-dampness obstruction syndrome and kidney-Qi deficiency and cold syndrome were selected and randomly divided into the control group(n=31)and the treatment group(n=31).The patients in the treatment group were treated with modified BSYQF,while those in the control group were treated with mecobalamin tablets for 3 weeks.The Levi sensory neurotoxicity score and the neuro-electrophysiological changes were observed before and after the treatment in both groups.RESULTS:The distribution of TCM syndrome types in 89 patients with OIPN were in order of kidney-Qi deficiency and cold syndrome(44 cases),cold-dampness obstruction syndrome(18 cases),Yin deficiency of liver and kidney syndrome(11 cases),blood stasis obstruction syndrome(7 cases),and dampness-heat obstruction syndrome(5 cases).Improvement in Levi sensory neurotoxicity score:After 3-week treatment,the total effective rate in the treatment group was higher than that in the control group(P<0.05).The subgroup analysis showed that the total effective rate in the treatment group of patients with kidney-Qi deficiency and cold syndrome was higher than that in the control group before and after treatment(P<0.05).Improvement in nerve conduction velocity:The sensory nerve conduction velocity of bilateral ulnar nerves improved in the control group after treatment compared with that before treatment(P<0.05).The sensory and motor nerve conduction velocities of the bilateral ulnar and bilateral peroneal nerves improved in the treatment group compared with those before treatment and after treatment in the control group(P<0.05).CONCLUSIONS:The modified BSYQF had a definite therapeutic effect on the OIPN in patients with kidney-Qi deficiency and cold syndrome and those with cold-dampness obstruction syndrome.It could effectively reduce the grade of peripheral nerve toxicity and improve nerve conduction velocity,and its curative effect was better than that of mecobalamin tablets.