The hypoglycemic effects of crude polysaccharides extracted from five medicinal fungi were evaluated using alloxan-induced diabetic mice.High(1 g/kg)and low(0.5 g/kg)doses of polysaccharides extracted from Cordyceps t...The hypoglycemic effects of crude polysaccharides extracted from five medicinal fungi were evaluated using alloxan-induced diabetic mice.High(1 g/kg)and low(0.5 g/kg)doses of polysaccharides extracted from Cordyceps taii and C.memorabilis caused significant(P<0.01)decreases in mice blood sugar levels.Polysaccharides from Ganoderma lucidum and C.militaris fruit bodies both exhibited weak hypoglycemic effects at significance levels of P<0.01 and P<0.05 for high and low doses,respectively.Polysaccharide extracted from mycelium of a Phellinus sp.was significantly(P<0.05)hypoglycemic at higher dose levels but lower doses had no effect.展开更多
The polysaccharide,adenosine and mannitol components of Cordyceps taii collected from the wild were determined,and the effects of aqueous C.taii extracts on immune functions in mice were investigated using carbon clea...The polysaccharide,adenosine and mannitol components of Cordyceps taii collected from the wild were determined,and the effects of aqueous C.taii extracts on immune functions in mice were investigated using carbon clearance and delayed-type hypersensitivity testing(DTH),and by determining thymic and splenic indices.Polysaccharide,adenosine and mannitol levels in C.taii were 36.20 mg/g,0.27 mg/g and 80.20 mg/g,respectively.Aqueous C.taii extracts partially alleviated the suppressive effects on the thymic and splenic indices caused by cyclophosphamide,and increased nonspecific immunity and cellular immune functions.Toxicity tests revealed that the LD50 for aqueous C.taii extract on oral administration was >69.42 g/kg.展开更多
基金Sponsored by the Foundation of Guangdong Province(No.2005B333701016,2006B20201038)
文摘The hypoglycemic effects of crude polysaccharides extracted from five medicinal fungi were evaluated using alloxan-induced diabetic mice.High(1 g/kg)and low(0.5 g/kg)doses of polysaccharides extracted from Cordyceps taii and C.memorabilis caused significant(P<0.01)decreases in mice blood sugar levels.Polysaccharides from Ganoderma lucidum and C.militaris fruit bodies both exhibited weak hypoglycemic effects at significance levels of P<0.01 and P<0.05 for high and low doses,respectively.Polysaccharide extracted from mycelium of a Phellinus sp.was significantly(P<0.05)hypoglycemic at higher dose levels but lower doses had no effect.
基金the Foundation of Guangdong Province(No.2005B33701016 and No.2006B20201038)
文摘The polysaccharide,adenosine and mannitol components of Cordyceps taii collected from the wild were determined,and the effects of aqueous C.taii extracts on immune functions in mice were investigated using carbon clearance and delayed-type hypersensitivity testing(DTH),and by determining thymic and splenic indices.Polysaccharide,adenosine and mannitol levels in C.taii were 36.20 mg/g,0.27 mg/g and 80.20 mg/g,respectively.Aqueous C.taii extracts partially alleviated the suppressive effects on the thymic and splenic indices caused by cyclophosphamide,and increased nonspecific immunity and cellular immune functions.Toxicity tests revealed that the LD50 for aqueous C.taii extract on oral administration was >69.42 g/kg.
