Effective stress law for rock masses and its application in impoundment analysis based on deformation reinforcement theory

Reservoir impoundment is related to several hydraulic engineering concerns,including irreversible valley contractions,landslides and reservoir-induced earthquakes.However,these phenomena,such as valley contractions,are hardly to be explained by the conventional method.The scientific understanding of water effects during impoundment and their hazards to hydraulic structure are needed.The effective stress law for fissured rock masses is introduced in the elasto-plastic model employing the Drucker-Prager criterion and implemented in the three dimension(3D)nonlinear finite element method(FEM)program Three-dimensional FINite Element(TFINE).The slope deforms towards river-way during impoundment since the increasing pore pressure in fissures changes stress state and leads to additional plastic deformation in the rock materials.The value of Biot coefficient and the influence of water on rock materials are discussed in detail.Thus,the mechanism of slope deformation during the impoundment of Jinping-I arch dam is revealed,and the deformation is accurately measured.The application of the effective stress law provides a method to consider stress assessment,deformation evaluation and stability estimate of hydraulic structures during the impoundment process.This is a beneficial exploration and an improvement of hydraulic engineering design.

含姜黄素中药配伍对2型糖尿病肾病患者肾功能的保护研究

目的观察含姜黄素的中药配伍使用对2型糖尿病肾病(T2DN)肾功能的保护作用。方法将我院70例2型糖尿病患者随机分为治疗组与对照组各35例。对照组予氯沙坦钾片治疗,治疗组予含姜黄素的中药配伍+氯沙坦钾片治疗。比较两组临床疗效,检测并比较两组总胆固醇(TC)、甘油三酯(TG)、尿微量白蛋白(U-mAlb)、血肌酐(Scr)、24 h尿蛋白、同型半胱氨酸(Hcy)、空腹血糖(FPG)、餐后2h血糖(2hPG)、超敏C-反应蛋白(hs-CRP)、白细胞计数(WBC)水平。结果治疗后,治疗组总有效率高于对照组(P<0.05);两组TC、TG、U-mAlb、Scr、24 h尿蛋白、Hcy、FPG、2hPG、hs-CRP、WBC水平低于治疗前,治疗组TC、TG、U-mAlb、Scr、24 h尿蛋白、Hcy、FPG、2 hPG、hs-CRP、WBC水平低于对照组(P<0.05)。结论含姜黄素的中药配伍使用对T2DN肾功能的保护作用显著,可明显降低血脂和血糖,提高肾功能,调节微炎症状态。