The main objective of this study was to evaluate eight kinds of trace element pollutants in groundwater from a typical coal mine area,and carry out a corresponding health risk assessment for the local populace.To do t...The main objective of this study was to evaluate eight kinds of trace element pollutants in groundwater from a typical coal mine area,and carry out a corresponding health risk assessment for the local populace.To do this,34 shallow groundwater(SG)samples and 18 mid-layer groundwater(MG)samples were collected from the Sulin mining area.To minimize the uncertainties in the health risk assessment,this paper relied on Monte Carlo simulations and sensitivity analysis.The results revealed that Sr and Mn contents exceeded their corresponding WHO(Guidelines for drinking water quality,4th edn.Geneva,2011)guidelines and Chinese groundwater standards(GB/T14848-2017),while the other analyzed trace elements remain below those threshold values.The calculated hazard quotient and hazard index values for adults from ingestion exposure to SG and MG were well below the threshold limit of 1.Probabilistic simulations further show that the total cancer risk value above the limit of 1×10^(-6) is 0%for SG and 29.39%for MG.Sensitivity analysis identified the Sr and Cr contents as the most relevant element variables affecting the probabilistic non-carcinogenic and carcinogenic risk values in the model,respectively.展开更多
目的研究维生素E联合小剂量阿司匹林、钙剂、叶酸治疗对子痫前期的预防作用及对母胎结局的影响。方法前瞻性选取2018年1月至2022年1月合肥市第一人民医院收治的150例子痫前期高危孕妇,按照随机数字表法分为对照组和研究组,各75例。研究...目的研究维生素E联合小剂量阿司匹林、钙剂、叶酸治疗对子痫前期的预防作用及对母胎结局的影响。方法前瞻性选取2018年1月至2022年1月合肥市第一人民医院收治的150例子痫前期高危孕妇,按照随机数字表法分为对照组和研究组,各75例。研究组于对照组基础上联合给予维生素E处理,对照组行小剂量阿司匹林、钙剂、叶酸干预,持续至孕36周。比较两组孕妇的子痫前期发生率、治疗前后凝血四项[纤维蛋白原(Fib)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、凝血酶原时间(PT)]、子宫动脉血流参数[阻力指数(RI)、收缩期峰值/舒张末期流速(S/D)、搏动指数(PI)]、母胎结局和新生儿出生指标。结果研究组孕妇子痫前期发生率为9.33%(7/75),明显低于对照组[22.67%(17/75)],差异有统计学意义(P<0.05)。两组孕妇治疗后Fib均明显低于治疗前,APTT、TT、PT均明显高于治疗前,且研究组Fib为(3.92±0.33)g/L,明显低于对照组[(4.15±0.35)g/L],APTT、TT、PT为(27.36±1.85)、(13.72±0.77)、(10.13±0.60)s,均明显高于对照组[(26.28±2.01)、(13.38±0.79)、(9.73±0.64)s],差异均有统计学意义(P<0.05)。两组孕妇治疗后子宫动脉RI、S/D、PI均明显低于治疗前,且研究组为0.37±0.06、1.73±0.45、0.62±0.17,明显低于对照组(0.42±0.08、1.91±0.48、0.70±0.19),差异均有统计学意义(P<0.05)。研究组胎儿生长受限、剖宫产、早产、胎盘早剥发生率为5.33%、13.33%、17.33%、6.67%,均明显低于对照组(16.00%、28.00%、34.67%、18.67%),差异有统计学意义(P<0.05)。研究组新生儿出生孕周、体重、1 min Apgar评分为(37.97±1.06)周、(2.94±0.91)kg、(9.53±0.74)分,均明显高于对照组[(37.22±1.01)周、(2.61±0.85)kg、(9.29±0.65)分],差异均有统计学意义(P<0.05)。结论维生素E联合小剂量阿司匹林、钙剂、叶酸能更有效改善子痫前期高危孕妇的凝血功能及子宫动脉血流动力学,在预防子痫前期发生、改善母胎结局方面具有明显优势。展开更多
The Ordovician conodont faunal provinces were previously divided into the Midcontinent and Atlantic Faunal Regions situated respectively in low and high latitudes, where warm- and cold-water type conodont faunas flour...The Ordovician conodont faunal provinces were previously divided into the Midcontinent and Atlantic Faunal Regions situated respectively in low and high latitudes, where warm- and cold-water type conodont faunas flourished respectively. According to the international correlation this paper proposes the third Ordovician conodont faunal region—Qinling Faunal Region, in which cold-water conodont faunas were well developed in the Early to middle Middle Ordovician and warm-water conodont faunas were well developed in the late Middle and Late Ordovician, indicating that the Qinling Region was situated in high latitudes earlier and in low latitudes later. The origin was only due to plate movement. In the Qinling Region the time interval of the change of the conodont fauna from the cold- to warm-water type was 4 Ma (from 474 to 470 Ma), during which the fauna geographically spanned 40° of latitudes, with a movement velocity of nearly 1.12 m/a, indicating that the high-latitude plates were divorced and reduced in the late Middle Ordovician, while the low-latitude plates were converged and accreted. According to the features of the conodont faunas, the Qinling Faunal Region can be divided into the North Tarim, Wudang, Scandic and Pingliang provinces.展开更多
基金The authors sincerely thank the manuscript handling editors and reviewers for their insightful comments that helped to greatly improve this paper.This study was financially supported by the National Natural Science Foundation of China(41773100)the Natural Science Foundation of Anhui Province(2008085QD192)+5 种基金the Key Project of Excellent Talents support program in colleges and universities(gxyqZD2020048)a doctoral research initiation fund Project(2020BS010)a postdoctoral research initiation fund project(2021BSH001)the fourth batch of excellent academic and technical backbone Projects of Suzhou University(2020XJGG02)the Research Project of Wanbei Coal-Electricity Group Co.Ltd.(2020)and the Project for research activities of academic and technological leaders of Anhui Province(2020D239).
文摘The main objective of this study was to evaluate eight kinds of trace element pollutants in groundwater from a typical coal mine area,and carry out a corresponding health risk assessment for the local populace.To do this,34 shallow groundwater(SG)samples and 18 mid-layer groundwater(MG)samples were collected from the Sulin mining area.To minimize the uncertainties in the health risk assessment,this paper relied on Monte Carlo simulations and sensitivity analysis.The results revealed that Sr and Mn contents exceeded their corresponding WHO(Guidelines for drinking water quality,4th edn.Geneva,2011)guidelines and Chinese groundwater standards(GB/T14848-2017),while the other analyzed trace elements remain below those threshold values.The calculated hazard quotient and hazard index values for adults from ingestion exposure to SG and MG were well below the threshold limit of 1.Probabilistic simulations further show that the total cancer risk value above the limit of 1×10^(-6) is 0%for SG and 29.39%for MG.Sensitivity analysis identified the Sr and Cr contents as the most relevant element variables affecting the probabilistic non-carcinogenic and carcinogenic risk values in the model,respectively.
文摘目的研究维生素E联合小剂量阿司匹林、钙剂、叶酸治疗对子痫前期的预防作用及对母胎结局的影响。方法前瞻性选取2018年1月至2022年1月合肥市第一人民医院收治的150例子痫前期高危孕妇,按照随机数字表法分为对照组和研究组,各75例。研究组于对照组基础上联合给予维生素E处理,对照组行小剂量阿司匹林、钙剂、叶酸干预,持续至孕36周。比较两组孕妇的子痫前期发生率、治疗前后凝血四项[纤维蛋白原(Fib)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、凝血酶原时间(PT)]、子宫动脉血流参数[阻力指数(RI)、收缩期峰值/舒张末期流速(S/D)、搏动指数(PI)]、母胎结局和新生儿出生指标。结果研究组孕妇子痫前期发生率为9.33%(7/75),明显低于对照组[22.67%(17/75)],差异有统计学意义(P<0.05)。两组孕妇治疗后Fib均明显低于治疗前,APTT、TT、PT均明显高于治疗前,且研究组Fib为(3.92±0.33)g/L,明显低于对照组[(4.15±0.35)g/L],APTT、TT、PT为(27.36±1.85)、(13.72±0.77)、(10.13±0.60)s,均明显高于对照组[(26.28±2.01)、(13.38±0.79)、(9.73±0.64)s],差异均有统计学意义(P<0.05)。两组孕妇治疗后子宫动脉RI、S/D、PI均明显低于治疗前,且研究组为0.37±0.06、1.73±0.45、0.62±0.17,明显低于对照组(0.42±0.08、1.91±0.48、0.70±0.19),差异均有统计学意义(P<0.05)。研究组胎儿生长受限、剖宫产、早产、胎盘早剥发生率为5.33%、13.33%、17.33%、6.67%,均明显低于对照组(16.00%、28.00%、34.67%、18.67%),差异有统计学意义(P<0.05)。研究组新生儿出生孕周、体重、1 min Apgar评分为(37.97±1.06)周、(2.94±0.91)kg、(9.53±0.74)分,均明显高于对照组[(37.22±1.01)周、(2.61±0.85)kg、(9.29±0.65)分],差异均有统计学意义(P<0.05)。结论维生素E联合小剂量阿司匹林、钙剂、叶酸能更有效改善子痫前期高危孕妇的凝血功能及子宫动脉血流动力学,在预防子痫前期发生、改善母胎结局方面具有明显优势。
文摘The Ordovician conodont faunal provinces were previously divided into the Midcontinent and Atlantic Faunal Regions situated respectively in low and high latitudes, where warm- and cold-water type conodont faunas flourished respectively. According to the international correlation this paper proposes the third Ordovician conodont faunal region—Qinling Faunal Region, in which cold-water conodont faunas were well developed in the Early to middle Middle Ordovician and warm-water conodont faunas were well developed in the late Middle and Late Ordovician, indicating that the Qinling Region was situated in high latitudes earlier and in low latitudes later. The origin was only due to plate movement. In the Qinling Region the time interval of the change of the conodont fauna from the cold- to warm-water type was 4 Ma (from 474 to 470 Ma), during which the fauna geographically spanned 40° of latitudes, with a movement velocity of nearly 1.12 m/a, indicating that the high-latitude plates were divorced and reduced in the late Middle Ordovician, while the low-latitude plates were converged and accreted. According to the features of the conodont faunas, the Qinling Faunal Region can be divided into the North Tarim, Wudang, Scandic and Pingliang provinces.
