Poly （3, 4-ethylenedioxythiophene） （PEDOT）, together with its dopes, such as poly （styrene sulfonate） （PSS）, has been acknowledged to have a wide range of biomedical applications as an important conducting pol...Poly （3, 4-ethylenedioxythiophene） （PEDOT）, together with its dopes, such as poly （styrene sulfonate） （PSS）, has been acknowledged to have a wide range of biomedical applications as an important conducting polymer. In this study, gelatin can be polymerized into PEDOT/PSS polymers on indium tin oxide （ITO）-coated glass. PEDOT/PSS/gelatin layer on ITO-coated glass significantly decreases electrochemical impedance spectroscopy （EIS） and increases charge delivery capacity relative to the gelatin layer and bare ITO- coated glass, comparable to the PEDOT/PSS layer on ITO-coated glass. PEDOT/PSS/gelatin layer on ITO- coated glass enhances pheochromocytoma （PC 12） cell affinity, possesses a high biocompatibility and promotes PC 12 cell growth by delivery of electrical stimulation. These results suggest that gelatin can be incorporated into the PEDOT/PSS polymers through electrochemical polymerization and the PEDOT/PSS/gelatin layer on ITO-coated glass possesses high electrochemical and biological activities.展开更多
文摘目的探讨乳腺癌患者术后焦虑、抑郁的影响因素,为临床诊治提供依据。方法选取2021年4月至2022年10月在宁夏医科大学总医院超声科乳腺门诊登记复查的200例患者为研究对象,采用一般资料调查问卷、广泛性焦虑自评量表(generalized anxiety disorder-7,GAD-7)、抑郁自评量表(patient health questionnaire-9,PHQ-9)进行调查。收集患者的一般临床资料进行单因素分析,并采用多因素Logistic回归分析探讨影响乳腺癌患者术后焦虑、抑郁状态的危险因素。结果200例患者中,焦虑状态检出率为55.0%、抑郁状态检出率为73.0%,焦虑合并抑郁状态检出率为48.0%。多因素Logistic回归分析显示:术后睡眠质量差、PHQ-9评分高、改良根治术(乳腺全切)为焦虑状态的独立危险因素(OR=5.368、1.269、2.500;P=0.007、0.002、0.031);文化水平低、术后睡眠质量差、GAD-7评分高、改良根治术(乳腺全切)为抑郁状态的独立危险因素(OR=4.619、10.527、1.258、2.321;P=0.001、0.014、0.001、0.046);文化水平低、术后食欲差、术后睡眠质量差、改良根治术(乳腺全切)为焦虑合并抑郁状态的独立危险因素(OR=6.629、6.742、22.154、2.619;P=0.001、0.006、0.001、0.031)。结论乳腺癌患者术后普遍存在焦虑、抑郁情绪,焦虑、抑郁检出率及其严重程度与乳腺癌患者的手术方式、文化水平、经济水平等因素密切相关。
基金Funded by National Natural Science Foundation of China(Nos.11179015,51173108)Innovation Program of Shanghai Municipal Education Commission(No.12ZZ143)
文摘Poly （3, 4-ethylenedioxythiophene） （PEDOT）, together with its dopes, such as poly （styrene sulfonate） （PSS）, has been acknowledged to have a wide range of biomedical applications as an important conducting polymer. In this study, gelatin can be polymerized into PEDOT/PSS polymers on indium tin oxide （ITO）-coated glass. PEDOT/PSS/gelatin layer on ITO-coated glass significantly decreases electrochemical impedance spectroscopy （EIS） and increases charge delivery capacity relative to the gelatin layer and bare ITO- coated glass, comparable to the PEDOT/PSS layer on ITO-coated glass. PEDOT/PSS/gelatin layer on ITO- coated glass enhances pheochromocytoma （PC 12） cell affinity, possesses a high biocompatibility and promotes PC 12 cell growth by delivery of electrical stimulation. These results suggest that gelatin can be incorporated into the PEDOT/PSS polymers through electrochemical polymerization and the PEDOT/PSS/gelatin layer on ITO-coated glass possesses high electrochemical and biological activities.
