The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after injury.However,whether it is possible to stimulate ne...The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after injury.However,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains unknown.In this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic injury.Our findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated neurons.Importantly,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain function.These findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.展开更多
纸质文物包括古籍、书画、档案等,因其蕴含的丰厚历史价值及不易保存的特点受到学术界的关注。为全面宏观地了解纸质文物最新国际研究进展及发展态势,本课题从基础研究和技术研发2个角度,基于Web of Science和Derwent Innovations Inde...纸质文物包括古籍、书画、档案等,因其蕴含的丰厚历史价值及不易保存的特点受到学术界的关注。为全面宏观地了解纸质文物最新国际研究进展及发展态势,本课题从基础研究和技术研发2个角度,基于Web of Science和Derwent Innovations Index数据库,通过文献计量学方法对全球纸质文物研究领域的发展态势进行了全面分析。分析结果显示,全球纸质文物研究自2015年开始快速发展,其中中国处于领先。在基础研究方面,研究热点集中在纸质文物纸张保护研究、纸质文物老化及降解机制、纸质文物内容揭示及保护和纸质文物无损鉴定技术4个主题。在技术研发方面,纸张处理与存储、人工智能和深度学习技术应用、纸质文物展示与保存以及信息检索与数字化管理是主要课题。综合分析表明,纸张保护始终是纸质文物研究的核心议题,先进材料科学、数字化技术、光谱学和成像技术的应用与发展将推动纸质文物保护研究迈向现代化、数字化的新阶段。展开更多
Attempts have been made to use cell transplantation and biomaterials to promote cell proliferation,differentiation,migration,and survival,as well as angiogenesis,in the context of brain injury.However,whether bioactiv...Attempts have been made to use cell transplantation and biomaterials to promote cell proliferation,differentiation,migration,and survival,as well as angiogenesis,in the context of brain injury.However,whether bioactive materials can repair the damage caused by ischemic stroke by activating endogenous neurogenesis and angiogenesis is still unknown.In this study,we applied chitosan gel loaded with basic fibroblast growth factor to the stroke cavity 7 days after ischemic stroke in rats.The gel slowly released basic fibroblast growth factor,which improved the local microenvironment,activated endogenous neural stem/progenitor cells,and recruited these cells to migrate toward the penumbra and stroke cavity and subsequently differentiate into neurons,while enhancing angiogenesis in the penumbra and stroke cavity and ultimately leading to partial functional recovery.This study revealed the mechanism by which bioactive materials repair ischemic strokes,thus providing a new strategy for the clinical application of bioactive materials in the treatment of ischemic stroke.展开更多
基金supported by the National Natural Science Foundation of China,Nos.82272171(to ZY),82271403(to XL),81941011(to XL),31971279(to ZY),31730030(to XL)the Natural Science Foundation of Beijing,No.7222004(to HD).
文摘The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after injury.However,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains unknown.In this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic injury.Our findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated neurons.Importantly,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain function.These findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.
文摘纸质文物包括古籍、书画、档案等,因其蕴含的丰厚历史价值及不易保存的特点受到学术界的关注。为全面宏观地了解纸质文物最新国际研究进展及发展态势,本课题从基础研究和技术研发2个角度,基于Web of Science和Derwent Innovations Index数据库,通过文献计量学方法对全球纸质文物研究领域的发展态势进行了全面分析。分析结果显示,全球纸质文物研究自2015年开始快速发展,其中中国处于领先。在基础研究方面,研究热点集中在纸质文物纸张保护研究、纸质文物老化及降解机制、纸质文物内容揭示及保护和纸质文物无损鉴定技术4个主题。在技术研发方面,纸张处理与存储、人工智能和深度学习技术应用、纸质文物展示与保存以及信息检索与数字化管理是主要课题。综合分析表明,纸张保护始终是纸质文物研究的核心议题,先进材料科学、数字化技术、光谱学和成像技术的应用与发展将推动纸质文物保护研究迈向现代化、数字化的新阶段。
基金supported by the National Natural Science Foundation of China,Nos.81941011(to XL),31771053(to HD),31730030(to XL),31971279(to ZY),31900749(to PH),31650001(to XL),31320103903(to XL),31670988(to ZY)the Natural Science Foundation of Beijing,Nos.7222004(to HD)+1 种基金a grant from Ministry of Science and Technology of China,Nos.2017YFC1104002(to ZY),2017YFC1104001(to XL)a grant from Beihang University,No.JKF-YG-22-B001(to FH)。
文摘Attempts have been made to use cell transplantation and biomaterials to promote cell proliferation,differentiation,migration,and survival,as well as angiogenesis,in the context of brain injury.However,whether bioactive materials can repair the damage caused by ischemic stroke by activating endogenous neurogenesis and angiogenesis is still unknown.In this study,we applied chitosan gel loaded with basic fibroblast growth factor to the stroke cavity 7 days after ischemic stroke in rats.The gel slowly released basic fibroblast growth factor,which improved the local microenvironment,activated endogenous neural stem/progenitor cells,and recruited these cells to migrate toward the penumbra and stroke cavity and subsequently differentiate into neurons,while enhancing angiogenesis in the penumbra and stroke cavity and ultimately leading to partial functional recovery.This study revealed the mechanism by which bioactive materials repair ischemic strokes,thus providing a new strategy for the clinical application of bioactive materials in the treatment of ischemic stroke.
