The Qilian Mountains,located in the northeastern Qinghai-Tibet Plateau,is a sensitive zone of both East Asian summer monsoon(EASM)and westerly winds(WW).The evolution history and driving mechanism of the ecosystem and...The Qilian Mountains,located in the northeastern Qinghai-Tibet Plateau,is a sensitive zone of both East Asian summer monsoon(EASM)and westerly winds(WW).The evolution history and driving mechanism of the ecosystem and hydrologic cycle in this region on long-term timescales have not yet been clarified.In this study,we comprehensively study the hydrologic and ecological evolution history in the sensitive zone since the Last Glacial Maximum(LGM)by integrating surface sediments,paleoclimate records,TraCE-21ka transient simulations,and PMIP3-CMIP5 multi-model simulation.Results show that hydrologic and ecological proxies from surface sediments are significantly different from west to east and mainly divided into three sections:the monsoonaffected region in the eastern Qilian Mountains,the intersection region in the central Qilian Mountains,and the westerly-affected region in the western Qilian Mountains.Meanwhile,paleo-ecological and paleohydrologic reconstructions from the surroundings uncover a synchronous climate evolution that the EASM mainly controls the eastern Qilian Mountains and penetrates the central Qilian Mountains in monsoon intensity maximum,while the WW dominates the central and western Qilian Mountains on both glacial-interglacial and millennial timescales.The simulation results further bear out the glacial humid climate in the central and western Qilian Mountains caused by the enhanced WW,and the humidity maximum in the eastern Qilian Mountains controlled by the strong mid-Holocene monsoon.In general,east-west differences in climate pattern and response for the EASM and the WW are integrally stable on both short-term and long-term timescales.展开更多
圆片级真空封装是提高微电子机械系统(Micro-Electro-Mechanical Systems,MEMS)电场传感器品质因数及批量化制造效率的重要途径.本文提出了一种基于绝缘体上硅(Silicon On Insulator,SOI)-玻璃体上硅(Silicon On Glass,SOG)键合的圆片...圆片级真空封装是提高微电子机械系统(Micro-Electro-Mechanical Systems,MEMS)电场传感器品质因数及批量化制造效率的重要途径.本文提出了一种基于绝缘体上硅(Silicon On Insulator,SOI)-玻璃体上硅(Silicon On Glass,SOG)键合的圆片级真空封装MEMS电场传感器,设计并实现了从传感器敏感结构制备到真空封装的整套圆片级加工工艺.本文建立了传感器的结构电容模型,进行了有限元仿真,分析了传感器的特性,突破了传感器微结构制备与释放、SOI与SOG键合等工艺技术难点.该传感器具有工作电压低、品质因数高的突出优点.实验结果表明,工作电压仅为5 V直流与0.05 V交流电压.在60天测试过程中,传感器品质因数始终保持在5000以上.在0~50 kV/m范围内,传感器灵敏度为0.15 mV/(kV/m),线性度为2.21%,不确定度为4.74%.展开更多
Objective:To explore the mechanism of Qingjin Huatan Decoction in regulating iron metabolism by regulating inflammatory factors in the inflammatory environment of chronic obstructive pulmonary disease.Methods:The COPD...Objective:To explore the mechanism of Qingjin Huatan Decoction in regulating iron metabolism by regulating inflammatory factors in the inflammatory environment of chronic obstructive pulmonary disease.Methods:The COPD model was prepared by tracheal drops of lipopolysaccharide(LPS)combined with smoke.40 rats were randomly divided into normal group,COPD group,roxithromycin western medicine group and Qingjin Huatan Decoction traditional Chinese medicine group(n=10).Post-molding drug administration intervention,Qingjin Huatan Decoction Chinese medicine group was given 14.62 g/kg(Qingjin Huatan Decoction),roxithromycin western medicine group was given 0.01575 g/kg(roxithromycin),COPD group and normal group were given normal saline 10 mL/kg,twice a day.The expressions of Hepcidin,IL-1β,IL-10 and TGF-β1 in serum of rats in each group were detected by ELISA.WesternBlot and qRT-PCR were used to detect the expression of TF and IREB2 protein and mRNA in lung tissues of each group.Results:Compared with the normal group,the contents of serum Hepcidin and IL-10 in COPD group were significantly decreased(P<0.01),while the contents of serum IL-1βand TGF-β1 were significantly increased(P<0.01,P<0.05).Compared with COPD group,the contents of serum Hepcidin and IL-10 were significantly increased in the two drug groups(P<0.01),while the contents of serum IL-1βand TGF-β1 were significantly decreased in the two drug groups(P<0.05).Compared with normal group,TF mRNA and protein expression in COPD group were increased(P<0.01),while IREB2 mRNA and protein expression were decreased(P<0.01).Compared with COPD group,TF mRNA and protein expressions in lung tissues of the two-drug group were decreased(P<0.01,P<0.05),while IREB2 mRNA and protein expressions were increased(P<0.01).Conclusion:Iron metabolism is related to inflammation.Qingjin Huatan Decoction can regulate iron metabolism in inflammatory environment to treat COPD.展开更多
目的基于炎症和营养指标探讨非小细胞肺癌(non-small-cell lung cancer,NSCLC)患者预后的影响因素建立预测总生存期(overall survival,OS)的列线图。方法选取苏州肺癌生存队列2016年1月―2020年1月NSCLC患者371例,随机分为训练队列(n=2...目的基于炎症和营养指标探讨非小细胞肺癌(non-small-cell lung cancer,NSCLC)患者预后的影响因素建立预测总生存期(overall survival,OS)的列线图。方法选取苏州肺癌生存队列2016年1月―2020年1月NSCLC患者371例,随机分为训练队列(n=278)和验证队列(n=93)。在训练队列中,通过Cox比例风险模型确定独立危险因素,构建列线图。通过Bootstrap法和十折交叉验证对模型的性能进行评价。结果训练队列和验证队列的1年生存率分别为83.8%和83.9%,2年生存率分别为65.1%和66.7%。最后纳入模型的变量为吸烟状况、分期、治疗方式、BMI、红细胞分布宽度(red cell distribution width,RDW)、中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)和白蛋白与球蛋白比值(albumin-to-globulin ratio,AGR)(均有P<0.05)。训练队列和验证队列的预测OS的C-index分别为0.824和0.762,模型十折交叉验证的平均准确率为77.3%,ROC曲线下面积(area under the curve,AUC)为0.885(95%CI:0.751~1.000)。结论基于炎症和营养指标构建的列线图可以有效地预测NSCLC患者的总生存期。展开更多
基金supported by the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDA20100102)the National Natural Science Foundation of China(Grant No.42077415)+1 种基金the Second Tibetan Plateau Scientific Expedition and Research Program(STEP)(Grant No.2019QZKK0202)the 111 Project(BP0618001)。
文摘The Qilian Mountains,located in the northeastern Qinghai-Tibet Plateau,is a sensitive zone of both East Asian summer monsoon(EASM)and westerly winds(WW).The evolution history and driving mechanism of the ecosystem and hydrologic cycle in this region on long-term timescales have not yet been clarified.In this study,we comprehensively study the hydrologic and ecological evolution history in the sensitive zone since the Last Glacial Maximum(LGM)by integrating surface sediments,paleoclimate records,TraCE-21ka transient simulations,and PMIP3-CMIP5 multi-model simulation.Results show that hydrologic and ecological proxies from surface sediments are significantly different from west to east and mainly divided into three sections:the monsoonaffected region in the eastern Qilian Mountains,the intersection region in the central Qilian Mountains,and the westerly-affected region in the western Qilian Mountains.Meanwhile,paleo-ecological and paleohydrologic reconstructions from the surroundings uncover a synchronous climate evolution that the EASM mainly controls the eastern Qilian Mountains and penetrates the central Qilian Mountains in monsoon intensity maximum,while the WW dominates the central and western Qilian Mountains on both glacial-interglacial and millennial timescales.The simulation results further bear out the glacial humid climate in the central and western Qilian Mountains caused by the enhanced WW,and the humidity maximum in the eastern Qilian Mountains controlled by the strong mid-Holocene monsoon.In general,east-west differences in climate pattern and response for the EASM and the WW are integrally stable on both short-term and long-term timescales.
文摘圆片级真空封装是提高微电子机械系统(Micro-Electro-Mechanical Systems,MEMS)电场传感器品质因数及批量化制造效率的重要途径.本文提出了一种基于绝缘体上硅(Silicon On Insulator,SOI)-玻璃体上硅(Silicon On Glass,SOG)键合的圆片级真空封装MEMS电场传感器,设计并实现了从传感器敏感结构制备到真空封装的整套圆片级加工工艺.本文建立了传感器的结构电容模型,进行了有限元仿真,分析了传感器的特性,突破了传感器微结构制备与释放、SOI与SOG键合等工艺技术难点.该传感器具有工作电压低、品质因数高的突出优点.实验结果表明,工作电压仅为5 V直流与0.05 V交流电压.在60天测试过程中,传感器品质因数始终保持在5000以上.在0~50 kV/m范围内,传感器灵敏度为0.15 mV/(kV/m),线性度为2.21%,不确定度为4.74%.
基金supported by National Natural Science Foundation Project(8216088,81760848)Guangxi University Young and Middle-aged Teachers Basic Ability Improvement Project(2021KY310)Guangxi Medical and Health Key Cultivation Discipline Construction Project Fund Project。
文摘Objective:To explore the mechanism of Qingjin Huatan Decoction in regulating iron metabolism by regulating inflammatory factors in the inflammatory environment of chronic obstructive pulmonary disease.Methods:The COPD model was prepared by tracheal drops of lipopolysaccharide(LPS)combined with smoke.40 rats were randomly divided into normal group,COPD group,roxithromycin western medicine group and Qingjin Huatan Decoction traditional Chinese medicine group(n=10).Post-molding drug administration intervention,Qingjin Huatan Decoction Chinese medicine group was given 14.62 g/kg(Qingjin Huatan Decoction),roxithromycin western medicine group was given 0.01575 g/kg(roxithromycin),COPD group and normal group were given normal saline 10 mL/kg,twice a day.The expressions of Hepcidin,IL-1β,IL-10 and TGF-β1 in serum of rats in each group were detected by ELISA.WesternBlot and qRT-PCR were used to detect the expression of TF and IREB2 protein and mRNA in lung tissues of each group.Results:Compared with the normal group,the contents of serum Hepcidin and IL-10 in COPD group were significantly decreased(P<0.01),while the contents of serum IL-1βand TGF-β1 were significantly increased(P<0.01,P<0.05).Compared with COPD group,the contents of serum Hepcidin and IL-10 were significantly increased in the two drug groups(P<0.01),while the contents of serum IL-1βand TGF-β1 were significantly decreased in the two drug groups(P<0.05).Compared with normal group,TF mRNA and protein expression in COPD group were increased(P<0.01),while IREB2 mRNA and protein expression were decreased(P<0.01).Compared with COPD group,TF mRNA and protein expressions in lung tissues of the two-drug group were decreased(P<0.01,P<0.05),while IREB2 mRNA and protein expressions were increased(P<0.01).Conclusion:Iron metabolism is related to inflammation.Qingjin Huatan Decoction can regulate iron metabolism in inflammatory environment to treat COPD.
文摘目的基于炎症和营养指标探讨非小细胞肺癌(non-small-cell lung cancer,NSCLC)患者预后的影响因素建立预测总生存期(overall survival,OS)的列线图。方法选取苏州肺癌生存队列2016年1月―2020年1月NSCLC患者371例,随机分为训练队列(n=278)和验证队列(n=93)。在训练队列中,通过Cox比例风险模型确定独立危险因素,构建列线图。通过Bootstrap法和十折交叉验证对模型的性能进行评价。结果训练队列和验证队列的1年生存率分别为83.8%和83.9%,2年生存率分别为65.1%和66.7%。最后纳入模型的变量为吸烟状况、分期、治疗方式、BMI、红细胞分布宽度(red cell distribution width,RDW)、中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)和白蛋白与球蛋白比值(albumin-to-globulin ratio,AGR)(均有P<0.05)。训练队列和验证队列的预测OS的C-index分别为0.824和0.762,模型十折交叉验证的平均准确率为77.3%,ROC曲线下面积(area under the curve,AUC)为0.885(95%CI:0.751~1.000)。结论基于炎症和营养指标构建的列线图可以有效地预测NSCLC患者的总生存期。
