目的目前关于IL-10 rs1800896位点基因多态性与环境危险因素的交互作用研究较少。文章旨在探讨IL-10 rs1800896位点基因多态性与环境危险因素及两者间的交互作用对肺结核发病的影响。方法选取2018至2019年广东省结核病防治单位107例肺...目的目前关于IL-10 rs1800896位点基因多态性与环境危险因素的交互作用研究较少。文章旨在探讨IL-10 rs1800896位点基因多态性与环境危险因素及两者间的交互作用对肺结核发病的影响。方法选取2018至2019年广东省结核病防治单位107例肺结核确诊患者(肺结核组)。另从同期体检的健康人群或当地的健康居民中选取健康对照118例(对照组)。设计调查问卷,收集吸烟、室内采光、室内通风等环境因素并进行单因素分析,采用聚合酶链反应结合测序结果检测IL-10 rs1800896位点基因多态性。运用多因素非条件Logistic回归模型分析相乘交互作用,利用叉生分析法分析相加交互作用。结果多因素Logistic回归分析结果显示,吸烟(OR=3.03,95%CI:1.45~6.33)与肺结核易感相关。超显性模型(AA+GG vs AG)中,肺结核组的AG基因型存在率为对照组的3.69倍,携带AG基因型者肺结核患病风险增加;显性模型(AG+GG vs AA)中,肺结核组的AG+GG基因型存在率为对照组的3.45倍,携带AG+GG基因型者肺结核患病风险增加;等位基因模型(A vs G)中,肺结核组的G等位基因存在率为对照组的2.83倍,携带G等位基因型者肺结核患病风险增加。超显性模型中的AG基因型和显性模型中的AG+GG基因型与吸烟在肺结核的发病中未显示出相乘交互作用(P>0.05)。叉生分析结果显示,携带AG基因型且吸烟者的肺结核患病风险是未携带AG基因型且不吸烟者的11.05倍(OR=11.05,95%CI:1.29~94.69),携带AG+GG基因型且吸烟者的患病风险是未携带AG+GG基因型且不吸烟的11.16倍(OR=11.16,95%CI:1.30~95.75)。结论吸烟可增加肺结核的患病风险,IL-10 rs1800896位点基因多态性与肺结核易感性相关,且与吸烟在肺结核发病过程中未显示出相乘交互作用,但存在一定的相加交互作用。展开更多
Background Susceptibility to coronary artery disease （CAD） and diabetes is encoded by distinct, tightly-linked single nucleotide polymorphisms on chromosome 9p21. This study aimed to examine the association of varia...Background Susceptibility to coronary artery disease （CAD） and diabetes is encoded by distinct, tightly-linked single nucleotide polymorphisms on chromosome 9p21. This study aimed to examine the association of variant rs1333049 on chromosome 9p21.3 with early-onset and severity of CAD in Chinese patients with and without type 2 diabetes, and to determine the possible impact of rs1333049 on glucose metabolism and inflammation pathways. Methods Genotyping of variant rs1333049 on chromosome 9p21.3 was performed in 2387 patients with and without diabetes who were undergoing coronary angiography to evaluate suspected or established CAD. Serum levels of glucose, glycosylated hemoglobin Alc （HbAlo）, insulin, high-sensitivity C-reactive protein, tumor necrosis factor-a, and interleukin-6 were also measured, and compared with each patient＇s genotype. Results The homozygous CC genotype of rs1333049 was significantly associated with CAD in diabetic （OR： 1.270, P=-0.044） and non-diabetic （OR： 1.369, P=0.011） patients after adjusting for traditional risk factors. There was an association between CC genotype and number of diseased vessels in diabetics （P=0.019）, but not in non-diabetics （P=0.126）. Among diabetic patients, CC genotype carriers had an increased risk of early-onset CAD （OR：. 2.367, ,~=-0.008） and greater cumulative atherosclerotic burden compared with non-CC genotype carriers （Gensini score： 31.80＋17.20 vs. 23.09＋_21.63, P=-0.039）. No significant differences were observed between genotypes of rs1333049 in serum levels of glucose, insulin, HbAlc, or inflammatory cytokines for diabetic or non-diabetic patients with CAD. Conclusions This study demonstrated a significant association of rs1333049 polymorphism on chromosome 9p21.3 with CAD in Chinese diabetic and non-diabetic patients. The homozygous CC genotype of rs1333049 confers a magnified risk of early-onset and more severe CAD in diabetic patients through a novel biological pathway unrelated to glucose metabolism or inflammation.展开更多
Background The transradial approach is regarded as a useful vascular site for coronary procedures. The aim of this study was to test whether 4Fr catheters assisted by ACIST variable rate injector system can produce co...Background The transradial approach is regarded as a useful vascular site for coronary procedures. The aim of this study was to test whether 4Fr catheters assisted by ACIST variable rate injector system can produce comparable angiographic quality and reduce the risk of radial artery injury compared to hand manifold 6 Fr catheters. Methods A total of 1816 patients were studied consecutively, among whom 856 patients received coronary angiography by 4 Fr catheters （4Fr group） and 960 patients by 6 Fr catheters （6Fr group）. Angiographic and procedural characteristics were observed and recorded. The luminal inner radial arterial diameter before and after the procedure were collected. Results The baseline clinical characteristics were similar in both groups. There were no significant differences in procedure time, radiation dose and quality scores in both groups （P 〉0.05）, but more contrast media was delivered in the 6Fr group （P 〈0.001）. The mean radial arterial diameter six months after the procedure in the 6Fr group reduced significantly compared to that measured one day prior to the procedure （P 〈0.001）. Conclusions Coronary angiography using the 4Fr catheters with Acist power injection system can achieve an acceptable diagnostic quality while at the same time minimizing radial artery injury and contrast media consumption.展开更多
文摘目的目前关于IL-10 rs1800896位点基因多态性与环境危险因素的交互作用研究较少。文章旨在探讨IL-10 rs1800896位点基因多态性与环境危险因素及两者间的交互作用对肺结核发病的影响。方法选取2018至2019年广东省结核病防治单位107例肺结核确诊患者(肺结核组)。另从同期体检的健康人群或当地的健康居民中选取健康对照118例(对照组)。设计调查问卷,收集吸烟、室内采光、室内通风等环境因素并进行单因素分析,采用聚合酶链反应结合测序结果检测IL-10 rs1800896位点基因多态性。运用多因素非条件Logistic回归模型分析相乘交互作用,利用叉生分析法分析相加交互作用。结果多因素Logistic回归分析结果显示,吸烟(OR=3.03,95%CI:1.45~6.33)与肺结核易感相关。超显性模型(AA+GG vs AG)中,肺结核组的AG基因型存在率为对照组的3.69倍,携带AG基因型者肺结核患病风险增加;显性模型(AG+GG vs AA)中,肺结核组的AG+GG基因型存在率为对照组的3.45倍,携带AG+GG基因型者肺结核患病风险增加;等位基因模型(A vs G)中,肺结核组的G等位基因存在率为对照组的2.83倍,携带G等位基因型者肺结核患病风险增加。超显性模型中的AG基因型和显性模型中的AG+GG基因型与吸烟在肺结核的发病中未显示出相乘交互作用(P>0.05)。叉生分析结果显示,携带AG基因型且吸烟者的肺结核患病风险是未携带AG基因型且不吸烟者的11.05倍(OR=11.05,95%CI:1.29~94.69),携带AG+GG基因型且吸烟者的患病风险是未携带AG+GG基因型且不吸烟的11.16倍(OR=11.16,95%CI:1.30~95.75)。结论吸烟可增加肺结核的患病风险,IL-10 rs1800896位点基因多态性与肺结核易感性相关,且与吸烟在肺结核发病过程中未显示出相乘交互作用,但存在一定的相加交互作用。
文摘Background Susceptibility to coronary artery disease （CAD） and diabetes is encoded by distinct, tightly-linked single nucleotide polymorphisms on chromosome 9p21. This study aimed to examine the association of variant rs1333049 on chromosome 9p21.3 with early-onset and severity of CAD in Chinese patients with and without type 2 diabetes, and to determine the possible impact of rs1333049 on glucose metabolism and inflammation pathways. Methods Genotyping of variant rs1333049 on chromosome 9p21.3 was performed in 2387 patients with and without diabetes who were undergoing coronary angiography to evaluate suspected or established CAD. Serum levels of glucose, glycosylated hemoglobin Alc （HbAlo）, insulin, high-sensitivity C-reactive protein, tumor necrosis factor-a, and interleukin-6 were also measured, and compared with each patient＇s genotype. Results The homozygous CC genotype of rs1333049 was significantly associated with CAD in diabetic （OR： 1.270, P=-0.044） and non-diabetic （OR： 1.369, P=0.011） patients after adjusting for traditional risk factors. There was an association between CC genotype and number of diseased vessels in diabetics （P=0.019）, but not in non-diabetics （P=0.126）. Among diabetic patients, CC genotype carriers had an increased risk of early-onset CAD （OR：. 2.367, ,~=-0.008） and greater cumulative atherosclerotic burden compared with non-CC genotype carriers （Gensini score： 31.80＋17.20 vs. 23.09＋_21.63, P=-0.039）. No significant differences were observed between genotypes of rs1333049 in serum levels of glucose, insulin, HbAlc, or inflammatory cytokines for diabetic or non-diabetic patients with CAD. Conclusions This study demonstrated a significant association of rs1333049 polymorphism on chromosome 9p21.3 with CAD in Chinese diabetic and non-diabetic patients. The homozygous CC genotype of rs1333049 confers a magnified risk of early-onset and more severe CAD in diabetic patients through a novel biological pathway unrelated to glucose metabolism or inflammation.
文摘Background The transradial approach is regarded as a useful vascular site for coronary procedures. The aim of this study was to test whether 4Fr catheters assisted by ACIST variable rate injector system can produce comparable angiographic quality and reduce the risk of radial artery injury compared to hand manifold 6 Fr catheters. Methods A total of 1816 patients were studied consecutively, among whom 856 patients received coronary angiography by 4 Fr catheters （4Fr group） and 960 patients by 6 Fr catheters （6Fr group）. Angiographic and procedural characteristics were observed and recorded. The luminal inner radial arterial diameter before and after the procedure were collected. Results The baseline clinical characteristics were similar in both groups. There were no significant differences in procedure time, radiation dose and quality scores in both groups （P 〉0.05）, but more contrast media was delivered in the 6Fr group （P 〈0.001）. The mean radial arterial diameter six months after the procedure in the 6Fr group reduced significantly compared to that measured one day prior to the procedure （P 〈0.001）. Conclusions Coronary angiography using the 4Fr catheters with Acist power injection system can achieve an acceptable diagnostic quality while at the same time minimizing radial artery injury and contrast media consumption.
