Three lightweight Al_(2)O_(3)-MgO castables were fabricated with tabular alumina or microporous corundum as the aggregates,reactiveα-Al_(2)O_(3)micropowder,tabular alumina powder,and fused magnesia powder as the matr...Three lightweight Al_(2)O_(3)-MgO castables were fabricated with tabular alumina or microporous corundum as the aggregates,reactiveα-Al_(2)O_(3)micropowder,tabular alumina powder,and fused magnesia powder as the matrix,calcium aluminate cement as the binder,and MgO ultrafine powder(d50=5.4μm)and Al(OH)3 ultrafine powder(d50=8.2μm)as additives.The influence of aggregates and ultrafine powders on the properties,including pore size distribution,heat conductivity,thermal shock resistance,and slag resistance of lightweight refractory castables was investigated.The results show that the incorporation of microporous corundum reduces the bulk density of Al_(2)O_(3)-MgO castables,and MgO and Al(OH)3 ultrafine powders further increases the proportion of micropores in castables,which is beneficial to reducing the heat conductivity,and improving the thermal shock resistance and slag resistance of castables.Additionally,MgO ultrafine powder and Al(OH)3 ultrafine powder increase the fluidity and the strength of castables.展开更多
Activation of glial cells(including microglia and astrocytes)appears central to the initiation and progression of neuroinflammation in Alzheimer's disease(AD).The low-density lipoprotein receptor related protein 1...Activation of glial cells(including microglia and astrocytes)appears central to the initiation and progression of neuroinflammation in Alzheimer's disease(AD).The low-density lipoprotein receptor related protein 1(LRP1)is a major receptor for amyloid-β(Aβ),which plays a critical role in AD pathogenesis.LRP1 regulates inflammatory response by modulating the release of pro-inflammatory cytokines and phagocytosis.However,the effects of LRP1 on microglia and astrocytic cells mediated neuroinflammation and their underlying mechanisms in AD remain unclear.展开更多
基金the National Natural Science Foundation of China(grant no.51774218 and 51374162)for providing financial support for this work.
文摘Three lightweight Al_(2)O_(3)-MgO castables were fabricated with tabular alumina or microporous corundum as the aggregates,reactiveα-Al_(2)O_(3)micropowder,tabular alumina powder,and fused magnesia powder as the matrix,calcium aluminate cement as the binder,and MgO ultrafine powder(d50=5.4μm)and Al(OH)3 ultrafine powder(d50=8.2μm)as additives.The influence of aggregates and ultrafine powders on the properties,including pore size distribution,heat conductivity,thermal shock resistance,and slag resistance of lightweight refractory castables was investigated.The results show that the incorporation of microporous corundum reduces the bulk density of Al_(2)O_(3)-MgO castables,and MgO and Al(OH)3 ultrafine powders further increases the proportion of micropores in castables,which is beneficial to reducing the heat conductivity,and improving the thermal shock resistance and slag resistance of castables.Additionally,MgO ultrafine powder and Al(OH)3 ultrafine powder increase the fluidity and the strength of castables.
文摘Activation of glial cells(including microglia and astrocytes)appears central to the initiation and progression of neuroinflammation in Alzheimer's disease(AD).The low-density lipoprotein receptor related protein 1(LRP1)is a major receptor for amyloid-β(Aβ),which plays a critical role in AD pathogenesis.LRP1 regulates inflammatory response by modulating the release of pro-inflammatory cytokines and phagocytosis.However,the effects of LRP1 on microglia and astrocytic cells mediated neuroinflammation and their underlying mechanisms in AD remain unclear.
