Chemokines are a superfamily of small proteins that bind to G protein-coupled receptors on target cells and were originally discovered as mediators of directional migration of immune cells to sites of inflammation and...Chemokines are a superfamily of small proteins that bind to G protein-coupled receptors on target cells and were originally discovered as mediators of directional migration of immune cells to sites of inflammation and injury.In recent years,it has become clear that the function of chemokines extends well beyond the role in leukocyte chemotaxis.They participate in organ development,angiogenesis/angiostasis,leukocyte trafficking and homing,tumorigenesis and metastasis,as well as in immune responses to microbial infection.Therefore, chemokines and their receptors are important targets for modulation of host responses in pathophysiologicai conditions and for therapeutic intervention of human diseases.Cellular & Molecular Immunology.2004;1(2): 95-104.展开更多
Phosphoinositide 3-Kinases (PI3Ks) are proteins coupled to a variety of cell surface receptors and play a key role in signal transduction cascade regulating fundamental cellular functions such as transcription, prol...Phosphoinositide 3-Kinases (PI3Ks) are proteins coupled to a variety of cell surface receptors and play a key role in signal transduction cascade regulating fundamental cellular functions such as transcription, proliferation, and survival. PI3Ks also are important in disease processes such as inflammation and cancer. The aim of this review is to outline current understandings of the PI3K family, mechanism of their activation, their role in inflammatory responses and the development of malignant tumors.展开更多
文摘Chemokines are a superfamily of small proteins that bind to G protein-coupled receptors on target cells and were originally discovered as mediators of directional migration of immune cells to sites of inflammation and injury.In recent years,it has become clear that the function of chemokines extends well beyond the role in leukocyte chemotaxis.They participate in organ development,angiogenesis/angiostasis,leukocyte trafficking and homing,tumorigenesis and metastasis,as well as in immune responses to microbial infection.Therefore, chemokines and their receptors are important targets for modulation of host responses in pathophysiologicai conditions and for therapeutic intervention of human diseases.Cellular & Molecular Immunology.2004;1(2): 95-104.
文摘Phosphoinositide 3-Kinases (PI3Ks) are proteins coupled to a variety of cell surface receptors and play a key role in signal transduction cascade regulating fundamental cellular functions such as transcription, proliferation, and survival. PI3Ks also are important in disease processes such as inflammation and cancer. The aim of this review is to outline current understandings of the PI3K family, mechanism of their activation, their role in inflammatory responses and the development of malignant tumors.