Objective:To evaluate the potential prophylactic activity of traditional polyherbal remedy against malaria.Methods:A traditional polyherbal remedy against malaria from Odisha,India was evaluated for its potential prop...Objective:To evaluate the potential prophylactic activity of traditional polyherbal remedy against malaria.Methods:A traditional polyherbal remedy against malaria from Odisha,India was evaluated for its potential prophylactic activity using in vitro hepatic cell lines assay and the murine malaria system Plasmodium yoelii yoelii/Anopheles stephensi.Results:The polyherbal extract inhibited the Plasmodium yoelii hepatic stages in vitro(IC500.74 mg/m L),a therapeutic index of 9.54.In mice treated with the aqueous extract(2 000 mg/kg/day),peak parasitaemia values were 81%lower in the experimental2.35%±0.14%as compared to controls 12.62%±0.52%(P<0.001),suggesting significant prophylactic activity.Conclusions:The observations provide a proof of concept for a traditional malaria prophylactic remedy used by tribal populations in India.展开更多
Rasayana tantra is one of the eight specialties of Ayurveda.It is a specialized practice in the form of rejuvenative recipes,dietary regimen,special health promoting behaviour and drugs.Properly administered Rasayana ...Rasayana tantra is one of the eight specialties of Ayurveda.It is a specialized practice in the form of rejuvenative recipes,dietary regimen,special health promoting behaviour and drugs.Properly administered Rasayana can bestow the human being with several benefits like longevity,memory,intelligence,freedom from diseases,youthful age,excellence of luster,complexion and voice,optimum strength of physique and sense organs,respectability and brilliance.Various types of plant based Rasayana recipes are mentioned in Ayurveda. Review of the current literature available on Rasayanas indicates that anti-oxidant and immunomodulation are the most studied activities of the Rasayana drugs.Querying in Pubmed database on Rasayanas reveals that single plants as well as poly herbal formulations have been researched on.This article reviews the basics of Rasayana therapy and the published research on different Rasayana drugs for specific health conditions.It also provides the possible directions for future research.展开更多
基金Aquarius Group of Companies,SingaporeETC CAPTURED Programme,the Netherlands(Grant No.DGIS/D)
文摘Objective:To evaluate the potential prophylactic activity of traditional polyherbal remedy against malaria.Methods:A traditional polyherbal remedy against malaria from Odisha,India was evaluated for its potential prophylactic activity using in vitro hepatic cell lines assay and the murine malaria system Plasmodium yoelii yoelii/Anopheles stephensi.Results:The polyherbal extract inhibited the Plasmodium yoelii hepatic stages in vitro(IC500.74 mg/m L),a therapeutic index of 9.54.In mice treated with the aqueous extract(2 000 mg/kg/day),peak parasitaemia values were 81%lower in the experimental2.35%±0.14%as compared to controls 12.62%±0.52%(P<0.001),suggesting significant prophylactic activity.Conclusions:The observations provide a proof of concept for a traditional malaria prophylactic remedy used by tribal populations in India.
基金Supported by the Department of Science and Technology, Government of India,to establish a"National R&D Facility for Rasayana products in Indian System of Medicines"under Drugs&Pharmaceuticals Research Programme(DPRP)
文摘Rasayana tantra is one of the eight specialties of Ayurveda.It is a specialized practice in the form of rejuvenative recipes,dietary regimen,special health promoting behaviour and drugs.Properly administered Rasayana can bestow the human being with several benefits like longevity,memory,intelligence,freedom from diseases,youthful age,excellence of luster,complexion and voice,optimum strength of physique and sense organs,respectability and brilliance.Various types of plant based Rasayana recipes are mentioned in Ayurveda. Review of the current literature available on Rasayanas indicates that anti-oxidant and immunomodulation are the most studied activities of the Rasayana drugs.Querying in Pubmed database on Rasayanas reveals that single plants as well as poly herbal formulations have been researched on.This article reviews the basics of Rasayana therapy and the published research on different Rasayana drugs for specific health conditions.It also provides the possible directions for future research.
