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组蛋白H3 K27M和BRAF V600E共突变的儿童中线Ⅰ级节细胞胶质瘤
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作者 pagès m Beccaria K +2 位作者 Boddaert N 蔡珊珊 王行富 《临床与实验病理学杂志》 CSCD 北大核心 2017年第5期538-538,共1页
节细胞胶质瘤是一种Ⅰ级肿瘤,其特点为MAPK通路突变,包括BRAFV600E突变。最近,伴H3K27M突变的弥漫中线胶质瘤作为一种Ⅳ级的新类型被WHO(2016)新分类收录。
关键词 节细胞胶质瘤 突变 BRAF 中线 组蛋白 儿童 MAPK通路
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嗜铬细胞瘤与颅内出血
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作者 Gelis A. Pelissier J. +2 位作者 Blard J.m. pagès m 王晓琳 《世界核心医学期刊文摘(神经病学分册)》 2005年第4期50-51,共2页
Introduction. Pheochromocytoma is rarely disclosed by intracranial hemorrhage. We report two cases. Observation, The first 26- year- old patient developed subarachnoid hemorrhage due to a ruptured aneurysm of the midd... Introduction. Pheochromocytoma is rarely disclosed by intracranial hemorrhage. We report two cases. Observation, The first 26- year- old patient developed subarachnoid hemorrhage due to a ruptured aneurysm of the middle cerebral artery. The second patient, aged 44 years, had a temporal hematoma. Diagnosis was suggested in both patients by hypertension and elevated urinary catecholamines and confirmed by imaging and MIBG scintigraphy. Adrenal gland tumors, on both glands in the first patient and on the right gland in the second were successfully removed; cranial hypertension totally regressed. Von Hippel Lindau disease was diagnosed by molecular genetics in the first patient. Paroxysmal hypertension could explain the brain hemorrhage in the first patient and may have favored aneurysmal rupture in the second. Conclusion. The relationships between pheochromocytoma and cerebral aneurysm are discussed. 展开更多
关键词 嗜铬细胞瘤 颅内出血 阵发性高血压 双侧肾上腺 肾上腺瘤 脑动脉瘤 蛛网膜下腔出血 瘤体切除 儿茶酚 影像学
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