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化疗药物抵抗性胎盘滋养层细胞瘤伴肺门淋巴结转移:罕见的转移部位 被引量:1
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作者 Metindir J. pak i. +2 位作者 Ozdilekcan C. Eren E. 王伟华 《世界核心医学期刊文摘(妇产科学分册)》 2005年第6期54-54,共1页
Placental site trophoblastic tumor (PSTT) is an uncommon variant of gestational trophoblastic diseases. In most cases, disease is confined to the uterus and treated with a simple hysterectomy. However, 30% of these pa... Placental site trophoblastic tumor (PSTT) is an uncommon variant of gestational trophoblastic diseases. In most cases, disease is confined to the uterus and treated with a simple hysterectomy. However, 30% of these patients will present with metastatic disease. Patients with metastases frequently have progression of disease and die despite aggressive multiagent chemotherapy. We present a case of 33- year- old female with PSTT and metastases to the hilar lymph nodes of the right lung. Primary surgical treatment consisting of abdominal hysterectomy and unilateral salpingo- oophorectomy was followed by six cycles of EMA/CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine) chemotherapy. After the completion of chemotherapy, β hCG titers stayed within normal range, but a repeated CT scan of chest revealed enlargement of the hilar lymph nodes. The patient underwent right thoracotomy with hilar lymph nodes resection. The resected nodules were pathologically consistent with primary PSTT. In this case report, we have determined a PSTT with hilar region metastasis other than parenchyma of lung and confirmed the chemoresistant nature of tumor with the guidance of the previous reports. 展开更多
关键词 肺门淋巴结 转移部位 胎盘滋养层 化疗药物 抵抗性 足叶乙甙 妊娠性 肺门区 子宫切除术 甲氨蝶呤
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