A recent study by Stein et al.1 deciphers how altered ribosomal elongation dynamics in aging contribute to a loss of protein homeostasis,proteostasis.Proteostasis,the balance of protein synthesis,maintenance and degra...A recent study by Stein et al.1 deciphers how altered ribosomal elongation dynamics in aging contribute to a loss of protein homeostasis,proteostasis.Proteostasis,the balance of protein synthesis,maintenance and degradation is severely affected in aging causing aging-associated neurodegenerative diseases.Whereas the contributions of disturbances in protein maintenance and degradation to the development of the disease have attracted much attention over the past decades,there is scant knowledge about protein synthesis dynamics in aging.展开更多
文摘A recent study by Stein et al.1 deciphers how altered ribosomal elongation dynamics in aging contribute to a loss of protein homeostasis,proteostasis.Proteostasis,the balance of protein synthesis,maintenance and degradation is severely affected in aging causing aging-associated neurodegenerative diseases.Whereas the contributions of disturbances in protein maintenance and degradation to the development of the disease have attracted much attention over the past decades,there is scant knowledge about protein synthesis dynamics in aging.
