Objective Oral lichen planus(OLP)is one of the most common oral mucosa diseases,and is mainly mediated by T lymphocytes.The metabolic reprogramming of activated T cells has been shown to transform from oxidative phosp...Objective Oral lichen planus(OLP)is one of the most common oral mucosa diseases,and is mainly mediated by T lymphocytes.The metabolic reprogramming of activated T cells has been shown to transform from oxidative phosphorylation to aerobic glycolysis.The present study investigated the serum levels of glycolysis-related molecules(lactate dehydrogenase,LDH;pyruvic acid,PA;lactic acid,LAC)in OLP,and the correlation with OLP activity was assessed using the reticular,atrophic and erosive lesion(RAE)scoring system.Methods Univariate and multivariate linear regression functions based on scikit-learn were designed to predict the RAE scores in OLP patients,and the performance of these two machine learning functions was compared.Results The results revealed that the serum levels of PA and LAC were upregulated in erosive OLP(EOLP)patients,when compared to healthy volunteers.Furthermore,the LDH and LAC levels were significantly higher in the EOLP group than in the nonerosive OLP(NEOLP)group.All glycolysis-related molecules were positively correlated to the RAE scores.Among these,LAC had a strong correlation.The univariate function that involved the LAC level and the multivariate function that involved all glycolysis-related molecules presented comparable prediction accuracy and stability,but the latter was more time-consuming.Conclusion It can be concluded that the serum LAC level can be a user-friendly biomarker to monitor the OLP activity,based on the univariate function developed in the present study.The intervention of the glycolytic pathway may provide a potential therapeutic strategy.展开更多
癫痫性脑病(epileptic encephalopathy,EE)是以顽固性癫痫发作和脑电活动严重异常为主要特征的一组疾病综合征。儿童期间起病的EE通常还伴有精神运动发育迟缓或倒退。2017年国际抗癫痫联盟(International League Against Epilepsy,ILAE...癫痫性脑病(epileptic encephalopathy,EE)是以顽固性癫痫发作和脑电活动严重异常为主要特征的一组疾病综合征。儿童期间起病的EE通常还伴有精神运动发育迟缓或倒退。2017年国际抗癫痫联盟(International League Against Epilepsy,ILAE)对癫痫分类进行更新,强调使用发育性和癫痫性脑病这一术语,EE用于在癫痫发生前没有发育落后,而且基因突变本身也不会导致发育迟缓的情况,发育性和癫痫性是发挥作用的两个因素[1]。展开更多
隐蔽性强及攻击方式灵活的中间人(Man-in-the-Middle Attack,MITM)攻击是当前物联网(Internet of Things,IoT)智能家居安全面临的最大安全隐患之一.从攻击与防御两个角度提出了基于上下文感知融合的物联网设备配对模型和基于熵的异构物...隐蔽性强及攻击方式灵活的中间人(Man-in-the-Middle Attack,MITM)攻击是当前物联网(Internet of Things,IoT)智能家居安全面临的最大安全隐患之一.从攻击与防御两个角度提出了基于上下文感知融合的物联网设备配对模型和基于熵的异构物联设备指纹生成机制,以对抗型思维并行开展监测与防御方案研究,实现了对隐藏安全威胁的感知与过滤,通过相似度阈值分析测试与评估模型的建立完成了设备安全性验证,具有较好的效果与优势.展开更多
Exploring dimensionality effects on cuprates is important for understanding the nature of high-temperature superconductivity.By atomically layer-by-layer growth with oxide molecular beam epitaxy,we demonstrate that La...Exploring dimensionality effects on cuprates is important for understanding the nature of high-temperature superconductivity.By atomically layer-by-layer growth with oxide molecular beam epitaxy,we demonstrate that La_(2−x)Sr_(x)CuO_(4)(x=0.15)thin films remain superconducting down to 2 unit cells of thickness but quickly reach the maximum superconducting transition temperature at and above 4 unit cells.By fitting the critical magnetic field(μ0H_(c2)),we show that the anisotropy of the film’s superconductivity increases with decreasing film thickness,indicating that the superconductivity of the film gradually evolves from weak three-to two-dimensional character.These results are helpful to gain more insight into the nature of high-temperature superconductivity with dimensionality.展开更多
Temporary spinal cord stimulation(tSCS)can effectively reduce the pain and severity of postherpetic neuralgia(PHN).However,there are no effective and objective methods for predicting the effects of tSCS on PHN.Laser s...Temporary spinal cord stimulation(tSCS)can effectively reduce the pain and severity of postherpetic neuralgia(PHN).However,there are no effective and objective methods for predicting the effects of tSCS on PHN.Laser speckle contrast imaging(LSCI)is frequently used in neurology to evaluate the effectiveness of treatment.To assess the accuracy of LSCI in predicting the impact of tSCS on PHN,14 adult patients receiving tSCS treatments for spinal nerve-innervated(C6-T2)PHN participated in this observational study.Visual analog scale(VAS)assessments and LSCI bloodflow images of the-ngers were recorded after the tSCS procedure.The results showed that the VAS scores of all patients decreased signi-cantly.Moreover,the bloodflow index(BFI)values were signi-cantly higher than they were before the procedure.Increased bloodflow and pain alleviation were positively correlated.The-ndings indicated that spinal nerve PHN(C6-T2)was signi-cantly reduced by tSCS.Pain alleviation by tSCS was positively correlated with increased bloodflow in the hand.The effect of tSCS on PHN may thus be predicted using an independent and consistent indicator such as LSCI.展开更多
CO_2 pyrolysis by thermal plasma was investigated,and a high conversion rate of 33% and energy efficiency of 17% were obtained.The high performance benefited from a novel quenching method,which synergizes the convergi...CO_2 pyrolysis by thermal plasma was investigated,and a high conversion rate of 33% and energy efficiency of 17% were obtained.The high performance benefited from a novel quenching method,which synergizes the converging nozzle and cooling tube.To understand the synergy effect,a computational fluid dynamics simulation was carried out.A quick quenching rate of 10~7Ks(-1) could be expected when the pyrolysis gas temperature decreased from more than 3000 to 1000 K.According to the simulation results,the quenching mechanism was discussed as follows: first,the compressible fluid was adiabatically expanded in the converging nozzle and accelerated to sonic speed,and parts of the heat energy converted to convective kinetic energy; second,the sonic fluid jet into the cooling tube formed a strong eddy,which greatly enhanced the heat transfer between the inverse-flowing fluid and cooling tube.These two mechanisms ensure a quick quenching to prevent the reverse reaction of CO_2 pyrolysis gas when it flows out from the thermal plasma reactor.展开更多
目的探索替雷利珠单抗导致药品不良反应(adverse drug reaction,ADR)的特点,为临床用药安全提供参考。方法回顾性分析首都医科大学附属北京友谊医院2021年7月—2022年12月使用替雷利珠单抗导致ADR的病例,检索自2019年1月至2022年12月Pub...目的探索替雷利珠单抗导致药品不良反应(adverse drug reaction,ADR)的特点,为临床用药安全提供参考。方法回顾性分析首都医科大学附属北京友谊医院2021年7月—2022年12月使用替雷利珠单抗导致ADR的病例,检索自2019年1月至2022年12月PubMed、ScienceDirect、Embase、万方、维普数据库中替雷利珠单抗导致ADR的个案报道,对纳入病例的年龄、性别、原患疾病、ADR的发生时间、临床表现、处理及转归等进行特点分析。结果该院使用替雷利珠单抗导致ADR 8例患者,文献检索纳入22例患者,共计30例ADR,男性占比83.33%(25/30),60岁以上(21例,70.00%)占比最高,ADR多发生在1~2个用药周期内,以皮肤毒性(8例)、胃肠炎(6例)、肾损伤(4例)为主。经对症治疗后,29例患者好转,1例患者死亡。结论该药使用期间应警惕皮肤、胃肠道和肾脏的ADR,并密切监测相关指标变化。展开更多
基金support of the National Natural Science Foundation of China (No. 52074357)National Key Research and Development Program of China (No. 2019YFC1803500)。
基金This work was supported by grants from the National Natural Science Foundation of China(No.62171193)the Natural Science Foundation of Hubei Province(No.2021CFB399)+1 种基金the Foundation of Health Commission of Hubei Province(No.WJ2021M125)the Key Research and Development Project of Hubei Province of China(No.2022BCA033).
文摘Objective Oral lichen planus(OLP)is one of the most common oral mucosa diseases,and is mainly mediated by T lymphocytes.The metabolic reprogramming of activated T cells has been shown to transform from oxidative phosphorylation to aerobic glycolysis.The present study investigated the serum levels of glycolysis-related molecules(lactate dehydrogenase,LDH;pyruvic acid,PA;lactic acid,LAC)in OLP,and the correlation with OLP activity was assessed using the reticular,atrophic and erosive lesion(RAE)scoring system.Methods Univariate and multivariate linear regression functions based on scikit-learn were designed to predict the RAE scores in OLP patients,and the performance of these two machine learning functions was compared.Results The results revealed that the serum levels of PA and LAC were upregulated in erosive OLP(EOLP)patients,when compared to healthy volunteers.Furthermore,the LDH and LAC levels were significantly higher in the EOLP group than in the nonerosive OLP(NEOLP)group.All glycolysis-related molecules were positively correlated to the RAE scores.Among these,LAC had a strong correlation.The univariate function that involved the LAC level and the multivariate function that involved all glycolysis-related molecules presented comparable prediction accuracy and stability,but the latter was more time-consuming.Conclusion It can be concluded that the serum LAC level can be a user-friendly biomarker to monitor the OLP activity,based on the univariate function developed in the present study.The intervention of the glycolytic pathway may provide a potential therapeutic strategy.
文摘癫痫性脑病(epileptic encephalopathy,EE)是以顽固性癫痫发作和脑电活动严重异常为主要特征的一组疾病综合征。儿童期间起病的EE通常还伴有精神运动发育迟缓或倒退。2017年国际抗癫痫联盟(International League Against Epilepsy,ILAE)对癫痫分类进行更新,强调使用发育性和癫痫性脑病这一术语,EE用于在癫痫发生前没有发育落后,而且基因突变本身也不会导致发育迟缓的情况,发育性和癫痫性是发挥作用的两个因素[1]。
文摘隐蔽性强及攻击方式灵活的中间人(Man-in-the-Middle Attack,MITM)攻击是当前物联网(Internet of Things,IoT)智能家居安全面临的最大安全隐患之一.从攻击与防御两个角度提出了基于上下文感知融合的物联网设备配对模型和基于熵的异构物联设备指纹生成机制,以对抗型思维并行开展监测与防御方案研究,实现了对隐藏安全威胁的感知与过滤,通过相似度阈值分析测试与评估模型的建立完成了设备安全性验证,具有较好的效果与优势.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFA1403000)the Na-tional Natural Science Foundation of China(Grant No.12250710675).
文摘Exploring dimensionality effects on cuprates is important for understanding the nature of high-temperature superconductivity.By atomically layer-by-layer growth with oxide molecular beam epitaxy,we demonstrate that La_(2−x)Sr_(x)CuO_(4)(x=0.15)thin films remain superconducting down to 2 unit cells of thickness but quickly reach the maximum superconducting transition temperature at and above 4 unit cells.By fitting the critical magnetic field(μ0H_(c2)),we show that the anisotropy of the film’s superconductivity increases with decreasing film thickness,indicating that the superconductivity of the film gradually evolves from weak three-to two-dimensional character.These results are helpful to gain more insight into the nature of high-temperature superconductivity with dimensionality.
基金supported by the Clinical Frontier Technology Program of the First A±liated Hospital of Jinan University,China(No.JNU1AFCFTP-2022-a01212)the Clinical Research Funds for the First Clinical Medicine College of Jinan University(Grant No.2018006).
文摘Temporary spinal cord stimulation(tSCS)can effectively reduce the pain and severity of postherpetic neuralgia(PHN).However,there are no effective and objective methods for predicting the effects of tSCS on PHN.Laser speckle contrast imaging(LSCI)is frequently used in neurology to evaluate the effectiveness of treatment.To assess the accuracy of LSCI in predicting the impact of tSCS on PHN,14 adult patients receiving tSCS treatments for spinal nerve-innervated(C6-T2)PHN participated in this observational study.Visual analog scale(VAS)assessments and LSCI bloodflow images of the-ngers were recorded after the tSCS procedure.The results showed that the VAS scores of all patients decreased signi-cantly.Moreover,the bloodflow index(BFI)values were signi-cantly higher than they were before the procedure.Increased bloodflow and pain alleviation were positively correlated.The-ndings indicated that spinal nerve PHN(C6-T2)was signi-cantly reduced by tSCS.Pain alleviation by tSCS was positively correlated with increased bloodflow in the hand.The effect of tSCS on PHN may thus be predicted using an independent and consistent indicator such as LSCI.
基金the funding of National Natural Science Foundation of China (Grant No.11775155)
文摘CO_2 pyrolysis by thermal plasma was investigated,and a high conversion rate of 33% and energy efficiency of 17% were obtained.The high performance benefited from a novel quenching method,which synergizes the converging nozzle and cooling tube.To understand the synergy effect,a computational fluid dynamics simulation was carried out.A quick quenching rate of 10~7Ks(-1) could be expected when the pyrolysis gas temperature decreased from more than 3000 to 1000 K.According to the simulation results,the quenching mechanism was discussed as follows: first,the compressible fluid was adiabatically expanded in the converging nozzle and accelerated to sonic speed,and parts of the heat energy converted to convective kinetic energy; second,the sonic fluid jet into the cooling tube formed a strong eddy,which greatly enhanced the heat transfer between the inverse-flowing fluid and cooling tube.These two mechanisms ensure a quick quenching to prevent the reverse reaction of CO_2 pyrolysis gas when it flows out from the thermal plasma reactor.
文摘目的探索替雷利珠单抗导致药品不良反应(adverse drug reaction,ADR)的特点,为临床用药安全提供参考。方法回顾性分析首都医科大学附属北京友谊医院2021年7月—2022年12月使用替雷利珠单抗导致ADR的病例,检索自2019年1月至2022年12月PubMed、ScienceDirect、Embase、万方、维普数据库中替雷利珠单抗导致ADR的个案报道,对纳入病例的年龄、性别、原患疾病、ADR的发生时间、临床表现、处理及转归等进行特点分析。结果该院使用替雷利珠单抗导致ADR 8例患者,文献检索纳入22例患者,共计30例ADR,男性占比83.33%(25/30),60岁以上(21例,70.00%)占比最高,ADR多发生在1~2个用药周期内,以皮肤毒性(8例)、胃肠炎(6例)、肾损伤(4例)为主。经对症治疗后,29例患者好转,1例患者死亡。结论该药使用期间应警惕皮肤、胃肠道和肾脏的ADR,并密切监测相关指标变化。
