Impact of continuous care on cardiac function in patients with lung cancer complicated by coronary heart disease

BACKGROUND Despite sharing similar pathogenic factors,cancer and coronary heart disease(CHD)occur in comparable populations at similar ages and possess similar susceptibility factors.Consequently,it is increasingly commonplace for patients to experience the simultaneous occurrence of cancer and CHD,a trend that is steadily rising.AIM To determine the impacts of continuing care on lung cancer patients with CHD following percutaneous coronary intervention(PCI).METHODS There were 94 lung cancer patients with CHD following PCI who were randomly assigned to the intervention group(n=38)and the control group(n=41).In the intervention group,continuing care was provided,while in the control group,routine care was provided.An evaluation of cardiac and pulmonary function,medication compliance,a 6-min walk test,and patient quality of life was performed.RESULTS Differences between the two groups were significant in left ventricular ejection fraction,6-min walk test,oxygen uptake,quality of life and medication compliance(P<0.05).In comparison with the control group,the enhancement in the intervention group was more significant.The intervention group had more patients with high medication compliance than the control group,with a statistically significant difference(P<0.05).CONCLUSION After undergoing PCI,lung patients with CHD could benefit from continued care in terms of cardiac and pulmonary function,medications compliance,and quality of life.

Numerical Simulation-Based Analysis of the Impact of Overloading on Segmentally Assembled Bridges

Segmentally assembled bridges are increasinglyfinding engineering applications in recent years due to their unique advantages,especially as urban viaducts.Vehicle loads are one of the most important variable loads acting on bridge structures.Accordingly,the influence of overloaded vehicles on existing assembled bridge structures is an urgent concern at present.This paper establishes thefinite element model of the segmentally assembled bridge based on ABAQUS software and analyzes the influence of vehicle overload on an assembled girder bridge struc-ture.First,afinite element model corresponding to the target bridge is established based on ABAQUS software,and the load is controlled to simulate vehicle movement in each area of the traveling zone at different times.Sec-ond,the key cross-sections of segmental girder bridges are monitored in real time based on the force character-istics of continuous girder bridges,and they are compared with the simulation results.Finally,a material damage ontology model is introduced,and the structural damage caused by different overloading rates is compared and analyzed.Results show that thefinite element modeling method is accurate by comparing with on-site measured data,and it is suitable for the numerical simulation of segmental girder bridges;Dynamic sensors installed at 1/4L,1/2L,and 3/4L of the segmental girder main beams could be used to identify the dynamic response of segmental girder bridges;The bottom plate of the segmental girder bridge is mostly damaged at the position where the length of the precast beam section changes and the midspan position.With the increase in load,damage in the direction of the bridge develops faster than that in the direction of the transverse bridge.Thefindings of this study can guide maintenance departments in the management and maintenance of bridges and vehicles.

Phytoestrogen-derived multifunctional ligands for targeted therapy of breast cancer

Nano-targeted delivery systems have been widely used for breast tumor drug delivery.Estrogen receptors are considered to be significant drug delivery target receptors due to their overexpression in a variety of tumor cells.However,targeted ligands have a significant impact on the safety and effectiveness of active delivery systems,limiting the clinical transformation of nanoparticles.Phytoestrogens have shown good biosafety characteristics and some affinity with the estrogen receptor.In the present study,molecular docking was used to select tanshinone IIA(Tan IIA)among phytoestrogens as a target ligand to be used in nanodelivery systems with somemodifications.Modified Tan IIA(Tan-NH2)showed a good biosafety profile and demonstrated tumor-targeting,anti-tumor and anti-tumor metastasis effects.Moreover,the ligand was utilized with the anti-tumor drug Dox-loaded mesoporous silica nanoparticles via chemical modification to generate a nanocomposite Tan-Dox-MSN.Tan-Dox-MSN had a uniform particle size,good dispersibility and high drug loading capacity.Validation experiments in vivo and in vitro showed that it also had a better targeting ability,anti-tumor effect and lower toxicity in normal organs.These results supported the idea that phytoestrogens with high affinity for the estrogen receptor could improve the therapeutic efficacy of nano-targeted delivery systems in breast tumors.

Construction of curcumin-loaded micelles and evaluation of the anti-tumor effect based on angiogenesis

Objective:Inhibition of tumor angiogenesis has become a new targeted tumor therapy.In this study,we established a micellar carrier with a tumor neovascularization-targeting effect modified by the neovascularization-targeting peptide NGR.Methods:The targeted polymer poly(ethylene glycol)-b-poly(lactide-co-glycolide)(PEG-PLGA)modified with Asn–Gly–Arg(NGR)peptide was prepared and characterized by 1H nuclear magnetic resonance and Fourier-transform infrared spectrometry.NGR-PEG-PLGA was used to construct curcumin(Cur)-loaded micelles by the solvent evaporation method.The physicochemical properties of the micelles were also investigated.Additionally,we evaluated the antitumor efficacy of the polymer micelles(PM)using in vitro cytology experiments and in vivo animal studies.Results:The particle size of Cur-NGR-PM was 139.70±2.51 nm,and the drug-loading capacity was 14.37±0.06%.In vitro cytological evaluation showed that NGR-modified micelles showed higher cellular uptake through receptor-mediated endocytosis pathways than did unmodified micelles,leading to the apoptosis of tumor cells.Then,in vivo antitumor experiments showed that the modified micelles significantly inhibited tumor growth and were safe.Conclusions:NGR-modified micelles significantly optimized the therapeutic efficacy of Cur.This strategy offers a viable avenue for cancer treatment.

基于电商精准扶贫的贫困山区物流配送优化研究

当前我国农村贫困山区物流发展相对落后,从而严重阻碍了我国农村经济发展。为此,文中尝试通过改进Dijkstra算法,并将其应用于农村物流配送选址及配送路径的优化,提升农村物流体系效率。

农村电商精准扶贫的问题及对策研究

2013年甘肃陇南成县电商扶贫实践开启了我国电商精准扶贫的序幕。本文以湖南省城步苗族自治县为例,从当前农村电商精准扶贫的发展现状为切入点,分析了农村电商精准扶贫存在的问题,并提出了解决对策。

基于双视角的《电子商务物流》课程教学改革研究

电子商务及物流产业升级发展,迫切需要既懂电商又懂物流的复合型人才。围绕《电子商务物流》课程教学中存在的突出问题进行了分析,从双视角的角度对《电子商务物流》课程进行教学改革研究的必要性以及教学改革的内容进行了探讨,并提出了对《电子商务物流》课程进行教学改革的具体措施。

高职专业群顶岗实习质量监控及评价体系构建实证研究

顶岗实习作为高职"工学结合"人才培养模式的必经之路,已然成为高职教学的重要一环。本文通过分析专业群顶岗实习质量及评价影响因素,从实习管理、过程化监控、实习评价及专业群动态调整四个方面开展高职专业群顶岗实习质量监控及评价体系构建实证研究。

高职专业群顶岗实习管理系统数据库设计

高职专业群顶岗实习管理系统利用My SQL+PHP开发实现,主要从专业群角度实现学生顶岗实习全程监控及管理,通过实践应用,不仅提高了顶岗实习管理效率,也为专业群建设提供了有效的指导。

高职专业群顶岗实习管理系统构建及运用研究

顶岗实习是高职人才培养中实施实践教学的重要一环,是训练学生专业技能、培养学生职业素养的主要途径。但由于顶岗实习的特点及现状使得顶岗实习管理存在诸多问题。为此,我院开发了专业群顶岗实习管理系统并应用于实践,不仅提高了顶岗实习管理效率,加强了顶岗实习过程实时监控,也为专业群建设发展提供了有效的指导。

A nano-cocrystal strategy to improve the dissolution rate and oral bioavailability of baicalein

Baicalein(BE) is one of the main active flavonoids representing the variety of pharmacological effects including anticancer, anti-inflammatory and cardiovascular protective activities, but it's very low solubility, dissolution rate and poor oral absorption limit the therapeutic applications. In this work, a nano-cocrystal strategy was successfully applied to improve the dissolution rate and bioavailability of BE. Baicalein-nicotinamide(BE-NCT) nanococrystals were prepared by high pressure homogenization and evaluated both in vitro and in vivo. Physical characterization results including scanning electron microscopy, dynamic light scattering, powder X-ray diffraction and differential scanning calorimetry demonstrated that BE-NCT nano-cocrystals were changed into amorphous state with mean particle size of 251.53 nm. In the dissolution test, the BE-NCT nano-cocrystals performed 2.17-fold and 2.54-fold enhancement than BE coarse powder in FaSSIF-V2 and FaSSGF. Upon oral administration, the integrated AUC0-t of BE-NCT nano-cocrystals(6.02-fold) was significantly higher than BE coarse powder(1-fold), BE-NCT cocrystals(2.87-fold) and BE nanocrystals(3.32-fold). Compared with BE coarse powder, BE-NCT cocrystals and BE nanocrystals, BENCT nano-cocrystals possessed excellent performance both in vitro and in vivo evaluations.Thus, it can be seen that nano-cocrystal is an appropriate novel strategy for improving dissolution rate and bioavailability of poor soluble natural products such as BE.

Study of penetration mechanism of labrasol on rabbit cornea by Ussing chamber, RT-PCR assay, Western blot and immunohistochemistry

Labrasol, as a non-ionic surfactant, can enhance the permeation and absorption of drugs, and is extensively used in topical, transdermal, and oral pharmaceutical preparations as an emulsifier and absorption enhancer. Recent studies in our laboratory have indicated that labrasol has a strong absorption enhancing effect on different types of drugs in vitro and in vivo. This study was performed to further elucidate the action mechanism of labrasol on the corneal penetration. In this research, the fluorescein sodium, a marker of passive paracellular transport of tight junction, was selected as the model drug to assess the effect of labrasol on in vitro corneal permeability. To investigate the continuous and real-time influence of labrasol on the membrane permeability and integrity, the Ussing chamber system was applied to monitor the electrophysiological parameters. And, furthermore, we elucidated the effect of labrasol on excised cornea at the molecular level by application of RT-PCR, Western blot, and immunohistochemical staining. The results indicated that labrasol obviously enhance the transcorneal permeability of fluorescein sodium, and the enhancement was realized by interacting with and down-regulating the associated proteins, such as Factin, claudin-1 and β-catenin, which were contributed to cell-cell connections, respectively.

Shim coil design for Halbach magnet by equivalent magnetic dipole method

Low-field nuclear magnetic resonance magnet（2 MHz） is required for rock core analysis. However, due to its low field strength, it is hard to achieve a high uniform B0 field only by using the passive shimming. Therefore, active shimming is necessarily used to further improve uniformity for Halbach magnet. In this work, an equivalent magnetic dipole method is presented for designing shim coils. The minimization of the coil power dissipation is considered as an optimal object to minimize coil heating effect, and the deviation from the target field is selected as a penalty function term. The lsqnonlin optimization toolbox of MATLAB is used to solve the optimization problem. Eight shim coils are obtained in accordance with the contour of the stream function. We simulate each shim coil by ANSYS Maxwell software to verify the validity of the designed coils. Measurement results of the field distribution of these coils are consistent with those of the target fields.The uniformity of the B0 field is improved from 114.2 ppm to 26.9 ppm after using these shim coils.

水泥中水溶性铬(Ⅵ)和总铬的主要来源分析

为了查清水泥中水溶性铬(Ⅵ)和总铬的主要来源,对水泥生产原料、水泥窑煅烧、水泥磨粉磨等环节中水溶性铬(Ⅵ)及总铬含量进行了测定。结果显示,水溶性铬(Ⅵ)主要来源于水泥窑煅烧阶段;协同处置会使总铬含量增加,需要合理控制协同处置量;混合材中水溶性铬(Ⅵ)和总铬的含量应定期进行检测,以避免带入的水溶性铬(Ⅵ)和总铬的含量超过设定值。

Mechanical Regulation of Calcium Response and Trail Formation of Neutrophils on Endothelium

Atherosclerosis or fibrosis and cirrhosis undergo chronic inflammation associated with the adhesion between neutrophils and endothelial cells(ECs)that is mediated by their respective cellular adhesive molecules on stiffened blood vessel wall or extracellular matrix(ECM)under shear flow[1-3].However,the mechanical dependence of calcium flux and trail formation in neutrophils remains unclear yet in these processes.First,the effect of substrate stiffness through ECs on neutrophil calcium spike was quantified when the individual neutrophils adhered to EC monolayer pre-placed onto stiffness-varied polyacrylamide(PA)substrate(5 or 34.88 kPa)or glass surface.Our data indicated that E-/P-selectins and ICAM-1s on HUVECs and b2-integrins,PSGL-1s,and CD44s on neutrophils were all involved in mediating neutrophil calcium spike in a stiffness-dependent manner,in which the increase of substrate stiffness enhanced the calcium intensity and spike number.Such stiffness-dependent calcium response is associated with selectin-induced b2-integrin activation through Syk/Src signaling pathway and the F-actin/myosin II function.Moreover,tension-activated calcium ion channels displayed critical roles in initiating stiffness-dependent calcium spike [4].Second,the trail formation of neutrophils to ECs monolayer pre-placed onto the same PA substrate were also tested under shear flow.Live fluorescence imaging showed that neutrophils are able to form long membrane tethers during migration and subsequently leave behind membranous long-lasting trails under shear,which are enriched in LFA-1,Mac-1,and CD44.Moreover,the formation of the trails was inhibited by blocking LFA-1s and Mac-1s,suggesting an important role forβ2-integrins in the trial formation.The recruitment of monocytes was inhibited when pre-blocking ICAM-1s on flowing monocytes,indicating that the neutrophil’s trails employβ2-integrin-ICAM-1 binding to recruit the monocytes.Intriguingly,both the length and the area of the trails increase with increasing substrate stiffness,resulting in the enhanced monocyte recruitment.Inhibition of actin binding protein Arp2/3 impairs the trail formation and dramatically decreases the neutrophil-dependent monocyte recruitment.These data provide an insight into understanding how stiffening of vascular wall could regulate the calcium flux of adhered neutrophils and thus the immune responses in atherosclerosis.They also imply that local mechanical microenvironment is remodeled with the migration of neutrophils,leaving the trails presented to induce and regulate monocyte recruitment.All the results are meaningful in elucidating the occurrence and development of atherosclerosis or fibrosis from the viewpoint of mechanotransduction and also for the potential intervention of cardiovascular disease progress.

Equivalent magnetic dipole method used to design gradient coil for unilateral magnetic resonance imaging

The conventional magnetic resonance imaging(MRI)equipment cannot measure large volume samples nondestructively in the engineering site for its heavy weight and closed structure.In order to realize the mobile MRI,this study focuses on the design of gradient coil of unilateral magnet.The unilateral MRI system is used to image the local area above the magnet.The current density distribution of the gradient coil cannot be used as a series of superconducting nuclear magnetic resonance gradient coils,because the region of interest(ROI)and the wiring area of the unilateral magnet are both cylindrical side arc surfaces.Therefore,the equivalent magnetic dipole method is used to design the gradient coil,and the algorithm is improved for the special case of the wiring area and the ROI,so the X and Y gradient coils are designed.Finally,a flexible printed circuit board(PCB)is used to fabricate the gradient coil,and the magnetic field distribution of the ROI is measured by a Gauss meter,and the measured results match with the simulation results.The gradient linearities of x and y coils are 2.82%and 3.56%,respectively,less than 5%of the commercial gradient coil requirement.

A Polarization Programmable Antenna Array

Reconfigurable antennas are becoming a major antenna technology for future wireless communications and sensing systems.It is known that,with a single linear polarization(LP)reconfigurable antenna element,a preferred polarization can be produced from a set of multiple polarization states,thus improving the quality of the communication link.This paper presents a new concept of a polarization programmable reconfigurable antenna array that consists of a number of polarization reconfigurable antenna elements with a finite number of possible polarization states.By employing a new optimization strategy and programming the polarization states of all the array elements,we demonstrate that it is possible to realize any desired LP in the vectorial array radiation pattern with accurate control of sidelobe and crosspolarization levels(XPLs),thereby achieving the desired polarization to perfectly match that of the required communications signal.Both numerical and experimental results are provided to prove the concept,and they agree well with each other.

大型高冰级破冰LNG船结构设计

针对LNG船在极地高冰级要求下的结构设计问题,基于PC规则和俄罗斯规范对某大型极地破冰LNG船完成满足PC3、PC4和Arc7高冰级要求的三套结构设计方案,探讨艏艉双向破冰要求的冰区加强区域划分方法,分析对比PC3、PC4和Arc7三种冰级冰区加强的要求和计算结果,通过有限元直接计算分析模拟冰载荷对船体结构造成的影响并与规范计算的结果进行比较。

Stretchable and self-healing conductive fibers from hierarchical silver nanowires-assembled network

Conductive fibers(CFs)with features of high conductivity,stretchability,self-healability,and electromechanical stability are key components of the increasingly popular wearable electronics.However,since the lack of structural design of conductive network and interfacial interaction between soft polymer and conductive additives,it is still hard to enable CFs to meet above requirements.Here,we describe a facial drawing method from a hydrogel reservoir which is remolded into ultrathin and stretchable CFs with excellent multi-responsive self-healability.The hydrogel reservoir was fabricated in synergy of an ice-templating method and in situ polymerization using the assembled framework as a crosslinker.Relying on the effective fabrication mechanism,the diameter of CFs could be well-tuned from 90 to 400μm by adjusting the dipping depth of the glass rod,accompanied with conductivity increased from 0.75 to 2.5 S/m.Since the hierarchical network structure was well maintained in the CFs,professional performances have been proved on the stretchability and electromechanical stability.The presence of massive hydrogen bonding and Ag–S bond enabled the CFs with excellent self-healability under the conditions of contact,electric field,and near infrared light,respectively.Excitingly,the CFs with high sensing property could be integrated into an advanced textile sensor through an effective healing-induced integration strategy,demonstrating its great potentials as superior two-dimensional(2D)electronic skins.

Synergistic precipitant powered self-assembly of papain for cross-linked enzyme crystals preparation

In this study,we prepared cross-linked enzyme crystals(CLECs)of papain to further broaden the application of the enzyme with high activity in extreme environments.Initially,papain crystals were successfully obtained based on the micro-batch,batch,and expanded batch crystallization experiments.Specifically,ammonium sulfate and polyethylene glycol 6000(PEG6000)were synergistically used as the precipitants,while L-cysteine was applied to enhance the activity of papain.Furthermore,the interaction between L-cysteine and papain was modeled by molecular docking technique.It was found that L-cysteine could form a hydrogen bond with aspartic acid residue(Asp)at site 158,and the electrostatic attraction with lysine residue(Lys)at site 156 was also quite obvious.Then the enzyme crystals were cross-linked by glutaraldehyde at optimized conditions.The papain CLECs were identified by various methods,and it was found that the thermal stability and enzymatic activity both increased compared to the raw enzyme.More importantly,it could be applied at more rigorous conditions,for example,pH of 4.