Generalized pustulous psoriasis is characterized by the sudden onset of diffuse erythema, with a scattering of pustules, sometimes with fever and others symptoms. It is a relatively rare disease^1. The treatment of tr...Generalized pustulous psoriasis is characterized by the sudden onset of diffuse erythema, with a scattering of pustules, sometimes with fever and others symptoms. It is a relatively rare disease^1. The treatment of traditional western medicine have various adverse drug reactions and easy to recur. Meanwhile, this report describes a 12-year-old female patient of generalized pustulous psoriasis with a satisfactory effect of traditional Chinese medicine.展开更多
Under cyclic loading conditions,the breakdown of rubber products is mainly caused by the formation and spread of cracks.This study focuses on understanding how cracks initiate and grow during the fatigue failure of bl...Under cyclic loading conditions,the breakdown of rubber products is mainly caused by the formation and spread of cracks.This study focuses on understanding how cracks initiate and grow during the fatigue failure of blended rubber.We prepared composite materials by blending bio-mimetic rubber (BMR);butadiene rubber (BR) in different mass ratios and evaluated their resistance to crack initiation and propagation.Our results indicate a clear trend: as the BR content increases,crack initiation in blended rubber is inhibited,while crack propagation is enhanced.This shift leads to a change in the primary factor influencing fatigue fracture from crack initiation to crack propagation.Additionally,we observed that the fatigue life of the rubber blend initially increases and then decreases as the BMR content rises,indicating a critical threshold when the mass ratio of BMR to BR is comparable.By closely examining the materials using a scanning electron microscope (SEM);image analysis,we confirmed that before the threshold,crack initiation is the dominant factor in fatigue failure,while after the threshold,crack propagation takes over.This study provides valuable insights into the mechanisms behind fatigue failure in rubber blends,contributing to a better understanding of this important material behavior.展开更多
OBJECTIVE:To explore the sensitization acupoints of women with primary dysmenorrhea(PD)by comparing infrared radiation temperatures between acupoints and non-acupoints.METHODS:We tested 10 acupoints of every woman wit...OBJECTIVE:To explore the sensitization acupoints of women with primary dysmenorrhea(PD)by comparing infrared radiation temperatures between acupoints and non-acupoints.METHODS:We tested 10 acupoints of every woman with PD and healthy subjects on premenstrual,menstrual,and postmenstrual days using an infrared imaging device.The primary outcome was the absolute value of body surface temperature difference(AVTD)between the left and right sides of the same testing point.RESULTS:A total of 58 PD patients and 57 healthy volunteers completed the test from May 2016 to May 2017.Compared with the healthy group,we observed a significant reduction and increase in the AVTD in Taichong(LR3)and Sanyinjiao(SP6),respectively,during menstrual days in the PD group(P=0.01;P=0.04);while during postmenstrual days,all AVTDs of Shuiquan(KI5),Diji(SP8),and Xuehai(SP10)were diminished in the PD group(P=0.01;P=0.03;P=0.01,respectively).No significant differences in AVTD were detected at any other points or testing times.CONCLUSIONS:Compared with the healthy group,the AVTDs of Taichong(LR3),Sanyinjiao(SP6),Shuiquan(KI5),Diji(SP8),and Xuehai(SP10)at menstruationrelevant points of PD patients were sensitized,providing a reference for the selection of acupoints in the treatment of PD.展开更多
OBJECTIVE:To examine whether direct contact moxibustion(DCM)can prevent and treat gastric cancer(GC)by regulating intestinal flora in rats.METHODS:Male Wistar rats were randomly divided into normal group,normal+DCM co...OBJECTIVE:To examine whether direct contact moxibustion(DCM)can prevent and treat gastric cancer(GC)by regulating intestinal flora in rats.METHODS:Male Wistar rats were randomly divided into normal group,normal+DCM control group,model group,and model+DCM group.Gastric cancer rats were induced by N-methyl-N-nitro-N-nitrosoguanidine(MNNG,20 mg/mL)by gavage.At the same time,the model rats and normal rats were given DCM at Zusanli(ST36),Weishu(BL21),and Zhongwan(CV12)for 16 weeks.After treatment,gastric tissues were collected to analyze the pathological changes and the apoptosis of gastric mucosa cells.In addition,the cecal stool was taken and analyzed by 16 s r RNA sequencing.RESULTS:Gastric cancer-like pathological changes and different abundance of the intestinal flora were found in the model group.DCM promoted mucosa tissue apoptosis and regulated the abnormal changes of the intestinal microflora caused by MNNG;DCM also inhibited the growth of Ruminococcaceae and Prevotellaceae flora and promoted the growth of probiotic Akkermansia.Furthermore,DCM made the composition and abundance of intestinal microflora in the GC rats tending to the normal rats.CONCLUSION:DCM stimulating Zusanli(ST36),Weishu(BL21),and Zhongwan(CV12)promoted the apoptosis of gastric mucosa and delayed the progression of gastric cancer,possibly by decreasing Ruminococcaceae and Prevotellaceae bacteria(bacteria that produce short-chain fatty acids in the intestine)and promoting the growth of probiotic Akkermansia.展开更多
基金Natural Science Foundation of Hebei Province(H2013206097)
文摘Generalized pustulous psoriasis is characterized by the sudden onset of diffuse erythema, with a scattering of pustules, sometimes with fever and others symptoms. It is a relatively rare disease^1. The treatment of traditional western medicine have various adverse drug reactions and easy to recur. Meanwhile, this report describes a 12-year-old female patient of generalized pustulous psoriasis with a satisfactory effect of traditional Chinese medicine.
基金supported by the National Key R&D Program of China (No.2022YFB3707303)the National Natural Science Foundation of China (No.52293471).
文摘Under cyclic loading conditions,the breakdown of rubber products is mainly caused by the formation and spread of cracks.This study focuses on understanding how cracks initiate and grow during the fatigue failure of blended rubber.We prepared composite materials by blending bio-mimetic rubber (BMR);butadiene rubber (BR) in different mass ratios and evaluated their resistance to crack initiation and propagation.Our results indicate a clear trend: as the BR content increases,crack initiation in blended rubber is inhibited,while crack propagation is enhanced.This shift leads to a change in the primary factor influencing fatigue fracture from crack initiation to crack propagation.Additionally,we observed that the fatigue life of the rubber blend initially increases and then decreases as the BMR content rises,indicating a critical threshold when the mass ratio of BMR to BR is comparable.By closely examining the materials using a scanning electron microscope (SEM);image analysis,we confirmed that before the threshold,crack initiation is the dominant factor in fatigue failure,while after the threshold,crack propagation takes over.This study provides valuable insights into the mechanisms behind fatigue failure in rubber blends,contributing to a better understanding of this important material behavior.
基金Supported by National Natural Science Foundation of China:on Acupoints on the Same Spinal Segment Different Meridians Reflecting Primary Dysmenorrhea Based on the Theory of One Source and Three Branches(No.81973755)Research on Variations of Biophysical Properties of Acupoints on Different Meridians with the Same Spinal Segments Based on Primary Dysmenorrhea(No.81573884)+2 种基金Based on the Study of Biophysical Characteristics of the Cytoplasm under Different Physiological States(No.81603542)Ministry of Science and Technology of China:International Cooperation on the Dominant Diseases of Acupuncture and Moxibustion based on the Guiding Principle of Acupoint Compatibility Classification(2019YFC171203)Graduate Innovation Funding Project of Hebei Province:Study on the Mechanism of Acupoint Specific Reaction in Different Pathological States of Uterus(No.XCXZZBS2021013)。
文摘OBJECTIVE:To explore the sensitization acupoints of women with primary dysmenorrhea(PD)by comparing infrared radiation temperatures between acupoints and non-acupoints.METHODS:We tested 10 acupoints of every woman with PD and healthy subjects on premenstrual,menstrual,and postmenstrual days using an infrared imaging device.The primary outcome was the absolute value of body surface temperature difference(AVTD)between the left and right sides of the same testing point.RESULTS:A total of 58 PD patients and 57 healthy volunteers completed the test from May 2016 to May 2017.Compared with the healthy group,we observed a significant reduction and increase in the AVTD in Taichong(LR3)and Sanyinjiao(SP6),respectively,during menstrual days in the PD group(P=0.01;P=0.04);while during postmenstrual days,all AVTDs of Shuiquan(KI5),Diji(SP8),and Xuehai(SP10)were diminished in the PD group(P=0.01;P=0.03;P=0.01,respectively).No significant differences in AVTD were detected at any other points or testing times.CONCLUSIONS:Compared with the healthy group,the AVTDs of Taichong(LR3),Sanyinjiao(SP6),Shuiquan(KI5),Diji(SP8),and Xuehai(SP10)at menstruationrelevant points of PD patients were sensitized,providing a reference for the selection of acupoints in the treatment of PD.
基金Supported by the National Natural Science Fund:the Biophysical Properties Research of Related Acupoints Based on the Physiological State of Uterus(No.81603542)Study on Advantages of Disease and the Law of Micro-Needle Therapy by Using Data Mining Technology(No.81473773)+1 种基金the Project of Improving Scientific Research Ability of Hebei University of Chinese Medicine:the Immune Initiation Effect of Dendritic Cells on Rat with Gastric Cancer Treating by Direct Moxibustion(No.KTZ2019012)Postgraduate Innovation Project of Hebei University of Chinese Medicine:the Immune Initiation Effect of Dendritic Cells on Rat with Gastric Cancer Treating by Direct Moxibustion(No.XCXZZBS2020012)。
文摘OBJECTIVE:To examine whether direct contact moxibustion(DCM)can prevent and treat gastric cancer(GC)by regulating intestinal flora in rats.METHODS:Male Wistar rats were randomly divided into normal group,normal+DCM control group,model group,and model+DCM group.Gastric cancer rats were induced by N-methyl-N-nitro-N-nitrosoguanidine(MNNG,20 mg/mL)by gavage.At the same time,the model rats and normal rats were given DCM at Zusanli(ST36),Weishu(BL21),and Zhongwan(CV12)for 16 weeks.After treatment,gastric tissues were collected to analyze the pathological changes and the apoptosis of gastric mucosa cells.In addition,the cecal stool was taken and analyzed by 16 s r RNA sequencing.RESULTS:Gastric cancer-like pathological changes and different abundance of the intestinal flora were found in the model group.DCM promoted mucosa tissue apoptosis and regulated the abnormal changes of the intestinal microflora caused by MNNG;DCM also inhibited the growth of Ruminococcaceae and Prevotellaceae flora and promoted the growth of probiotic Akkermansia.Furthermore,DCM made the composition and abundance of intestinal microflora in the GC rats tending to the normal rats.CONCLUSION:DCM stimulating Zusanli(ST36),Weishu(BL21),and Zhongwan(CV12)promoted the apoptosis of gastric mucosa and delayed the progression of gastric cancer,possibly by decreasing Ruminococcaceae and Prevotellaceae bacteria(bacteria that produce short-chain fatty acids in the intestine)and promoting the growth of probiotic Akkermansia.
