类风湿关节炎(rheumatoid arthritis,RA)是全身性、持续性、自身免疫性疾病,其病理机制涉及多种免疫细胞,尤其是T淋巴细胞。辅助性T细胞17(relper T cell 17,Th17)和调节性T细胞(regulatory T cell,Treg)是构成免疫系统的关键元素,在维...类风湿关节炎(rheumatoid arthritis,RA)是全身性、持续性、自身免疫性疾病,其病理机制涉及多种免疫细胞,尤其是T淋巴细胞。辅助性T细胞17(relper T cell 17,Th17)和调节性T细胞(regulatory T cell,Treg)是构成免疫系统的关键元素,在维持免疫稳态方面起着重要的作用。对单味中药及其有效成分、中药复方、中成药基于Th17/Treg平衡治疗RA的研究进展进行概括,为RA的临床治疗提供理论指导,为了解RA的发病机制提供新的思路。展开更多
The low level red light irradiation dose that produced positive response on different cell indexes was selected through experiments.In fibroblast detection model,the low level red light irradiation dose that had posit...The low level red light irradiation dose that produced positive response on different cell indexes was selected through experiments.In fibroblast detection model,the low level red light irradiation dose that had positive response to the four indicators of mitochondrial membrane potential,ATP release,cell migration and collagen synthesis was screened.The experimental results showed that low level red light with a irradiation dose of 2 J/cm^(2) had a positive response to the above four indexes in fibroblast.The test model on fibroblast was later transferred to dermal papilla cells for further experimental verification.The results showed that low level red light with a irradiation dose of 2 J/cm^(2) also had a positive response to the four indicators of dermal papilla cells,namely,mitochondrial membrane potential,ATP release,cell proliferation rate and collagen synthesis.It is proved that the low level red light with a irradiation dose of 2 J/cm^(2) could improve the mitochondrial function,cell migration and collagen synthesis of fibroblast and dermal papilla cell,thus providing energy for cell activities,improving cell repair ability and cell anti-aging ability.展开更多
文摘类风湿关节炎(rheumatoid arthritis,RA)是全身性、持续性、自身免疫性疾病,其病理机制涉及多种免疫细胞,尤其是T淋巴细胞。辅助性T细胞17(relper T cell 17,Th17)和调节性T细胞(regulatory T cell,Treg)是构成免疫系统的关键元素,在维持免疫稳态方面起着重要的作用。对单味中药及其有效成分、中药复方、中成药基于Th17/Treg平衡治疗RA的研究进展进行概括,为RA的临床治疗提供理论指导,为了解RA的发病机制提供新的思路。
文摘The low level red light irradiation dose that produced positive response on different cell indexes was selected through experiments.In fibroblast detection model,the low level red light irradiation dose that had positive response to the four indicators of mitochondrial membrane potential,ATP release,cell migration and collagen synthesis was screened.The experimental results showed that low level red light with a irradiation dose of 2 J/cm^(2) had a positive response to the above four indexes in fibroblast.The test model on fibroblast was later transferred to dermal papilla cells for further experimental verification.The results showed that low level red light with a irradiation dose of 2 J/cm^(2) also had a positive response to the four indicators of dermal papilla cells,namely,mitochondrial membrane potential,ATP release,cell proliferation rate and collagen synthesis.It is proved that the low level red light with a irradiation dose of 2 J/cm^(2) could improve the mitochondrial function,cell migration and collagen synthesis of fibroblast and dermal papilla cell,thus providing energy for cell activities,improving cell repair ability and cell anti-aging ability.
