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基于真实世界数据评价罗沙司他治疗维持性透析肾性贫血患者的有效性和安全性 被引量:2
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作者 龚卫卫 朱龙驯 +3 位作者 陈向凡 陈霞 丰攀峰 唐莲 《药物流行病学杂志》 CAS 2023年第8期849-855,共7页
目的比较罗沙司他与促红细胞生成素(EPO)治疗维持性透析肾性贫血患者的临床疗效与安全性。方法采用前瞻性队列研究设计,选取2020年12月—2021年12月就诊于南通市第一人民医院肾内科使用罗沙司他或EPO治疗的肾性贫血伴或不伴慢性心功能... 目的比较罗沙司他与促红细胞生成素(EPO)治疗维持性透析肾性贫血患者的临床疗效与安全性。方法采用前瞻性队列研究设计,选取2020年12月—2021年12月就诊于南通市第一人民医院肾内科使用罗沙司他或EPO治疗的肾性贫血伴或不伴慢性心功能不全的维持性透析患者,比较肾性贫血患者使用罗沙司他或EPO治疗1个月、3个月及6个月后血红蛋白(Hb)、血清铁蛋白(SF)水平,及用药6个月患者心血管系统不良反应发生情况。结果共纳入142例患者,其中罗沙司他组75例,EPO组67例。两组患者基线期年龄、性别、体重、透析方式与持续时间、既往EPO用量、Hb水平、SF水平、转铁蛋白饱和度、心功能分级及血压水平差异均无统计学意义(P>0.05)。治疗1个月、3个月和6个月后,两组患者的Hb水平均较基线期升高(P<0.05);且治疗1个月后,罗沙司他组Hb水平明显高于EPO组(P<0.05),而治疗3个月、6个月后,两组的Hb水平差异无统计学意义(P>0.05)。治疗后,两组的SF水平、心脑血管系统不良反应发生率等指标差异均无统计学意义(P>0.05)。结论与EPO相比,罗沙司他在初始治疗阶段更具优势,可快速升高Hb水平。罗沙司他与EPO的心血管安全性相当。 展开更多
关键词 罗沙司他 促红细胞生成素 肾性贫血 维持性透析 有效性 心血管安全性 真实世界研究
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Right hemicolectomy combined with duodenum-jejunum Roux-en-Y anastomosis for hepatic colon carcinoma invading the duodenum:A single-center case series
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作者 Pei-Gen Liu pan-feng feng Xiang-Fan Chen 《World Journal of Clinical Cases》 SCIE 2023年第5期1049-1057,共9页
BACKGROUND Hepatic colon carcinoma invading the duodenum is not common in clinical practice.Surgical treatment of colonic hepatic cancer that invades the duodenum is difficult,and the surgical risk is high.AIM To disc... BACKGROUND Hepatic colon carcinoma invading the duodenum is not common in clinical practice.Surgical treatment of colonic hepatic cancer that invades the duodenum is difficult,and the surgical risk is high.AIM To discuss the efficacy and safety of duodenum-jejunum Roux-en-Y anastomosis for the treatment of hepatic colon carcinoma invading the duodenum.METHODS From 2016 to 2020,11 patients from Panzhihua Central Hospital diagnosed with hepatic colon carcinoma were enrolled in this study.Clinical and therapeutic effects and prognostic indicators were retrospectively analyzed to determine the efficacy and safety of our surgical procedures.All patients underwent radical resection of right colon cancer combined with duodenum-jejunum Roux-en-Y anastomosis.RESULTS The median tumor size was 65 mm(r50-90).Major complications(ClavienDindoI-II)occurred in 3 patients(27.3%);the average length of hospital stay was 18.09±4.21 d;and only 1 patient(9.1%)was readmitted during the 1st mo after the surgery.The 30-d mortality rate was 0%.After a median follow-up of 41 m(r7-58),the disease-free survival at 1,2,and 3 years was 90.9%,90.9%and 75.8%,respectively;the overall survival at 1,2,and 3 years was 90.9%.CONCLUSION In selected patients,radical resection of right colon cancer combined with duodenum-jejunum Roux-en-Y anastomosis is clinically effective,and the complications are manageable.The surgical procedure also has an acceptable morbidity rate and mid-term survival. 展开更多
关键词 Colonic liver cancer DUODENUM Tumor infiltration Duodenum-jejunum Roux-en-Y anastomosis Case study
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Rectal cancer combined with abdominal tuberculosis: A case report
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作者 Pei-Gen Liu Xiang-Fan Chen pan-feng feng 《World Journal of Clinical Cases》 SCIE 2022年第31期11523-11528,共6页
BACKGROUND It is very rare to suffer from colorectal adenocarcinoma and abdominal tuberculosis simultaneously.Even in a country such as China,where tuberculosis is still endemic,its diagnosis and treatment are challen... BACKGROUND It is very rare to suffer from colorectal adenocarcinoma and abdominal tuberculosis simultaneously.Even in a country such as China,where tuberculosis is still endemic,its diagnosis and treatment are challenging.This article describes in detail a case of rectal cancer complicated by abdominal tuberculosis and its pathological features.CASE SUMMARY We outline the case of a 71-year-old female who was admitted with intermittent blood in the stool over the past year.The patient was diagnosed with low rectal cancer and received neoadjuvant therapy.The patient then returned to the hospital for surgery,but diffusely distributed nodules were found during laparoscopic exploration.The diagnosis of rectal cancer with extensive metastasis was considered during the operation.There was no opportunity for radical surgery.Thus,nodules were taken for pathological examination,and the abdomen was closed.The histopathological diagnosis was tuberculous granuloma,and the patient was treated with standardized anti-tuberculosis drugs in a specialized hospital.Later,the patient again came to our hospital and underwent abdominoperineal resection.She was discharged 10 d after the operation in good clinical condition.CONCLUSION We aim to emphasize the importance of preoperative and postoperative pathological examination in diagnosis and treatment. 展开更多
关键词 Abdominal tuberculosis Rectal cancer Extrapulmonary tuberculosis Peritoneal nodules Case report
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