To the Editor：Small cell lung cancer （SCLC） transformation is one of the most common mechanisms of resistance to epidermal growth factor receptor tyrosine kinase inhibitors （EGFR-TKIs） in non-SCLC （NSCLC）.Howev...To the Editor：Small cell lung cancer （SCLC） transformation is one of the most common mechanisms of resistance to epidermal growth factor receptor tyrosine kinase inhibitors （EGFR-TKIs） in non-SCLC （NSCLC）.However,whether such transformation is one from NSCLC to SCLC or the coexistence of both remains controversial.[1] In this study,we performed next-generation sequencing （NGS） with a panel of 168 tumor genes for consecutive repeat biopsy tissue samples of a lung adenocarcinoma patient harboring EGFR exon 19 deletion （ex19del）.展开更多
文摘To the Editor：Small cell lung cancer （SCLC） transformation is one of the most common mechanisms of resistance to epidermal growth factor receptor tyrosine kinase inhibitors （EGFR-TKIs） in non-SCLC （NSCLC）.However,whether such transformation is one from NSCLC to SCLC or the coexistence of both remains controversial.[1] In this study,we performed next-generation sequencing （NGS） with a panel of 168 tumor genes for consecutive repeat biopsy tissue samples of a lung adenocarcinoma patient harboring EGFR exon 19 deletion （ex19del）.
