The report from the 20th National Congress of China emphasizes the importance of focusing on the clean,low-carbon,and efficient use of energy,increasing financial support,and promoting green upgrading within the indus...The report from the 20th National Congress of China emphasizes the importance of focusing on the clean,low-carbon,and efficient use of energy,increasing financial support,and promoting green upgrading within the industrial sector.This paper,based on annual data,employs the entropy weight method to construct a comprehensive index reflecting the impact of green upgrading in industrial sectors.To delve deeper,it utilizes the DEA model to measure energy efficiency and its subdivision BCC model to break down energy efficiency into technical and scale efficiency.The financial support landscape is examined from the vantage points of both direct and indirect financing.Using a multivariate time series model,this paper thoroughly investigates the influence of energy efficiency and financial support on the green upgrading of the industrial sector.The findings reveal a significant positive impact of both energy efficiency and financial support on green upgrading in industrial industries.Notably,scale efficiency emerges as the primary driver of energy efficiency.Moreover,indirect financing proves to be more effective in promoting financial support than direct financing.The empirical results retain their robustness even after substituting explanatory variables.The study concludes by contextualizing the research findings within the current real-world scenario,offering practical insights,and proposing specific recommendations.展开更多
In order to study the groundwater environment in the Longkou plain,48 groups of water samples are collected,consisting of 7 groups of surface water samples and 41 groups of groundwater samples.The quality of groundwat...In order to study the groundwater environment in the Longkou plain,48 groups of water samples are collected,consisting of 7 groups of surface water samples and 41 groups of groundwater samples.The quality of groundwater in the Longkou Plain is poor,with class V water quality accounting for more than 90%,and no class I,II water quality,sporadic distribution of Class III and IV water quality.The influencing factors of water quality are mainly inorganic indicators such as nitrate,total hardness,chloride,salinity and sulfate,the detection rate of heavy metals is low.Nitrate is the main pollution index in this area,and the increase of nitrate content is closely related to the construction of underground reservoir.Based on the characteristics of groundwater pollution in the Longkou Plain,the in-situ chemical remediation of groundwater pollution is proposed.展开更多
The embryonic mesoderm comprises heterogeneous cell subpopulations with distinct lineage biases.It is unclear whether a bias for the human hematopoietic lineage emerges at this early developmental stage.In this study,...The embryonic mesoderm comprises heterogeneous cell subpopulations with distinct lineage biases.It is unclear whether a bias for the human hematopoietic lineage emerges at this early developmental stage.In this study,we integrated single-cell transcriptomic analyses of human mesoderm cells from embryonic stem cells and embryos,enabling us to identify and define the molecular features of human hematopoietic mesoderm(HM)cells biased towards hematopoietic lineages.We discovered that BMP4 plays an essential role in HM specification and can serve as a marker for HM cells.Mechanistically,BMP4 acts as a downstream target of HDAC1,which modulates the expression of BMP4 by deacetylating its enhancer.Inhibition of HDAC significantly enhances HM specification and promotes subsequent hematopoietic cell differentiation.In conclusion,our study identifies human HM cells and describes new mechanisms for human hematopoietic development.展开更多
Platelets play vital roles in hemostasis,inflammation,and vascular biology.Platelets are also active participants in the immune responses.As vertebrates,zebrafish have a highly conserved hematopoietic system in the de...Platelets play vital roles in hemostasis,inflammation,and vascular biology.Platelets are also active participants in the immune responses.As vertebrates,zebrafish have a highly conserved hematopoietic system in the developmental,cellular,functional,biochemical,and genetic levels with mammals.Thrombocytes in zebrafish are functional homologs of mammalian platelets.Here,we summarized thrombocyte development,function,and related research techniques in zebrafish,and reviewed available zebrafish models of platelet-associated disorders,including congenital amegakaryocytic thrombocytopenia,inherited thrombocytopenia,essential thrombocythemia,and blood coagulation disorders such as gray platelet syndrome.These elegant zebrafish models and methods are crucial for understanding the molecular and genetic mechanisms of thrombocyte development and function,and provide deep insights into related human disease pathophysiology and drug development.展开更多
基金General Research Fund of Philosophy and Social Sciences in Colleges and Universities of Jiangsu Province in 2020(Grant No.2020SJA1008)Fundamental Research Funds for the Central Universities(Grant No.2023SK04)。
文摘The report from the 20th National Congress of China emphasizes the importance of focusing on the clean,low-carbon,and efficient use of energy,increasing financial support,and promoting green upgrading within the industrial sector.This paper,based on annual data,employs the entropy weight method to construct a comprehensive index reflecting the impact of green upgrading in industrial sectors.To delve deeper,it utilizes the DEA model to measure energy efficiency and its subdivision BCC model to break down energy efficiency into technical and scale efficiency.The financial support landscape is examined from the vantage points of both direct and indirect financing.Using a multivariate time series model,this paper thoroughly investigates the influence of energy efficiency and financial support on the green upgrading of the industrial sector.The findings reveal a significant positive impact of both energy efficiency and financial support on green upgrading in industrial industries.Notably,scale efficiency emerges as the primary driver of energy efficiency.Moreover,indirect financing proves to be more effective in promoting financial support than direct financing.The empirical results retain their robustness even after substituting explanatory variables.The study concludes by contextualizing the research findings within the current real-world scenario,offering practical insights,and proposing specific recommendations.
文摘In order to study the groundwater environment in the Longkou plain,48 groups of water samples are collected,consisting of 7 groups of surface water samples and 41 groups of groundwater samples.The quality of groundwater in the Longkou Plain is poor,with class V water quality accounting for more than 90%,and no class I,II water quality,sporadic distribution of Class III and IV water quality.The influencing factors of water quality are mainly inorganic indicators such as nitrate,total hardness,chloride,salinity and sulfate,the detection rate of heavy metals is low.Nitrate is the main pollution index in this area,and the increase of nitrate content is closely related to the construction of underground reservoir.Based on the characteristics of groundwater pollution in the Longkou Plain,the in-situ chemical remediation of groundwater pollution is proposed.
基金supported by the CAMS Innovation Fund for Medical Sciences(2021-I2M-1-073,2021-I2M-1-040,2022-I2M-JB-015)the National Key Research and Development Program of China(2021YFA1100703,2021YFA1103000)+2 种基金Haihe Laboratory of Cell Ecosystem Innovation Fund(22HHXBSS00031)the National Natural Science Foundation of China(82125003,32271161,82200141)Tianjin Municipal Science and Technology Commission Grant(20JCYBJC00240,22ZXSYSY00010,22JCQNJC01270)。
文摘The embryonic mesoderm comprises heterogeneous cell subpopulations with distinct lineage biases.It is unclear whether a bias for the human hematopoietic lineage emerges at this early developmental stage.In this study,we integrated single-cell transcriptomic analyses of human mesoderm cells from embryonic stem cells and embryos,enabling us to identify and define the molecular features of human hematopoietic mesoderm(HM)cells biased towards hematopoietic lineages.We discovered that BMP4 plays an essential role in HM specification and can serve as a marker for HM cells.Mechanistically,BMP4 acts as a downstream target of HDAC1,which modulates the expression of BMP4 by deacetylating its enhancer.Inhibition of HDAC significantly enhances HM specification and promotes subsequent hematopoietic cell differentiation.In conclusion,our study identifies human HM cells and describes new mechanisms for human hematopoietic development.
基金This work was supported by the National Natural Science Foundation of China(Nos.81870100 and 31871475).
文摘Platelets play vital roles in hemostasis,inflammation,and vascular biology.Platelets are also active participants in the immune responses.As vertebrates,zebrafish have a highly conserved hematopoietic system in the developmental,cellular,functional,biochemical,and genetic levels with mammals.Thrombocytes in zebrafish are functional homologs of mammalian platelets.Here,we summarized thrombocyte development,function,and related research techniques in zebrafish,and reviewed available zebrafish models of platelet-associated disorders,including congenital amegakaryocytic thrombocytopenia,inherited thrombocytopenia,essential thrombocythemia,and blood coagulation disorders such as gray platelet syndrome.These elegant zebrafish models and methods are crucial for understanding the molecular and genetic mechanisms of thrombocyte development and function,and provide deep insights into related human disease pathophysiology and drug development.
