Specific and sustained release of nutrients from capsules to the gastrointestinal tract has attracted many attentions in the field of food and drug delivery.In this work,we reported a monoaxial dispersion electrospray...Specific and sustained release of nutrients from capsules to the gastrointestinal tract has attracted many attentions in the field of food and drug delivery.In this work,we reported a monoaxial dispersion electrospraying-ionotropic gelation technique to prepare multicore millimeter-sized spherical capsules for specific and sustained release of fish oil.The spherical capsules had diameters from 2.05 mm to 0.35 mm with the increased applied voltages.The capsules consisted of uniform(at applied voltages of≤10 k V)or nonuniform(at applied voltages of>10 k V)multicores.The obtained capsules had reasonable loading ratios(9.7%-6.3%)due to the multicore structure.In addition,the obtained capsules had specific and sustained release behaviors of fish oil into the small intestinal phase of in vitro gastrointestinal tract and small intestinal tract models.The simple monoaxial dispersion electrospraying-ionotropic gelatin technique does not involve complicated preparation formulations and polymer modification,which makes the technique has a potential application prospect for the fish oil preparations and the encapsulation of functional active substances in the field of food and drug industries.展开更多
Colorectal cancer(CRC)is one of the most common cancers and supplementation of probiotics may be a promising intervention method. The present study aimed to investigate the anti-CRC effects of Lactiplantibacillus plan...Colorectal cancer(CRC)is one of the most common cancers and supplementation of probiotics may be a promising intervention method. The present study aimed to investigate the anti-CRC effects of Lactiplantibacillus plantarum KX041 on a CRC mouse model. The CRC mice were induced by 10 mg/kg azoxymethane and 2% dextran sulfate sodium. L. plantarum KX041 was orally administrated once daily(1 × 10^(9) CFU/mouse). Results showed that L. plantarum KX041 could significantly inhibit inflammation, tumor formation, and induce tumor cells apoptosis. Moreover, this probiotic could ameliorate the damage of intestinal barrier by recovering tight junction protein expression(like Occludin, Claudin-1, and ZO-1)and preventing goblet cell loss. Furthermore, the oxidative stress was alleviated by increasing the level of antioxidant mediators(like GSH and SOD)and reducing the level of oxidative mediators(like MDA and MPO). In addition, treatment with L. plantarum KX041 could directly regulate gut microbiota, thereby increasing the abundance of beneficial bacteria(like SCFAs-producing bacteria, Akkermansia)and decreasing the abundance of harmful bacteria(like pro-inflammatory bacteria, Parasutterella), which in turn raised SCFAs levels and lowered LPS levels. In conclusion, L. plantarum KX041 could effectively ameliorate CRC via reshaping intestinal microenvironment, alleviating inflammation, maintaining intestinal permeability, and attenuating oxidative stress.展开更多
Objective: There are no comprehensive studies on survival outcomes and optimal treatment protocols for cervical esophageal cancer(CEC), due to its rare clinical prevalence. Our objective was to determine the relations...Objective: There are no comprehensive studies on survival outcomes and optimal treatment protocols for cervical esophageal cancer(CEC), due to its rare clinical prevalence. Our objective was to determine the relationship between pathological characteristics, treatment protocols, and survival outcomes in Chinese CEC patients.Methods: A total of 500 Chinese CEC patients were selected from our 500,000 esophageal and gastric cardia carcinoma database(1973–2018). There were two main groups: patients treated with surgery, and patients receiving non-surgical treatments(radiotherapy, radiochemotherapy, and chemotherapy). The Chi-square test and Kaplan–Meier method were used to compare the continuous variables and survival.Results: Among the 500 CEC patients, 278(55.6%) were male, and the median age was 60.9 ± 9.4 years. A total of 496 patients(99.2%) were diagnosed with squamous cell carcinoma. In 171(34.2%) patients who received surgery, 22(12.9%) had undergone laryngectomy. In 322(64.4%) patients who received non-surgical treatments, 245(76.1%) received radiotherapy. Stratified survival analysis showed that only T stage was related with survival outcomes for CEC patients in the surgical group, and the outcomes between laryngectomy and non-laryngectomy patients were similar. It was noteworthy that the 5-year survival rate was similar in CEC patients among the different groups treated with surgery, radiotherapy, chemotherapy, or radiochemotherapy(P = 0.244). Conclusions: The CEC patients had similar survival outcomes after curative esophagectomy and radiotherapy, including those with or without total laryngectomy. These findings suggest that radiotherapy could be the initial choice for treatment of Chinese CEC patients.展开更多
A precise detection of the fault feature parameter of motor current is a new research hotspot in the broken rotor bar(BRB) fault diagnosis of induction motors. Discrete Fourier transform(DFT) is the most popular techn...A precise detection of the fault feature parameter of motor current is a new research hotspot in the broken rotor bar(BRB) fault diagnosis of induction motors. Discrete Fourier transform(DFT) is the most popular technique in this field, owing to low computation and easy realization. However, its accuracy is often limited by the data window length, spectral leakage, fence e ect, etc. Therefore, a new detection method based on a global optimization algorithm is proposed. First, a BRB fault current model and a residual error function are designed to transform the fault parameter detection problem into a nonlinear least-square problem. Because this optimization problem has a great number of local optima and needs to be resolved rapidly and accurately, a joint algorithm(called TR-MBPSO) based on a modified bare-bones particle swarm optimization(BPSO) and trust region(TR) is subsequently proposed. In the TR-MBPSO, a reinitialization strategy of inactive particle is introduced to the BPSO to enhance the swarm diversity and global search ability. Meanwhile, the TR is combined with the modified BPSO to improve convergence speed and accuracy. It also includes a global convergence analysis, whose result proves that the TR-MBPSO can converge to the global optimum with the probability of 1. Both simulations and experiments are conducted, and the results indicate that the proposed detection method not only has high accuracy of parameter estimation with short-time data window, e.g., the magnitude and frequency precision of the fault-related components reaches 10^(-4), but also overcomes the impacts of spectral leakage and non-integer-period sampling. The proposed research provides a new BRB detection method, which has enough precision to extract the parameters of the fault feature components.展开更多
1.The object-to-human transmission route of SARS-CoV-2 At the time of writing,coronavirus disease 2019(COVID-19),which is caused by the severe acute respiratory syndrome coron-avirus 2(SARS-CoV-2),has been a global pa...1.The object-to-human transmission route of SARS-CoV-2 At the time of writing,coronavirus disease 2019(COVID-19),which is caused by the severe acute respiratory syndrome coron-avirus 2(SARS-CoV-2),has been a global pandemic for more than a year.As of 22 September 2021,the global cumulative incidence exceeds 229 million cases,and the number of deaths has exceeded 4.75 million[1].The current situation of epidemic prevention and control within the countries around the world can be roughly divided into two stages:the pandemic stage that the United States,the United Kingdom,and India are still experiencing(as of 23 September 2021,newly reported cases in the last 24 h in the United States,United Kingdom,and India are 202840,31095,and 26964,respectively[1]);and the normalized epidemic pre-vention and control stage that countries such as China and New Zealand are currently in.展开更多
The limited wide applicability of commercial Mg alloys is mainly attributed to the poor corrosion resistance.Addition of alloying elements is the simplest and effective method to improve the corrosion properties.Based...The limited wide applicability of commercial Mg alloys is mainly attributed to the poor corrosion resistance.Addition of alloying elements is the simplest and effective method to improve the corrosion properties.Based on the low-cost alloy composition design,the corro-sion behavior of commercial Mg-3Al-1Zn(AZ31)alloy bearing minor Ca or Sn element was characterized by scanning Kelvin probe force microscopy,hydrogen evolution,electrochemical measurements,and corrosion morphology analysis.Results revealed that the potential differ-ence of Al_(2)Ca/α-Mg and Mg_(2)Sn/α-Mg was(230±19)mV and(80±6)mV,respectively,much lower than that of Al_(8)Mn_(5)/α-Mg(430±31)mV in AZ31 alloy,which illustrated that AZ31-0.2Sn alloy performed the best corrosion resistance,followed by AZ31-0.2Ca,while AZ31 al-loy exhibited the worst corrosion resistance.Moreover,Sn dissolved into matrix obviously increased the potential ofα-Mg and participated in the formation of dense SnO_(2) film at the interface of matrix,while Ca element was enriched in the corrosion product layer,resulting in the cor-rosion product layer of AZ31-0.2Ca/Sn alloys more compact,stable,and protective than AZ31 alloy.Therefore,AZ31 alloy bearing 0.2wt%Ca or Sn element exhibited excellent balanced properties,which is potential to be applied in commercial more comprehensively.展开更多
Flexible rechargeable aqueous zinc-ion batteries(ZIBs)have attracted extensive attentions in the energy storage field due to their high safety,environmental friendliness,and outstanding electrochemical performance whi...Flexible rechargeable aqueous zinc-ion batteries(ZIBs)have attracted extensive attentions in the energy storage field due to their high safety,environmental friendliness,and outstanding electrochemical performance while the exploration of high-voltage aqueous ZIBs with excellent rate capability is still a great challenge for the further application them in flexible and wearable electronics.Herein,we fabricated a 2.4 V high-voltage flexible aqueous ZIB,being among the highest voltage reported in aqueous ZIBs.Moreover,it exhibits extremely flat charging/discharging voltage platforms and the dropout voltage is only 0.1 V,which is the smallest gap in all aqueous batteries to our best knowledge.Furthermore,the prepared ZIB performs high rate capability of 25 C and energy density of 120 Wh kg?1 and exhibits excellent safety under various destructive conditions including hammering,sewing,punching,and soaking.These extraordinary results indicate the great application potential of our high-voltage flexible aqueous ZIB in wearable electronics.展开更多
Owing to the high carrier mobility,two-dimensional(2D)gallium antimonite(GaSb)is a promising channel material for field-effect transistors(FETs)in the post-silicon era.We investigated the ballistic performance of the ...Owing to the high carrier mobility,two-dimensional(2D)gallium antimonite(GaSb)is a promising channel material for field-effect transistors(FETs)in the post-silicon era.We investigated the ballistic performance of the 2D GaSb metal-oxide-semiconductor FETs with a 10 nm-gate-length by the ab initio quantum transport simulation.Because of the wider bandgap and better gate-control ability,the performance of the 10-nm monolayer(ML)GaSb FETs is generally superior to the bilayer counterparts,including the three-to-four orders of magnitude larger on-current.Via hydrogenation,the delaytime and power consumption can be further enhanced with magnitude up to 35%and 57%,respectively,thanks to the expanded bandgap.The 10-nm ML GaSb FETs can almost meet the International Technology Roadmap for Semiconductors(ITRS)for high-performance demands in terms of the on-state current,intrinsic delay time,and power-delay product.展开更多
Periodontal disease is the leading cause of tooth loss,which is also a high-risk factor for other diseases including oral cancer and cardiovascular disease.Periodontitis is one of the most common type of periodontal d...Periodontal disease is the leading cause of tooth loss,which is also a high-risk factor for other diseases including oral cancer and cardiovascular disease.Periodontitis is one of the most common type of periodontal diseases.Interleukin-1β(IL-1β)plays a key role in the pathogenesis of periodontitis.However,the mechanism how IL-1βis produced during periodontitis is still unclear.In the present study,we found that humanβ-defensin 2(hBD2)enhances IL-1βproduction through an LPS-primed human acute monocytic leukemia(THP-1)macrophage model.Inhibition of P2X purinoceptor 7(P2X7)reduced hBD2-enhanced IL-1βproduction.Incubation of LPS-primed THP-1 macrophages with potassium chloride also suppressed hBD2-enhanced IL-1βproduction.Silence of inflammasome adaptor Nod-like receptor family pyrin domain containing 3(NLRP3)led to reduced hBD2-enhanced IL-1βproduction.Likewise,inhibition of caspase-1 also resulted in the decrease of IL-1β.Moreover,an ethidium bromide uptake test indicated that hBD2-activated caspase-1 mediated pyroptotic pore formation.Subsequent lactate dehydrogenase detection and flow cytometric analysis indicated that hBD2 also induced pyroptosis.In brief,these findings illustrated not only the mechanism of hBD2 in enhancing the inflammatory response,but also provided novel therapeutic targets for periodontitis.展开更多
In this study, four phosphorus-inefficient soybean genotypes （1903, 1305, D17 and D18） and four phosphorus-efficient soybean genotypes （D31, D34, D37 and D38 ） were selected as experimental materials for soil cult...In this study, four phosphorus-inefficient soybean genotypes （1903, 1305, D17 and D18） and four phosphorus-efficient soybean genotypes （D31, D34, D37 and D38 ） were selected as experimental materials for soil culture experiment under high and low phosphorus treatments, to investigate the grain yield, phosphorus content, phosphorus uptake and the relationship between phosphorus utilization efficiency and phosphorus efficiency of soybean genotypes with different phos- phorus efficiency in mature period. According to the experimental results, under low phosphorus treatment, four phosphorus-efficient soybean genotypes exhibited significantly high phosphorus uptake in mature period, especially for D31 and D37; however, three phosphorus-efficient genotypes showed no advantages in adapta- bility of phosphorus utilization efficiency, while only I）31 exhibited high phosphorus utilization and absorption capacity. Correlation analysis and path analysis showed that phosphorus deficiency of soybean was mainly detemained by phosphorus absorption capacity, and phosphorus deficiency under （-P） treatment was sig- nificandy higher than （ ＋ P） treatment. Phosphorus uptake and phosphorus utilization efficiency posed great direct effects on phosphorus efficiency, and phosphorus uptake exhibited a greater contribution ; in addition, these two factors both posed small indirect effects. In mature period at reproductive growth stage, phosphorus absorption efficiency （phosphorus uptake） was the main variation source of phosphorus efficiency of various soybean genotypes in mature period. Therefore, strong phosphorus uptake and accumulation capacity of phosphorus-efficient soybean genotypes in mature period is an important nutrition foundation for the information of high grain yield.展开更多
The insulin-like growth factor(IGF)axis plays important roles in cancer development and metastasis.The type 1 IGF receptor(IGF-1R)is a key member in the IGF axis and has long been recognized for its oncogenic role in ...The insulin-like growth factor(IGF)axis plays important roles in cancer development and metastasis.The type 1 IGF receptor(IGF-1R)is a key member in the IGF axis and has long been recognized for its oncogenic role in multiple cancer lineages.Here we review the occurrence of IGF-1R aberrations and activation mechanisms in cancers,which justify the development of anti-IGF-1R therapies.We describe the therapeutic agents available for IGF-1R inhibition,with focuses on the recent or ongoing pre-clinical and clinical studies.These include antisense oligonucleotide,tyrosine kinase inhibitors and monoclonal antibodies which may be conjugated with cytotoxic drug.Remarkably,simultaneous targeting of IGF-1R and several other oncogenic vulnerabilities has shown early promise,highlighting the potential benefits of combination therapy.Further,we discuss the challenges in targeting IGF-1R so far and new concepts to improve therapeutic efficacy such as blockage of the nuclear translocationofIGF-1R.展开更多
Let(H,αH,βH,ψH,ωH,SH)be a BiHom-Hopf algebra and(A,αA,βA)be an(H,αH,βH,ψH,ωH)-BiHom-bimodule algebra,where the mapsαH,βH,ψH,ωH,αA,βA are bijective.We first prove the Maschke-type theorem for the BiHom-...Let(H,αH,βH,ψH,ωH,SH)be a BiHom-Hopf algebra and(A,αA,βA)be an(H,αH,βH,ψH,ωH)-BiHom-bimodule algebra,where the mapsαH,βH,ψH,ωH,αA,βA are bijective.We first prove the Maschke-type theorem for the BiHom-L-R smash product over a finite-dimensional semisimple BiHom-Hopf algebra.Next we give a Morita context between the BiHom-subalgebra A^(biH)and the BiHom-L-R smash product A#H.展开更多
DearEditor,The Arenaviridae family(recently assigned to the Bunyavirales order)is a group of emerging viruses that include causative agents of severe hemorrhagic fevers with high mortality in humans(de la Torre,2009)....DearEditor,The Arenaviridae family(recently assigned to the Bunyavirales order)is a group of emerging viruses that include causative agents of severe hemorrhagic fevers with high mortality in humans(de la Torre,2009).Lymphocytic choriomeningitis virus(LCMV)is the prototypic member of the Arenaviridae family and belongs to the Old World(OW)arenavirus together with Lassa virus(LASV),which are distinct from the New World(NW)arenavirus[e.g.Machupo virus(MACV)and Junin virus(JUNV)].LCMV infection in the fetus and newborm results in severe impairment of brain development associated with sensory loss and mental retardation and is also known to be associated with severe systemic infection with high mortality in transplantation patients(Palacios et al.,2008).展开更多
The core ecosystem functioning(e.g.trophic transfer efficiency)is at risk of being disrupted by the growing mismatch between nutrient content of primary producers and nutrient demand of grazing consumers.Ecological st...The core ecosystem functioning(e.g.trophic transfer efficiency)is at risk of being disrupted by the growing mismatch between nutrient content of primary producers and nutrient demand of grazing consumers.Ecological stoichiometry provides a conceptual framework that explains this trophic interaction using C,N and P elemental composition across trophic levels.In light of ongoing climate change and eutrophication,previous studies have raised concerns regarding the growing stoichiometric mismatch between phytoplankton and zooplankton,given the stoichiometric plasticity of phytoplankton.However,there is currently little conclusive evidence on the stoichiometric mismatch from a dual perspective of phytoplankton and zooplankton.To address this,we conducted a mesocosm experiment to investigate the separate and combined effects of climate warming(a constant increase of t3.5C plus heat waves)and eutrophication(nutrient addition)on stoichiometric mismatch between phytoplankton and zooplankton by examining stoichiometric changes in both communities.We observed a growing trend in stoichiometric mismatches when warming or nutrient addition acted individually,which was mediated by the increase in nutrient demand(N,P elements)of zooplankton growth.However,when these stressors acted jointly,the mismatches were reversed.This could be because climate warming and eutrophication combined would lead to changes in species composition,which accordingly reshaped the stoichiometric composition at the community level.These results illustrate the need of stoichiometric mismatches for understanding the implication of global change on trophic interactions and ecosystem functioning,requiring consideration not only of cross-trophic levels but also of compositional changes within communities.展开更多
Resorbable polymer electrospun nanofiber-based materials/devices have high surface-to-volume ratio and often have a porous structure with excellent pore interconnectivity,which are suitable for growth and development ...Resorbable polymer electrospun nanofiber-based materials/devices have high surface-to-volume ratio and often have a porous structure with excellent pore interconnectivity,which are suitable for growth and development of different types of cells.Due to the huge advantages of both resorbable polymers and electrospun nano fibers,re sorbable polymer electrospun nanofibers(RPENs)have been widely applied in the field of tissue engineering.In this paper,we will mainly introduce RPENs for tissue engineering.Firstly,the electrospinning technique and electrospun nanofiber architectures are briefly introduced.Secondly,the application of RPENs in the field of tissue engineering is mainly reviewed.Finally,the advantages and disadvantages of RPENs for tissue engineering are discussed.This review will provide a comprehensive guide to apply resorbable polymer electrospun nanofibers for tissue engineering.展开更多
Lithium-iodine(Li-I_(2))battery exhibits high potential to match with high-rate property and large energy density.However,problems of the system,such as evident sublimation of iodine elements,dissolution of iodine spe...Lithium-iodine(Li-I_(2))battery exhibits high potential to match with high-rate property and large energy density.However,problems of the system,such as evident sublimation of iodine elements,dissolution of iodine species in electrolyte,and lithium anode corrosion,prevent the practical use of rechargeable Li-I_(2)batteries.In this work,a molten Li-I_(2)typical cell design which has distinct advantages based on the solid-state garnet electrolyte with the eutectic iodate cathode is firstly developed.The U-shaped ceramic electrolyte tube can separate Li anode from the eutectic iodate cathode,so as to better tackle the above-mentioned inherent challenges for the liquid electrolyte systems.Without self-discharging and lithium anode corrosion,this solid-state battery system demonstrates high safety margin and excellent electrochemical performance.Also,the simple battery structure also indicates the easy assembly process and recycling of electrode materials.With the cathode loading of 593 mg in a single cell,an energy density of~506.7 Wh·kg^(-1)was achieved at 1 C and a long-term cycling life for 2,000 cycles also displays negligible capacity decay.展开更多
Safe and long lifespan batteries facilitate the development of portable electronics and electric vehicles.Owing to the low-cost,naturally abundance,and trivalent charge carrier of aluminum with the highest theoretical...Safe and long lifespan batteries facilitate the development of portable electronics and electric vehicles.Owing to the low-cost,naturally abundance,and trivalent charge carrier of aluminum with the highest theoretical volumetric capacity,rechargeable aqueous aluminum-ion-based batteries are considered as promising next-generation secondary batteries.However,traditional electrolytes and frequent collapse of the host structure of electrode materials greatly jeopardize the cycle stability of the batteries.Here,we develop a novel hydrogel-based electrolyte coupled with stable layered intercalation electrodes for the first time to fabricate a highly safe and flexible rechargeable hybrid Al^(3^(+))/H^(+)battery.The as-fabricated hybrid-ion battery(HIB)delivers a high specific capacity of 125 mAh·g^(−1) at 0.1 A·g^(−1) and exhibits an unprecedented super long-term cycling stability with no capacity fading over 10,000 cycles at 2 A·g^(−1).In addition,the hydrogel-based electrolyte possesses smart function of thermoresponsive switching,which can effectively prevent thermal runaway for the batteries.The unprecedented long cycle stability,highly intrinsic safety as well as low-cost indicate that the flexible aqueous HIBs are promising for applications.展开更多
Since the outbreak of coronavirus disease 2019(COVID-19),a large number of COVID-19-related reports have been published in journals or submitted to preprint platforms.In this study,we search the COVID-19-related liter...Since the outbreak of coronavirus disease 2019(COVID-19),a large number of COVID-19-related reports have been published in journals or submitted to preprint platforms.In this study,we search the COVID-19-related literature officially published and included in the Web of Science(WOS)database or submitted to four preprint platforms:bioRxiv,medRxiv,Preprints,and SSRN.Using data on the number of reports,author institution,country,and research category,we analyze global trends in COVID-19 research,including institution distribution and research hotspots.The results show that a large number of COVID-19-related reports have been produced;the United States has contributed the most published literature,followed by China.The United States has published the most reports included in the WOS in the categories of non-pharmaceutical interventions,treatment,and vaccine-related reports,while China has published the most literature in the categories of clinical features and complications,virology and immunology,epidemiology,and detection and diagnosis.Publication countries are concentrated in Asia,North America,and Europe,while South America and Africa have less literature.In conclusion,many scientific research issues related to COVID-19 need to be further clarified and COVID-19 research urgently needs global cooperation.展开更多
基金supported by research grants from the National Key R&D Program(2019YFD0902003)。
文摘Specific and sustained release of nutrients from capsules to the gastrointestinal tract has attracted many attentions in the field of food and drug delivery.In this work,we reported a monoaxial dispersion electrospraying-ionotropic gelation technique to prepare multicore millimeter-sized spherical capsules for specific and sustained release of fish oil.The spherical capsules had diameters from 2.05 mm to 0.35 mm with the increased applied voltages.The capsules consisted of uniform(at applied voltages of≤10 k V)or nonuniform(at applied voltages of>10 k V)multicores.The obtained capsules had reasonable loading ratios(9.7%-6.3%)due to the multicore structure.In addition,the obtained capsules had specific and sustained release behaviors of fish oil into the small intestinal phase of in vitro gastrointestinal tract and small intestinal tract models.The simple monoaxial dispersion electrospraying-ionotropic gelatin technique does not involve complicated preparation formulations and polymer modification,which makes the technique has a potential application prospect for the fish oil preparations and the encapsulation of functional active substances in the field of food and drug industries.
基金the financial support of Post-doctoral Start-up funding (2018) of Northwest A&F University (Z109021804)National Natural Science Foundation of China (31972043 and 32001652)。
文摘Colorectal cancer(CRC)is one of the most common cancers and supplementation of probiotics may be a promising intervention method. The present study aimed to investigate the anti-CRC effects of Lactiplantibacillus plantarum KX041 on a CRC mouse model. The CRC mice were induced by 10 mg/kg azoxymethane and 2% dextran sulfate sodium. L. plantarum KX041 was orally administrated once daily(1 × 10^(9) CFU/mouse). Results showed that L. plantarum KX041 could significantly inhibit inflammation, tumor formation, and induce tumor cells apoptosis. Moreover, this probiotic could ameliorate the damage of intestinal barrier by recovering tight junction protein expression(like Occludin, Claudin-1, and ZO-1)and preventing goblet cell loss. Furthermore, the oxidative stress was alleviated by increasing the level of antioxidant mediators(like GSH and SOD)and reducing the level of oxidative mediators(like MDA and MPO). In addition, treatment with L. plantarum KX041 could directly regulate gut microbiota, thereby increasing the abundance of beneficial bacteria(like SCFAs-producing bacteria, Akkermansia)and decreasing the abundance of harmful bacteria(like pro-inflammatory bacteria, Parasutterella), which in turn raised SCFAs levels and lowered LPS levels. In conclusion, L. plantarum KX041 could effectively ameliorate CRC via reshaping intestinal microenvironment, alleviating inflammation, maintaining intestinal permeability, and attenuating oxidative stress.
基金supported by the National Key R&D Program “Precision Medicine” of China (Grant No. 2016YFC0901403)the Major Science and Technology Projects of Henan Province (Grant No. 16110031 1300)+2 种基金the Doctoral Team Foundation of the First Affiliated Hospital of Zhengzhou University (Grant No. 2016-BSTDJJ-03)the National Natural Science Foundation of China (Grant No. 81872032, U1804262)the State Key Laboratory of Esophageal Cancer Prevention and Treatment (Grant No. Z2020-0010)。
文摘Objective: There are no comprehensive studies on survival outcomes and optimal treatment protocols for cervical esophageal cancer(CEC), due to its rare clinical prevalence. Our objective was to determine the relationship between pathological characteristics, treatment protocols, and survival outcomes in Chinese CEC patients.Methods: A total of 500 Chinese CEC patients were selected from our 500,000 esophageal and gastric cardia carcinoma database(1973–2018). There were two main groups: patients treated with surgery, and patients receiving non-surgical treatments(radiotherapy, radiochemotherapy, and chemotherapy). The Chi-square test and Kaplan–Meier method were used to compare the continuous variables and survival.Results: Among the 500 CEC patients, 278(55.6%) were male, and the median age was 60.9 ± 9.4 years. A total of 496 patients(99.2%) were diagnosed with squamous cell carcinoma. In 171(34.2%) patients who received surgery, 22(12.9%) had undergone laryngectomy. In 322(64.4%) patients who received non-surgical treatments, 245(76.1%) received radiotherapy. Stratified survival analysis showed that only T stage was related with survival outcomes for CEC patients in the surgical group, and the outcomes between laryngectomy and non-laryngectomy patients were similar. It was noteworthy that the 5-year survival rate was similar in CEC patients among the different groups treated with surgery, radiotherapy, chemotherapy, or radiochemotherapy(P = 0.244). Conclusions: The CEC patients had similar survival outcomes after curative esophagectomy and radiotherapy, including those with or without total laryngectomy. These findings suggest that radiotherapy could be the initial choice for treatment of Chinese CEC patients.
基金Supported by Fundamental Research Funds for the Central Universities(Grant No.2017XKQY032)
文摘A precise detection of the fault feature parameter of motor current is a new research hotspot in the broken rotor bar(BRB) fault diagnosis of induction motors. Discrete Fourier transform(DFT) is the most popular technique in this field, owing to low computation and easy realization. However, its accuracy is often limited by the data window length, spectral leakage, fence e ect, etc. Therefore, a new detection method based on a global optimization algorithm is proposed. First, a BRB fault current model and a residual error function are designed to transform the fault parameter detection problem into a nonlinear least-square problem. Because this optimization problem has a great number of local optima and needs to be resolved rapidly and accurately, a joint algorithm(called TR-MBPSO) based on a modified bare-bones particle swarm optimization(BPSO) and trust region(TR) is subsequently proposed. In the TR-MBPSO, a reinitialization strategy of inactive particle is introduced to the BPSO to enhance the swarm diversity and global search ability. Meanwhile, the TR is combined with the modified BPSO to improve convergence speed and accuracy. It also includes a global convergence analysis, whose result proves that the TR-MBPSO can converge to the global optimum with the probability of 1. Both simulations and experiments are conducted, and the results indicate that the proposed detection method not only has high accuracy of parameter estimation with short-time data window, e.g., the magnitude and frequency precision of the fault-related components reaches 10^(-4), but also overcomes the impacts of spectral leakage and non-integer-period sampling. The proposed research provides a new BRB detection method, which has enough precision to extract the parameters of the fault feature components.
基金supported by the National Key Research and Development (R&D) Program of China (2019YFD1100104-03-01)the National Natural Science Foundation of China (52000048)+1 种基金the Cooperative Researching Project of Chunhui Program,Ministry of Education,China (HLJ2019006)Heilongjiang Key Laboratory of Ozone Application Technology and Equipment Development(OZO202104)
文摘1.The object-to-human transmission route of SARS-CoV-2 At the time of writing,coronavirus disease 2019(COVID-19),which is caused by the severe acute respiratory syndrome coron-avirus 2(SARS-CoV-2),has been a global pandemic for more than a year.As of 22 September 2021,the global cumulative incidence exceeds 229 million cases,and the number of deaths has exceeded 4.75 million[1].The current situation of epidemic prevention and control within the countries around the world can be roughly divided into two stages:the pandemic stage that the United States,the United Kingdom,and India are still experiencing(as of 23 September 2021,newly reported cases in the last 24 h in the United States,United Kingdom,and India are 202840,31095,and 26964,respectively[1]);and the normalized epidemic pre-vention and control stage that countries such as China and New Zealand are currently in.
基金This work is financially supported by the Fundamental Research Funds for the Central Universities,China(Nos.2302017FRF-IC-17-001,2302018FRF-IC-18-004,232019 FRF-IC-19-018,and 2302020FRF-IC-20-10)the China Postdoctoral Science Foundation(No.2021M700378).
文摘The limited wide applicability of commercial Mg alloys is mainly attributed to the poor corrosion resistance.Addition of alloying elements is the simplest and effective method to improve the corrosion properties.Based on the low-cost alloy composition design,the corro-sion behavior of commercial Mg-3Al-1Zn(AZ31)alloy bearing minor Ca or Sn element was characterized by scanning Kelvin probe force microscopy,hydrogen evolution,electrochemical measurements,and corrosion morphology analysis.Results revealed that the potential differ-ence of Al_(2)Ca/α-Mg and Mg_(2)Sn/α-Mg was(230±19)mV and(80±6)mV,respectively,much lower than that of Al_(8)Mn_(5)/α-Mg(430±31)mV in AZ31 alloy,which illustrated that AZ31-0.2Sn alloy performed the best corrosion resistance,followed by AZ31-0.2Ca,while AZ31 al-loy exhibited the worst corrosion resistance.Moreover,Sn dissolved into matrix obviously increased the potential ofα-Mg and participated in the formation of dense SnO_(2) film at the interface of matrix,while Ca element was enriched in the corrosion product layer,resulting in the cor-rosion product layer of AZ31-0.2Ca/Sn alloys more compact,stable,and protective than AZ31 alloy.Therefore,AZ31 alloy bearing 0.2wt%Ca or Sn element exhibited excellent balanced properties,which is potential to be applied in commercial more comprehensively.
基金the National Natural Science Foundation of China(No.21805063)the Natural Science Foundation of Guangdong Province for Distinguished Young Scholars(No.2018B030306022)+1 种基金the Economic,Trade and Information Commission of Shenzhen Municipality through the Graphene Manufacture Innovation Center(No.201901161514)The authors also acknowledge the support from China Postdoctoral Science Foundation(2018M641823).
文摘Flexible rechargeable aqueous zinc-ion batteries(ZIBs)have attracted extensive attentions in the energy storage field due to their high safety,environmental friendliness,and outstanding electrochemical performance while the exploration of high-voltage aqueous ZIBs with excellent rate capability is still a great challenge for the further application them in flexible and wearable electronics.Herein,we fabricated a 2.4 V high-voltage flexible aqueous ZIB,being among the highest voltage reported in aqueous ZIBs.Moreover,it exhibits extremely flat charging/discharging voltage platforms and the dropout voltage is only 0.1 V,which is the smallest gap in all aqueous batteries to our best knowledge.Furthermore,the prepared ZIB performs high rate capability of 25 C and energy density of 120 Wh kg?1 and exhibits excellent safety under various destructive conditions including hammering,sewing,punching,and soaking.These extraordinary results indicate the great application potential of our high-voltage flexible aqueous ZIB in wearable electronics.
基金supported by the National Natural Science Foundation of China(No.91964101)the Fund of State Key Laboratory of Information Photonics and Optical Communications(Beijing University of Posts and Telecommunications)and the Research Innovation Fund for College Students of Beijing University of Posts and Telecommunications.
文摘Owing to the high carrier mobility,two-dimensional(2D)gallium antimonite(GaSb)is a promising channel material for field-effect transistors(FETs)in the post-silicon era.We investigated the ballistic performance of the 2D GaSb metal-oxide-semiconductor FETs with a 10 nm-gate-length by the ab initio quantum transport simulation.Because of the wider bandgap and better gate-control ability,the performance of the 10-nm monolayer(ML)GaSb FETs is generally superior to the bilayer counterparts,including the three-to-four orders of magnitude larger on-current.Via hydrogenation,the delaytime and power consumption can be further enhanced with magnitude up to 35%and 57%,respectively,thanks to the expanded bandgap.The 10-nm ML GaSb FETs can almost meet the International Technology Roadmap for Semiconductors(ITRS)for high-performance demands in terms of the on-state current,intrinsic delay time,and power-delay product.
基金This work was supported by National Natural Science Foundation of China(NSFC)(81500871)Natural Science Foundation of Guangdong Province(2016A030310214).
文摘Periodontal disease is the leading cause of tooth loss,which is also a high-risk factor for other diseases including oral cancer and cardiovascular disease.Periodontitis is one of the most common type of periodontal diseases.Interleukin-1β(IL-1β)plays a key role in the pathogenesis of periodontitis.However,the mechanism how IL-1βis produced during periodontitis is still unclear.In the present study,we found that humanβ-defensin 2(hBD2)enhances IL-1βproduction through an LPS-primed human acute monocytic leukemia(THP-1)macrophage model.Inhibition of P2X purinoceptor 7(P2X7)reduced hBD2-enhanced IL-1βproduction.Incubation of LPS-primed THP-1 macrophages with potassium chloride also suppressed hBD2-enhanced IL-1βproduction.Silence of inflammasome adaptor Nod-like receptor family pyrin domain containing 3(NLRP3)led to reduced hBD2-enhanced IL-1βproduction.Likewise,inhibition of caspase-1 also resulted in the decrease of IL-1β.Moreover,an ethidium bromide uptake test indicated that hBD2-activated caspase-1 mediated pyroptotic pore formation.Subsequent lactate dehydrogenase detection and flow cytometric analysis indicated that hBD2 also induced pyroptosis.In brief,these findings illustrated not only the mechanism of hBD2 in enhancing the inflammatory response,but also provided novel therapeutic targets for periodontitis.
基金Supported by Doctoral Scientific Research Start-up Project of Mudanjiang Normal University(MSB200912)Provincial Key Pre-research Project of Mudanjiang Normal University(SY2014010)Teaching Reform Project of Mudanjiang Normal University(2013JGZX0074)
文摘In this study, four phosphorus-inefficient soybean genotypes （1903, 1305, D17 and D18） and four phosphorus-efficient soybean genotypes （D31, D34, D37 and D38 ） were selected as experimental materials for soil culture experiment under high and low phosphorus treatments, to investigate the grain yield, phosphorus content, phosphorus uptake and the relationship between phosphorus utilization efficiency and phosphorus efficiency of soybean genotypes with different phos- phorus efficiency in mature period. According to the experimental results, under low phosphorus treatment, four phosphorus-efficient soybean genotypes exhibited significantly high phosphorus uptake in mature period, especially for D31 and D37; however, three phosphorus-efficient genotypes showed no advantages in adapta- bility of phosphorus utilization efficiency, while only I）31 exhibited high phosphorus utilization and absorption capacity. Correlation analysis and path analysis showed that phosphorus deficiency of soybean was mainly detemained by phosphorus absorption capacity, and phosphorus deficiency under （-P） treatment was sig- nificandy higher than （ ＋ P） treatment. Phosphorus uptake and phosphorus utilization efficiency posed great direct effects on phosphorus efficiency, and phosphorus uptake exhibited a greater contribution ; in addition, these two factors both posed small indirect effects. In mature period at reproductive growth stage, phosphorus absorption efficiency （phosphorus uptake） was the main variation source of phosphorus efficiency of various soybean genotypes in mature period. Therefore, strong phosphorus uptake and accumulation capacity of phosphorus-efficient soybean genotypes in mature period is an important nutrition foundation for the information of high grain yield.
基金This research was supported by funding from the National Natural Science Foundation of China(No.82022078).
文摘The insulin-like growth factor(IGF)axis plays important roles in cancer development and metastasis.The type 1 IGF receptor(IGF-1R)is a key member in the IGF axis and has long been recognized for its oncogenic role in multiple cancer lineages.Here we review the occurrence of IGF-1R aberrations and activation mechanisms in cancers,which justify the development of anti-IGF-1R therapies.We describe the therapeutic agents available for IGF-1R inhibition,with focuses on the recent or ongoing pre-clinical and clinical studies.These include antisense oligonucleotide,tyrosine kinase inhibitors and monoclonal antibodies which may be conjugated with cytotoxic drug.Remarkably,simultaneous targeting of IGF-1R and several other oncogenic vulnerabilities has shown early promise,highlighting the potential benefits of combination therapy.Further,we discuss the challenges in targeting IGF-1R so far and new concepts to improve therapeutic efficacy such as blockage of the nuclear translocationofIGF-1R.
基金supported by the NSF of China(Nos.11801515,12071441)the Natural Science Foundation of Zhejiang Province(No.LY20A010003)the Foundation of Zhejiang Educational Committee(No.Y201942625).
文摘Let(H,αH,βH,ψH,ωH,SH)be a BiHom-Hopf algebra and(A,αA,βA)be an(H,αH,βH,ψH,ωH)-BiHom-bimodule algebra,where the mapsαH,βH,ψH,ωH,αA,βA are bijective.We first prove the Maschke-type theorem for the BiHom-L-R smash product over a finite-dimensional semisimple BiHom-Hopf algebra.Next we give a Morita context between the BiHom-subalgebra A^(biH)and the BiHom-L-R smash product A#H.
基金facility support.This work was supported by the National Natural Science Foundation of China(32188101 and U20A20135)the National Program on Key Research Project of China(2020YFA0707500),and Tsinghua University Spring Breeze Fund.
文摘DearEditor,The Arenaviridae family(recently assigned to the Bunyavirales order)is a group of emerging viruses that include causative agents of severe hemorrhagic fevers with high mortality in humans(de la Torre,2009).Lymphocytic choriomeningitis virus(LCMV)is the prototypic member of the Arenaviridae family and belongs to the Old World(OW)arenavirus together with Lassa virus(LASV),which are distinct from the New World(NW)arenavirus[e.g.Machupo virus(MACV)and Junin virus(JUNV)].LCMV infection in the fetus and newborm results in severe impairment of brain development associated with sensory loss and mental retardation and is also known to be associated with severe systemic infection with high mortality in transplantation patients(Palacios et al.,2008).
基金supported by the National Natural Science Foundation of China[grant numbers 32171515,31800389]the Hundred-Talent Program of the Chinese Academy of Sciencesthe International Cooperation Project of the Chinese Academy of Sciences[grant numbers 152342KYSB20190025].
文摘The core ecosystem functioning(e.g.trophic transfer efficiency)is at risk of being disrupted by the growing mismatch between nutrient content of primary producers and nutrient demand of grazing consumers.Ecological stoichiometry provides a conceptual framework that explains this trophic interaction using C,N and P elemental composition across trophic levels.In light of ongoing climate change and eutrophication,previous studies have raised concerns regarding the growing stoichiometric mismatch between phytoplankton and zooplankton,given the stoichiometric plasticity of phytoplankton.However,there is currently little conclusive evidence on the stoichiometric mismatch from a dual perspective of phytoplankton and zooplankton.To address this,we conducted a mesocosm experiment to investigate the separate and combined effects of climate warming(a constant increase of t3.5C plus heat waves)and eutrophication(nutrient addition)on stoichiometric mismatch between phytoplankton and zooplankton by examining stoichiometric changes in both communities.We observed a growing trend in stoichiometric mismatches when warming or nutrient addition acted individually,which was mediated by the increase in nutrient demand(N,P elements)of zooplankton growth.However,when these stressors acted jointly,the mismatches were reversed.This could be because climate warming and eutrophication combined would lead to changes in species composition,which accordingly reshaped the stoichiometric composition at the community level.These results illustrate the need of stoichiometric mismatches for understanding the implication of global change on trophic interactions and ecosystem functioning,requiring consideration not only of cross-trophic levels but also of compositional changes within communities.
基金supported by research grants from the National Key R&D Program of China(No.2016YFD0400202-8)Scientific Instruments Development Project of the Science and Technology Commission of Shanghai Municipality(No.17142202800)。
文摘Resorbable polymer electrospun nanofiber-based materials/devices have high surface-to-volume ratio and often have a porous structure with excellent pore interconnectivity,which are suitable for growth and development of different types of cells.Due to the huge advantages of both resorbable polymers and electrospun nano fibers,re sorbable polymer electrospun nanofibers(RPENs)have been widely applied in the field of tissue engineering.In this paper,we will mainly introduce RPENs for tissue engineering.Firstly,the electrospinning technique and electrospun nanofiber architectures are briefly introduced.Secondly,the application of RPENs in the field of tissue engineering is mainly reviewed.Finally,the advantages and disadvantages of RPENs for tissue engineering are discussed.This review will provide a comprehensive guide to apply resorbable polymer electrospun nanofibers for tissue engineering.
文摘Lithium-iodine(Li-I_(2))battery exhibits high potential to match with high-rate property and large energy density.However,problems of the system,such as evident sublimation of iodine elements,dissolution of iodine species in electrolyte,and lithium anode corrosion,prevent the practical use of rechargeable Li-I_(2)batteries.In this work,a molten Li-I_(2)typical cell design which has distinct advantages based on the solid-state garnet electrolyte with the eutectic iodate cathode is firstly developed.The U-shaped ceramic electrolyte tube can separate Li anode from the eutectic iodate cathode,so as to better tackle the above-mentioned inherent challenges for the liquid electrolyte systems.Without self-discharging and lithium anode corrosion,this solid-state battery system demonstrates high safety margin and excellent electrochemical performance.Also,the simple battery structure also indicates the easy assembly process and recycling of electrode materials.With the cathode loading of 593 mg in a single cell,an energy density of~506.7 Wh·kg^(-1)was achieved at 1 C and a long-term cycling life for 2,000 cycles also displays negligible capacity decay.
基金This research was supported by the National Natural Science Foundation of China (No. 21805063)the Natural Science Foundation of Guangdong Province for Distinguished Young Scholars (No. 2018B030306022)+1 种基金the Economic, Trade and Information Commission of Shenzhen Municipality through the Graphene Manufacture Innovation Center (No. 201901161514)and Research Innovation Fund of Harbin Institute of Technology (No. HIT.NSRIF.2020063).
文摘Safe and long lifespan batteries facilitate the development of portable electronics and electric vehicles.Owing to the low-cost,naturally abundance,and trivalent charge carrier of aluminum with the highest theoretical volumetric capacity,rechargeable aqueous aluminum-ion-based batteries are considered as promising next-generation secondary batteries.However,traditional electrolytes and frequent collapse of the host structure of electrode materials greatly jeopardize the cycle stability of the batteries.Here,we develop a novel hydrogel-based electrolyte coupled with stable layered intercalation electrodes for the first time to fabricate a highly safe and flexible rechargeable hybrid Al^(3^(+))/H^(+)battery.The as-fabricated hybrid-ion battery(HIB)delivers a high specific capacity of 125 mAh·g^(−1) at 0.1 A·g^(−1) and exhibits an unprecedented super long-term cycling stability with no capacity fading over 10,000 cycles at 2 A·g^(−1).In addition,the hydrogel-based electrolyte possesses smart function of thermoresponsive switching,which can effectively prevent thermal runaway for the batteries.The unprecedented long cycle stability,highly intrinsic safety as well as low-cost indicate that the flexible aqueous HIBs are promising for applications.
文摘Since the outbreak of coronavirus disease 2019(COVID-19),a large number of COVID-19-related reports have been published in journals or submitted to preprint platforms.In this study,we search the COVID-19-related literature officially published and included in the Web of Science(WOS)database or submitted to four preprint platforms:bioRxiv,medRxiv,Preprints,and SSRN.Using data on the number of reports,author institution,country,and research category,we analyze global trends in COVID-19 research,including institution distribution and research hotspots.The results show that a large number of COVID-19-related reports have been produced;the United States has contributed the most published literature,followed by China.The United States has published the most reports included in the WOS in the categories of non-pharmaceutical interventions,treatment,and vaccine-related reports,while China has published the most literature in the categories of clinical features and complications,virology and immunology,epidemiology,and detection and diagnosis.Publication countries are concentrated in Asia,North America,and Europe,while South America and Africa have less literature.In conclusion,many scientific research issues related to COVID-19 need to be further clarified and COVID-19 research urgently needs global cooperation.
